NCT02923570Active, not recruitingPhase 2
Study of Proton Versus Photon Beam Radiotherapy in the Treatment of Head and Neck Cancer
A Phase II Randomized Study of Proton Versus Photon Beam Radiotherapy in the Treatment of Unilateral Head and Neck Cancer
Source: ClinicalTrials.gov · Last updated 5 Nov 2025
Brief summary (registry, in English)
Compared to IMRT, PBRT is thought to give less radiation exposure to the surrounding healthy tissues. It is possible that side effect rates with PBRT will be lower or the same compared to IMRT, but this has not been well studied to date. Although both of these radiation therapies have been used in the past to treat head and neck cancer, this research study will compare the effects of these two different radiation treatment modalities with each other to see whether PBRT is better, the same or worse than IMRT.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 108 (actual)
- First submitted
- 3 Oct 2016
- Start date
- 3 Oct 2016
- Primary completion date
- Oct 2026
- Lead sponsor
- Memorial Sloan Kettering Cancer Center
- Diseases
- Head and neck cancer
- NCT number
- NCT02923570
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 108
- From 3 Oct 2016 to the primary completion date, Oct 2026
- 9 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Any prior head or neck irradiation.
- Physician recommendation of bilateral neck radiation.
- Physician recommendation of mucosal radiation
Other illness
- Non-resectable disease
Who the study is looking for
- Age greater than or equal to 18.
- Histopathologically confirmed diagnosis of one the following cancer types:
- Salivary gland cancer
- Skin cancer
- Melanoma
- HNSCC that require ipsilateral radiation
- Patients must be a candidate for ipsilateral radiation therapy.
- Karnofsky performance status ≥70.
- Negative pregnancy test for women of childbearing potential (\<51 years of age) as per institutional policy.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (9)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Memorial Sloan Kettering Basking Ridge Coordinator of this site? Confirm its status | Basking Ridge | United States | Unknown status |
| Memorial Sloan Kettering Commack Coordinator of this site? Confirm its status | Commack | United States | Unknown status |
| Memorial Sloan Kettering Westchester Coordinator of this site? Confirm its status | Harrison | United States | Unknown status |
| Baptist Alliance - McI Coordinator of this site? Confirm its status | Miami | United States | Unknown status |
| Memorial Sloan Kettering Monmouth Coordinator of this site? Confirm its status | Middletown | United States | Unknown status |
| Memorial Sloan Kettering Bergen Coordinator of this site? Confirm its status | Montvale | United States | Unknown status |
| Memorial Sloan-Kettering Cancer Center Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Mayo Clinic Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
| Memorial Sloan Kettering Nassau Coordinator of this site? Confirm its status | Uniondale | United States | Unknown status |
Related publications
- A phase II randomized study of proton therapy vs intensity-modulated radiation therapy in patients with unilateral head and neck cancer.J Natl Cancer Inst · 2026 · PMID 42690689
This page is information, not medical advice. Discuss any trial with your doctor.