NCT02922296Active, not recruiting
Glucose Metabolism in Sickle Cell Disease
Source: ClinicalTrials.gov · Last updated 21 Sept 2026
Brief summary (registry, in English)
The purpose of the study is to better understand how the body handles sugars glucose and fats, such as cholesterol and triglycerides in sickle cell disease, and what puts certain persons at risk to develop diabetes. This understanding may help us to find new treatments to control blood sugar and prevent diabetes in people with and without sickle cell disease (SCD). In this research, DNA and RNA will be isolated from blood cells. DNA will be used to find genes that cause or protect from diabetes, high cholesterol and high triglyceride, and RNA will be used for studies designed to find out how genes are doing their job of eventually producing proteins.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 75 (estimated)
- First submitted
- 31 Jul 2016
- Start date
- 1 May 2015
- Primary completion date
- 1 Aug 2028
- Lead sponsor
- University of Illinois Chicago
- Diseases
- Sickle cell disease
- NCT number
- NCT02922296
What you commit to
- Study type: Observational
- Planned participants: 75
- From 1 May 2015 to the primary completion date, 1 Aug 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients receiving insulin therapy
Other illness
- Acute inflammatory or infectious illness or injury
Who the study is looking for
- Major sickling genotype (hemoglobin SS, Sbeta0-thalassemia, SOarab, SDpunjab)
- Age \>35 years
- BMI \<25 kg/m2 or \>26 kg/m2
- Steady state, defined as \>two weeks from a hospitalization for vaso-occlusive crisis, infection or surgery and not requiring immediate parenteral medication for pain control
- Fasting state (\>8 hours since ingesting food or medication for diabetes)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Illinois at Chicago Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.