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NCT02947347CompletedPhase 3

Study of Ibrutinib and Rituximab in Treatment Naïve Follicular Lymphoma

A Multicenter, Randomized, Double-blind, Placebo-controlled Phase 3 Study of the Bruton's Tyrosine Kinase (BTK) Inhibitor, Ibrutinib, in Combination With Rituximab Versus Placebo in Combination With Rituximab in Treatment Naïve Subjects With Follicular Lymphoma (PERSPECTIVE)

Source: ClinicalTrials.gov · Last updated 17 Mar 2026

Brief summary (registry, in English)

This is a randomized, double-blind, placebo-controlled, multicenter Phase 3 study to evaluate the efficacy and safety of ibrutinib in combination with rituximab versus placebo in combination with rituximab in treatment naïve participants with follicular lymphoma (FL).

Status (registry)
Completed
Phase (registry)
Phase 3
Study type
Interventional
Enrollment
445 (actual)
First submitted
26 Oct 2016
Start date
23 Jan 2017
Primary completion date
21 Feb 2024
Lead sponsor
Pharmacyclics LLC.
NCT number
NCT02947347
EU CT number
2023-507271-21-00
EudraCT number
2016-003202-14

What you commit to

  • Study type: Interventional · Phase 3
  • Participants enrolled: 445
  • From 23 Jan 2017 to the primary completion date, 21 Feb 2024
  • 123 sites in 19 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Prior treatment for follicular lymphoma.

Other illness

  • Central nervous system lymphoma or leptomeningeal disease.
  • Currently active, clinically significant cardiovascular disease.

Other

  • Transformed lymphoma

Who the study is looking for

  • Histologically confirmed diagnosis of follicular lymphoma CD20+ (Grade 1, 2 or 3a) Ann Arbor Stage II, III or IV disease.
  • Measurable disease
  • Subjects 70 years of age or older; OR subjects 60-69 years of age who have one or more comorbidities.
  • Meets one or more Groupe d'Etude des Lymphomes Folliculaire (GELF) criteria.
  • Adequate hematologic function within protocol-defined parameters.
  • Adequate hepatic and renal function within protocol-defined parameters.
  • ECOG performance status score of 0-2.

Age in the registry: 60 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (123)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Medizinische Universitaet Innsbruck
Coordinator of this site? Confirm its status
InnsbruckAustriaCompleted
Eb Haus Austria Gemeinnuetzige Salzburger Landeskliniken Betriebsgesellschaft mbH
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SalzburgAustriaCompleted
Monash Medical Centre Clayton Campus
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ClaytonAustraliaUnknown status
The Canberra Hospital
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GarranAustraliaUnknown status
Andrew Love Cancer Center
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GeelongAustraliaUnknown status
Royal Hobart Hospital
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HobartAustraliaUnknown status
Mater Misericordiae Health Services
Coordinator of this site? Confirm its status
South BrisbaneAustraliaUnknown status
Het Ziekenhuisnetwerk Antwerpen
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AntwerpBelgiumCompleted
GasthuisZusters Antwerpen
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AntwerpBelgiumCompleted
Az St-Jan Brugge-Oostende A.V.
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BruggeBelgiumCompleted
Universitair Ziekenhuis Gent
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GentBelgiumCompleted
CHU de Liège
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LiègeBelgiumCompleted
Cliniques Universitaires Saint-Luc
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Sint-Lambrechts-WoluweBelgiumCompleted
Vitaz
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Sint-NiklaasBelgiumCompleted
Moncton Hospital
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MonctonCanadaUnknown status
CIUSSS de l'Est-de-l'Île-de-Montréal
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MontrealCanadaUnknown status
CHUM Notre Dame Hospital
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MontrealCanadaUnknown status
Fakultni Nemocnice Hradec Kralove
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Novy Hradec KraloveCzechiaCompleted
Fakultni Nemocnice Ostrava
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PorubaCzechiaCompleted
Fakultní Nemocnice Královské Vinohrady
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Prague 10CzechiaCompleted
Fakultni Nemocnice V Motole
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Prague 5CzechiaCompleted
Hospital Germans Trias i Pujol
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BadalonaSpainCompleted
Hospital del Mar
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BarcelonaSpainCompleted
Hospital Universitari Vall d'Hebron
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BarcelonaSpainCompleted
Hospital Universitario de Cabueñes
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GijónSpainCompleted
Institut Catala D'oncologia
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L'Hospitalet de LlobregatSpainCompleted
Hospital Universitario HM Sanchinarro
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MadridSpainCompleted
Hospital Universitario Infanta Leonor
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MadridSpainCompleted
Hospital Universitario Virgen De Valme
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SevillaSpainCompleted
Hospital Arnau de Vilanova de Valencia
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ValenciaSpainCompleted
Hospital Clínico Universitario de Valladolid
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ValladolidSpainCompleted
Centre Hospitalier Et Universitaire De Limoges
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Limoges Cedex 1FranceCompleted
Centre Hospitalier de Perigueux
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PérigueuxFranceCompleted
Centre Hospitalier Universitaire de Bordeaux
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PessacFranceCompleted
Centre Hospitalier Universitaire de Poitiers
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PoitiersFranceCompleted
Centre Hospitalier Valence
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ValenceFranceCompleted
Addenbrooke's Hospital
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CambridgeUnited KingdomUnknown status
Leeds Teaching Hospitals NHS Trust
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LeedsUnited KingdomUnknown status
Barts and the London NHS Trust
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LondonUnited KingdomUnknown status
Norfolk and Norwich University Hospital
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NorwichUnited KingdomUnknown status
Derriford Hospital
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PlymouthUnited KingdomUnknown status
Royal Berkshire Hospital NHS Foundation Trust
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ReadingUnited KingdomUnknown status
Royal Cornwall Hospital - Hospital Treliske
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TruroUnited KingdomUnknown status
Laiko General Hospital of Athens
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AthensGreeceCompleted
General University Hospital of Larissa
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LarissaGreeceCompleted
General University Hospital Of Patras
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PatrasGreeceCompleted
Orszagos Onkologiai Intezet
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Budapest XIIHungaryCompleted
University of Debrecen
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DebrecenHungaryCompleted
Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz
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GyőrHungaryCompleted
Somogy Vármegyei Kaposi Mór Oktató Kórház
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KaposvárHungaryCompleted
University of Pecs
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PécsHungaryCompleted
Barzilai Medical Center
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AshkelonIsraelUnknown status
Bnei-Zion Medical Center
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HaifaIsraelUnknown status
Lady Davis Carmel Medical Center
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HaifaIsraelUnknown status
Rabin Medical Center-Beilinson Campus
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Petah TikvaIsraelUnknown status
Assuta Medical Center
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Tel AvivIsraelUnknown status
Assaf Harofe Medical Center
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TsrifinIsraelUnknown status
Centro di Riferimento Oncologico di Aviano
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AvianoItalyCompleted
Azienda Ospedaliera Santa Croce E Carle
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CuneoItalyCompleted
IRCCS Ospedale Policlinico San Martino
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GenoaItalyCompleted
Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST S.r.l
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MeldolaItalyCompleted
Ospedale San Raffaele S.r.l.
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MilanItalyCompleted
European Institute Of Oncology S.r.l.
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MilanItalyCompleted
Azienda Ospedaliero Universitaria Parma
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ParmaItalyCompleted
Azienda Unita Sanitaria Locale Della Romagna
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RiminiItalyCompleted
Fondazione Policlinico Universitario Campus Bio-Medico
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RomeItalyCompleted
Azienda Ospedaliero-Universitaria Policlinico Umberto I
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RomeItalyCompleted
Azienda Ospedaliera Universitaria Citta Della Salute E Della Scienza Di Torino
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TurinItalyCompleted
Gelre Hospitals
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ApeldoornNetherlandsCompleted
Leids Universitair Medisch Centrum (LUMC)
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LeidenNetherlandsCompleted
Maasstad Ziekenhuis Stichting
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RotterdamNetherlandsCompleted
St. Elisabeth Hospital Tilburg
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TilburgNetherlandsCompleted
Pratia S.A.
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CracowPolandCompleted
Copernicus Podmiot Leczniczy Sp. z o.o
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GdanskPolandCompleted
Szpitale Pomorskie Sp z o o
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GdyniaPolandCompleted
Centrum Onkologii Ziemi Lubelskiej im sw Jana z Dukli
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LublinPolandCompleted
Uniwersytecki Szpital Kliniczny im Jana Mikulicza Radeckiego we Wroclawiu
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WroclawPolandCompleted
Unidade Local de Saude de Sao Joao E.P.E.
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PortoPortugalCompleted
Instituto Portugues de Oncologia do Porto Francisco Gentil, E.P.E.
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PortoPortugalCompleted
Unidade Local De Saude De Santo Antonio E.P.E.
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PortoPortugalCompleted
Unidade Local De Saude De Matosinhos E.P.E.
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Senhora Da HoraPortugalCompleted
Regional Clinical Hospital
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KrasnoyarskRussiaUnknown status
Russian Oncology Research Center n a N N Blokhin
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MoscowRussiaUnknown status
Nizhegorodskaya Regional Clinical Hospital n.a. Semashko
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Nizhny NovgorodRussiaUnknown status
City Hospital #31
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Saint PetersburgRussiaUnknown status
North-West Federal Medical Research Center n.a. V.A. Almazov
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Saint PetersburgRussiaUnknown status
Kaohsiung Medical University Hospital
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Kaohsiung CityTaiwanUnknown status
Chang Gung Medical Foundation Kaohsiung Chang Gung Memorial Hospital
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Kaohsiung CityTaiwanUnknown status
Chi Mei Medical Center, Liouying
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LiuyingTaiwanUnknown status
Taipei Veterans General Hospital
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TaipeiTaiwanUnknown status
National Taiwan University Hospital
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TaipeiTaiwanUnknown status
OHSU Knight Cancer Institute Beaverton Clinic
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BeavertonUnited StatesUnknown status
Oncology and Hematology Associates of Southwest Virginia (Blacksburg)
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BlacksburgUnited StatesUnknown status
SCRI Tennessee Oncology Chattanooga
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ChattanoogaUnited StatesUnknown status
Rush University Medical Center
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ChicagoUnited StatesUnknown status
Texas Oncology - Medical City
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DallasUnited StatesUnknown status
Texas Oncology-Dallas Presbyterian Hospital
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DallasUnited StatesUnknown status
City of Hope
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DuarteUnited StatesUnknown status
SCRI Florida Cancer Specialists South
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Fort MyersUnited StatesUnknown status
SCRI The Center For Cancer and Blood Disorders
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Fort WorthUnited StatesUnknown status
Greenville Health System
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GreenvilleUnited StatesUnknown status
MD Anderson Cancer Center
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HoustonUnited StatesUnknown status
Goldschmidt Cancer Center
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Jefferson CityUnited StatesUnknown status
Southeast Nebraska Cancer Center
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LincolnUnited StatesUnknown status
Norton Cancer Institute
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LouisvilleUnited StatesUnknown status
Southern Cancer Center
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MobileUnited StatesUnknown status
W VA University Mary Babb Randolph Cancer Center
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MorgantownUnited StatesUnknown status
SCRI Tennessee Oncology - Nashville
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NashvilleUnited StatesUnknown status
Helen F. Graham Cancer Center and Research Institute
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NewarkUnited StatesUnknown status
Florida Cancer Affiliates
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OcalaUnited StatesUnknown status
Sansum Clinic
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Santa BarbaraUnited StatesUnknown status
UCLA Hematology/Oncology
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Santa MonicaUnited StatesUnknown status
Swedish Cancer Institute
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SeattleUnited StatesUnknown status
Medical Oncology Associates
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SpokaneUnited StatesUnknown status
SCRI Florida Cancer Specialists North
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St. PetersburgUnited StatesUnknown status
Texas Oncology - Tyler
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TylerUnited StatesUnknown status
Gazi Universitesi Tip Fakultesi Hastanesi
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AnkaraTurkey (Türkiye)Unknown status
Ege Universitesi Tip Fakultesi Hastanesi
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BornovaTurkey (Türkiye)Unknown status
Mersin Universitesi Tip Fakultesi Hastanesi
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GaziantepTurkey (Türkiye)Unknown status
Erciyes Universitesi Tip Fakultesi Hastanesi
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KayseriTurkey (Türkiye)Unknown status
Kocaeli Universitesi Tip Fakultesi Arastirma ve Uygulama Hastanesi
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KocaeliTurkey (Türkiye)Unknown status
Ondokuz Mayis Universitesi Tip Fakultesi Hastanesi
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SamsunTurkey (Türkiye)Unknown status
Namik Kemal Universitesi Tip Fakultesi Hastanesi
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TekirdağTurkey (Türkiye)Unknown status

This page is information, not medical advice. Discuss any trial with your doctor.