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NCT02927769CompletedPhase 2

A Study of Nivolumab Plus Brentuximab Vedotin in Patients Between 5 and 30 Years Old, With Hodgkin's Lymphoma (cHL), Relapsed or Refractory From First Line Treatment

Risk-based, Response-adapted, Phase II Open-label Trial of Nivolumab + Brentuximab Vedotin (N + Bv) for Children, Adolescents, and Young Adults With Relapsed/Refractory (R/R) CD30 + Classic Hodgkin Lymphoma (cHL) After Failure of First-line Therapy, Followed by Brentuximab + Bendamustine (Bv + B) for Participants With a Suboptimal Response (CheckMate 744: CHECKpoint Pathway and Nivolumab Clinical Trial Evaluation)

Source: ClinicalTrials.gov · Last updated 10 Feb 2025

Brief summary (registry, in English)

The purpose of this study is to determine whether nivolumab plus brentuximab vedotin (followed by brentuximab vedotin plus bendamustine in patient with suboptimal response) is safe and effective in treating patients with Hodgkin's lymphoma (cHL). Eligible patients are children, adolescents, and young adults relapsed or refractory to first line.

Status (registry)
Completed
Phase (registry)
Phase 2
Study type
Interventional
Enrollment
72 (actual)
First submitted
6 Oct 2016
Start date
28 Mar 2017
Primary completion date
28 May 2024
Lead sponsor
Bristol-Myers Squibb
NCT number
NCT02927769
EudraCT number
2016-002347-41

What you commit to

  • Study type: Interventional · Phase 2
  • Participants enrolled: 72
  • From 28 Mar 2017 to the primary completion date, 28 May 2024
  • 79 sites in 11 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Received a stem cell transplant for Hodgkin Lymphoma and/or a solid organ transplant
  • Prior treatment with any drug that targets T cell co-stimulation pathways (such as checkpoint inhibitors)
    • Other protocol defined inclusion/exclusion criteria apply

Other illness

  • Active, known, or suspected autoimmune disease or infection
  • Active cerebral/meningeal disease related to the underlying malignancy
  • More than one line of anti-cancer therapy or no treatment at all

Who the study is looking for

  • Classic Hodgkin Lymphoma (cHL), relapsed or refractory
  • Minimal limitation on activities of daily living as measured by Karnofsky ≥ 50 for participants \> 16 years of age or Lansky ≥ 50 for participants ≤ 16 years of age.
  • One prior anti-cancer therapy that did not work

Age in the registry: 5 years to 30 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (79)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
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CalgaryCanadaUnknown status
The Montreal Children's Hospital of the MUHC
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MontrealCanadaUnknown status
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TorontoCanadaUnknown status
Klinika detske hematologie a onkologie
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PragueCzechiaUnknown status
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BerlinGermanyUnknown status
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GiessenGermanyUnknown status
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HanoverGermanyUnknown status
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MünchenGermanyUnknown status
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BarcelonaSpainUnknown status
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MadridSpainUnknown status
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LilleFranceUnknown status
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LyonFranceUnknown status
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MarseilleFranceUnknown status
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NantesFranceUnknown status
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ParisFranceUnknown status
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ParisFranceUnknown status
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ToulouseFranceUnknown status
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Vandœuvre-lès-NancyFranceUnknown status
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VillejuifFranceUnknown status
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BirminghamUnited KingdomUnknown status
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GlasgowUnited KingdomUnknown status
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LeedsUnited KingdomUnknown status
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LeedsUnited KingdomUnknown status
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LondonUnited KingdomUnknown status
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ManchesterUnited KingdomUnknown status
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DublinIrelandUnknown status
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Aviano (PN)ItalyUnknown status
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BolognaItalyUnknown status
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GenovaItalyUnknown status
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Monza (mb)ItalyUnknown status
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NaplesItalyUnknown status
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RomaItalyUnknown status
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RotterdamNetherlandsUnknown status
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UtrechtNetherlandsUnknown status
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GdanskPolandUnknown status
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KrakowPolandUnknown status
Children's Healthcare of Atlanta
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AtlantaUnited StatesUnknown status
Childrens Hospital of Colorado
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AuroraUnited StatesUnknown status
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AustinUnited StatesUnknown status
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BaltimoreUnited StatesUnknown status
Children's Hospital of Alabama
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BirminghamUnited StatesUnknown status
Dana-Farber Cancer Institute
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BostonUnited StatesUnknown status
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BuffaloUnited StatesUnknown status
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Chapel HillUnited StatesUnknown status
Carolinas Medical Center
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CharlotteUnited StatesUnknown status
Cincinnati Children's Hospital Medical Center
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CincinnatiUnited StatesUnknown status
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ColumbusUnited StatesUnknown status
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DallasUnited StatesUnknown status
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DetroitUnited StatesUnknown status
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HackensackUnited StatesUnknown status
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HersheyUnited StatesUnknown status
Baylor College of Medicine
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HoustonUnited StatesUnknown status
University of Iowa
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Iowa CityUnited StatesUnknown status
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JacksonUnited StatesUnknown status
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JacksonvilleUnited StatesUnknown status
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Kansas CityUnited StatesUnknown status
Nevada Cancer Research Foundation
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Las VegasUnited StatesUnknown status
Loma Linda University Cancer Center
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Loma LindaUnited StatesUnknown status
Valley Children's Hospital
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MaderaUnited StatesUnknown status
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MilwaukeeUnited StatesUnknown status
Vanderbilt University
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NashvilleUnited StatesUnknown status
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New BrunswickUnited StatesUnknown status
Smilow Cancer Hospital At Yale New Haven Hospital
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New HavenUnited StatesUnknown status
Children'S Hosp-Kings Daughter
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NorfolkUnited StatesUnknown status
Children'S Hospital & Research Center At Oakland
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OaklandUnited StatesUnknown status
University of Oklahoma Health Sciences Center
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Oklahoma CityUnited StatesUnknown status
Children's Hospital of Orange County
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OrangeUnited StatesUnknown status
Lucile Packard Children'S Research Hospital/Stanford Univ
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Palo AltoUnited StatesUnknown status
Childrens Hospital of Philadelphia
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PhiladelphiaUnited StatesUnknown status
Phoenix Children s Hospital
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PhoenixUnited StatesUnknown status
Childrens Hospital Of Pittsburgh Of Upmc
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PittsburghUnited StatesUnknown status
Virginia Commonwealth University
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RichmondUnited StatesUnknown status
Primary Children's Hospital
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Salt Lake CityUnited StatesUnknown status
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San DiegoUnited StatesUnknown status
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SeattleUnited StatesUnknown status
Washington University School of Medicine
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St LouisUnited StatesUnknown status
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St. PetersburgUnited StatesUnknown status
Children's National Medical Center
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Washington D.C.United StatesUnknown status
Nemours A. I. duPont Hospital for Children
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WilmingtonUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.