NCT02927769CompletedPhase 2
A Study of Nivolumab Plus Brentuximab Vedotin in Patients Between 5 and 30 Years Old, With Hodgkin's Lymphoma (cHL), Relapsed or Refractory From First Line Treatment
Risk-based, Response-adapted, Phase II Open-label Trial of Nivolumab + Brentuximab Vedotin (N + Bv) for Children, Adolescents, and Young Adults With Relapsed/Refractory (R/R) CD30 + Classic Hodgkin Lymphoma (cHL) After Failure of First-line Therapy, Followed by Brentuximab + Bendamustine (Bv + B) for Participants With a Suboptimal Response (CheckMate 744: CHECKpoint Pathway and Nivolumab Clinical Trial Evaluation)
Source: ClinicalTrials.gov · Last updated 10 Feb 2025
Brief summary (registry, in English)
The purpose of this study is to determine whether nivolumab plus brentuximab vedotin (followed by brentuximab vedotin plus bendamustine in patient with suboptimal response) is safe and effective in treating patients with Hodgkin's lymphoma (cHL). Eligible patients are children, adolescents, and young adults relapsed or refractory to first line.
- Status (registry)
- Completed
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 72 (actual)
- First submitted
- 6 Oct 2016
- Start date
- 28 Mar 2017
- Primary completion date
- 28 May 2024
- Lead sponsor
- Bristol-Myers Squibb
- Diseases
- Hodgkin lymphoma, Childhood cancers
- NCT number
- NCT02927769
- EudraCT number
- 2016-002347-41
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 72
- From 28 Mar 2017 to the primary completion date, 28 May 2024
- 79 sites in 11 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Received a stem cell transplant for Hodgkin Lymphoma and/or a solid organ transplant
- Prior treatment with any drug that targets T cell co-stimulation pathways (such as checkpoint inhibitors)
- Other protocol defined inclusion/exclusion criteria apply
Other illness
- Active, known, or suspected autoimmune disease or infection
- Active cerebral/meningeal disease related to the underlying malignancy
- More than one line of anti-cancer therapy or no treatment at all
Who the study is looking for
- Classic Hodgkin Lymphoma (cHL), relapsed or refractory
- Minimal limitation on activities of daily living as measured by Karnofsky ≥ 50 for participants \> 16 years of age or Lansky ≥ 50 for participants ≤ 16 years of age.
- One prior anti-cancer therapy that did not work
Age in the registry: 5 years to 30 years · Sex: All · Does not accept healthy volunteers
Sites (79)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| - Coordinator of this site? Confirm its status | Calgary | Canada | Unknown status |
| The Montreal Children's Hospital of the MUHC Coordinator of this site? Confirm its status | Montreal | Canada | Unknown status |
| - Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| Klinika detske hematologie a onkologie Coordinator of this site? Confirm its status | Prague | Czechia | Unknown status |
| - Coordinator of this site? Confirm its status | Berlin | Germany | Unknown status |
| - Coordinator of this site? Confirm its status | Giessen | Germany | Unknown status |
| - Coordinator of this site? Confirm its status | Hanover | Germany | Unknown status |
| - Coordinator of this site? Confirm its status | München | Germany | Unknown status |
| - Coordinator of this site? Confirm its status | Barcelona | Spain | Unknown status |
| - Coordinator of this site? Confirm its status | Madrid | Spain | Unknown status |
| - Coordinator of this site? Confirm its status | Lille | France | Unknown status |
| - Coordinator of this site? Confirm its status | Lyon | France | Unknown status |
| - Coordinator of this site? Confirm its status | Marseille | France | Unknown status |
| - Coordinator of this site? Confirm its status | Nantes | France | Unknown status |
| - Coordinator of this site? Confirm its status | Paris | France | Unknown status |
| - Coordinator of this site? Confirm its status | Paris | France | Unknown status |
| - Coordinator of this site? Confirm its status | Toulouse | France | Unknown status |
| - Coordinator of this site? Confirm its status | Vandœuvre-lès-Nancy | France | Unknown status |
| - Coordinator of this site? Confirm its status | Villejuif | France | Unknown status |
| - Coordinator of this site? Confirm its status | Birmingham | United Kingdom | Unknown status |
| - Coordinator of this site? Confirm its status | Glasgow | United Kingdom | Unknown status |
| - Coordinator of this site? Confirm its status | Leeds | United Kingdom | Unknown status |
| - Coordinator of this site? Confirm its status | Leeds | United Kingdom | Unknown status |
| - Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| - Coordinator of this site? Confirm its status | Manchester | United Kingdom | Unknown status |
| - Coordinator of this site? Confirm its status | Dublin | Ireland | Unknown status |
| - Coordinator of this site? Confirm its status | Aviano (PN) | Italy | Unknown status |
| - Coordinator of this site? Confirm its status | Bologna | Italy | Unknown status |
| - Coordinator of this site? Confirm its status | Genova | Italy | Unknown status |
| - Coordinator of this site? Confirm its status | Monza (mb) | Italy | Unknown status |
| - Coordinator of this site? Confirm its status | Naples | Italy | Unknown status |
| - Coordinator of this site? Confirm its status | Roma | Italy | Unknown status |
| - Coordinator of this site? Confirm its status | Rotterdam | Netherlands | Unknown status |
| - Coordinator of this site? Confirm its status | Utrecht | Netherlands | Unknown status |
| - Coordinator of this site? Confirm its status | Gdansk | Poland | Unknown status |
| - Coordinator of this site? Confirm its status | Krakow | Poland | Unknown status |
| Children's Healthcare of Atlanta Coordinator of this site? Confirm its status | Atlanta | United States | Unknown status |
| Childrens Hospital of Colorado Coordinator of this site? Confirm its status | Aurora | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Austin | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| Children's Hospital of Alabama Coordinator of this site? Confirm its status | Birmingham | United States | Unknown status |
| Dana-Farber Cancer Institute Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Buffalo | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Chapel Hill | United States | Unknown status |
| Carolinas Medical Center Coordinator of this site? Confirm its status | Charlotte | United States | Unknown status |
| Cincinnati Children's Hospital Medical Center Coordinator of this site? Confirm its status | Cincinnati | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Columbus | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Detroit | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Hackensack | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Hershey | United States | Unknown status |
| Baylor College of Medicine Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| University of Iowa Coordinator of this site? Confirm its status | Iowa City | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Jackson | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Jacksonville | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Kansas City | United States | Unknown status |
| Nevada Cancer Research Foundation Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Loma Linda University Cancer Center Coordinator of this site? Confirm its status | Loma Linda | United States | Unknown status |
| Valley Children's Hospital Coordinator of this site? Confirm its status | Madera | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Milwaukee | United States | Unknown status |
| Vanderbilt University Coordinator of this site? Confirm its status | Nashville | United States | Unknown status |
| - Coordinator of this site? Confirm its status | New Brunswick | United States | Unknown status |
| Smilow Cancer Hospital At Yale New Haven Hospital Coordinator of this site? Confirm its status | New Haven | United States | Unknown status |
| Children'S Hosp-Kings Daughter Coordinator of this site? Confirm its status | Norfolk | United States | Unknown status |
| Children'S Hospital & Research Center At Oakland Coordinator of this site? Confirm its status | Oakland | United States | Unknown status |
| University of Oklahoma Health Sciences Center Coordinator of this site? Confirm its status | Oklahoma City | United States | Unknown status |
| Children's Hospital of Orange County Coordinator of this site? Confirm its status | Orange | United States | Unknown status |
| Lucile Packard Children'S Research Hospital/Stanford Univ Coordinator of this site? Confirm its status | Palo Alto | United States | Unknown status |
| Childrens Hospital of Philadelphia Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| Phoenix Children s Hospital Coordinator of this site? Confirm its status | Phoenix | United States | Unknown status |
| Childrens Hospital Of Pittsburgh Of Upmc Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
| Virginia Commonwealth University Coordinator of this site? Confirm its status | Richmond | United States | Unknown status |
| Primary Children's Hospital Coordinator of this site? Confirm its status | Salt Lake City | United States | Unknown status |
| - Coordinator of this site? Confirm its status | San Diego | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Seattle | United States | Unknown status |
| Washington University School of Medicine Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| - Coordinator of this site? Confirm its status | St. Petersburg | United States | Unknown status |
| Children's National Medical Center Coordinator of this site? Confirm its status | Washington D.C. | United States | Unknown status |
| Nemours A. I. duPont Hospital for Children Coordinator of this site? Confirm its status | Wilmington | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.