NCT02947347CompletedPhase 3
Study of Ibrutinib and Rituximab in Treatment Naïve Follicular Lymphoma
A Multicenter, Randomized, Double-blind, Placebo-controlled Phase 3 Study of the Bruton's Tyrosine Kinase (BTK) Inhibitor, Ibrutinib, in Combination With Rituximab Versus Placebo in Combination With Rituximab in Treatment Naïve Subjects With Follicular Lymphoma (PERSPECTIVE)
Source: ClinicalTrials.gov · Last updated 17 Mar 2026
Brief summary (registry, in English)
This is a randomized, double-blind, placebo-controlled, multicenter Phase 3 study to evaluate the efficacy and safety of ibrutinib in combination with rituximab versus placebo in combination with rituximab in treatment naïve participants with follicular lymphoma (FL).
- Status (registry)
- Completed
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 445 (actual)
- First submitted
- 26 Oct 2016
- Start date
- 23 Jan 2017
- Primary completion date
- 21 Feb 2024
- Lead sponsor
- Pharmacyclics LLC.
- Diseases
- Follicular lymphoma
- NCT number
- NCT02947347
- EU CT number
- 2023-507271-21-00
- EudraCT number
- 2016-003202-14
What you commit to
- Study type: Interventional · Phase 3
- Participants enrolled: 445
- From 23 Jan 2017 to the primary completion date, 21 Feb 2024
- 123 sites in 19 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior treatment for follicular lymphoma.
Other illness
- Central nervous system lymphoma or leptomeningeal disease.
- Currently active, clinically significant cardiovascular disease.
Other
- Transformed lymphoma
Who the study is looking for
- Histologically confirmed diagnosis of follicular lymphoma CD20+ (Grade 1, 2 or 3a) Ann Arbor Stage II, III or IV disease.
- Measurable disease
- Subjects 70 years of age or older; OR subjects 60-69 years of age who have one or more comorbidities.
- Meets one or more Groupe d'Etude des Lymphomes Folliculaire (GELF) criteria.
- Adequate hematologic function within protocol-defined parameters.
- Adequate hepatic and renal function within protocol-defined parameters.
- ECOG performance status score of 0-2.
Age in the registry: 60 years to - · Sex: All · Does not accept healthy volunteers
Sites (123)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Medizinische Universitaet Innsbruck Coordinator of this site? Confirm its status | Innsbruck | Austria | Completed |
| Eb Haus Austria Gemeinnuetzige Salzburger Landeskliniken Betriebsgesellschaft mbH Coordinator of this site? Confirm its status | Salzburg | Austria | Completed |
| Monash Medical Centre Clayton Campus Coordinator of this site? Confirm its status | Clayton | Australia | Unknown status |
| The Canberra Hospital Coordinator of this site? Confirm its status | Garran | Australia | Unknown status |
| Andrew Love Cancer Center Coordinator of this site? Confirm its status | Geelong | Australia | Unknown status |
| Royal Hobart Hospital Coordinator of this site? Confirm its status | Hobart | Australia | Unknown status |
| Mater Misericordiae Health Services Coordinator of this site? Confirm its status | South Brisbane | Australia | Unknown status |
| Het Ziekenhuisnetwerk Antwerpen Coordinator of this site? Confirm its status | Antwerp | Belgium | Completed |
| GasthuisZusters Antwerpen Coordinator of this site? Confirm its status | Antwerp | Belgium | Completed |
| Az St-Jan Brugge-Oostende A.V. Coordinator of this site? Confirm its status | Brugge | Belgium | Completed |
| Universitair Ziekenhuis Gent Coordinator of this site? Confirm its status | Gent | Belgium | Completed |
| CHU de Liège Coordinator of this site? Confirm its status | Liège | Belgium | Completed |
| Cliniques Universitaires Saint-Luc Coordinator of this site? Confirm its status | Sint-Lambrechts-Woluwe | Belgium | Completed |
| Vitaz Coordinator of this site? Confirm its status | Sint-Niklaas | Belgium | Completed |
| Moncton Hospital Coordinator of this site? Confirm its status | Moncton | Canada | Unknown status |
| CIUSSS de l'Est-de-l'Île-de-Montréal Coordinator of this site? Confirm its status | Montreal | Canada | Unknown status |
| CHUM Notre Dame Hospital Coordinator of this site? Confirm its status | Montreal | Canada | Unknown status |
| Fakultni Nemocnice Hradec Kralove Coordinator of this site? Confirm its status | Novy Hradec Kralove | Czechia | Completed |
| Fakultni Nemocnice Ostrava Coordinator of this site? Confirm its status | Poruba | Czechia | Completed |
| Fakultní Nemocnice Královské Vinohrady Coordinator of this site? Confirm its status | Prague 10 | Czechia | Completed |
| Fakultni Nemocnice V Motole Coordinator of this site? Confirm its status | Prague 5 | Czechia | Completed |
| Hospital Germans Trias i Pujol Coordinator of this site? Confirm its status | Badalona | Spain | Completed |
| Hospital del Mar Coordinator of this site? Confirm its status | Barcelona | Spain | Completed |
| Hospital Universitari Vall d'Hebron Coordinator of this site? Confirm its status | Barcelona | Spain | Completed |
| Hospital Universitario de Cabueñes Coordinator of this site? Confirm its status | Gijón | Spain | Completed |
| Institut Catala D'oncologia Coordinator of this site? Confirm its status | L'Hospitalet de Llobregat | Spain | Completed |
| Hospital Universitario HM Sanchinarro Coordinator of this site? Confirm its status | Madrid | Spain | Completed |
| Hospital Universitario Infanta Leonor Coordinator of this site? Confirm its status | Madrid | Spain | Completed |
| Hospital Universitario Virgen De Valme Coordinator of this site? Confirm its status | Sevilla | Spain | Completed |
| Hospital Arnau de Vilanova de Valencia Coordinator of this site? Confirm its status | Valencia | Spain | Completed |
| Hospital Clínico Universitario de Valladolid Coordinator of this site? Confirm its status | Valladolid | Spain | Completed |
| Centre Hospitalier Et Universitaire De Limoges Coordinator of this site? Confirm its status | Limoges Cedex 1 | France | Completed |
| Centre Hospitalier de Perigueux Coordinator of this site? Confirm its status | Périgueux | France | Completed |
| Centre Hospitalier Universitaire de Bordeaux Coordinator of this site? Confirm its status | Pessac | France | Completed |
| Centre Hospitalier Universitaire de Poitiers Coordinator of this site? Confirm its status | Poitiers | France | Completed |
| Centre Hospitalier Valence Coordinator of this site? Confirm its status | Valence | France | Completed |
| Addenbrooke's Hospital Coordinator of this site? Confirm its status | Cambridge | United Kingdom | Unknown status |
| Leeds Teaching Hospitals NHS Trust Coordinator of this site? Confirm its status | Leeds | United Kingdom | Unknown status |
| Barts and the London NHS Trust Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| Norfolk and Norwich University Hospital Coordinator of this site? Confirm its status | Norwich | United Kingdom | Unknown status |
| Derriford Hospital Coordinator of this site? Confirm its status | Plymouth | United Kingdom | Unknown status |
| Royal Berkshire Hospital NHS Foundation Trust Coordinator of this site? Confirm its status | Reading | United Kingdom | Unknown status |
| Royal Cornwall Hospital - Hospital Treliske Coordinator of this site? Confirm its status | Truro | United Kingdom | Unknown status |
| Laiko General Hospital of Athens Coordinator of this site? Confirm its status | Athens | Greece | Completed |
| General University Hospital of Larissa Coordinator of this site? Confirm its status | Larissa | Greece | Completed |
| General University Hospital Of Patras Coordinator of this site? Confirm its status | Patras | Greece | Completed |
| Orszagos Onkologiai Intezet Coordinator of this site? Confirm its status | Budapest XII | Hungary | Completed |
| University of Debrecen Coordinator of this site? Confirm its status | Debrecen | Hungary | Completed |
| Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz Coordinator of this site? Confirm its status | Győr | Hungary | Completed |
| Somogy Vármegyei Kaposi Mór Oktató Kórház Coordinator of this site? Confirm its status | Kaposvár | Hungary | Completed |
| University of Pecs Coordinator of this site? Confirm its status | Pécs | Hungary | Completed |
| Barzilai Medical Center Coordinator of this site? Confirm its status | Ashkelon | Israel | Unknown status |
| Bnei-Zion Medical Center Coordinator of this site? Confirm its status | Haifa | Israel | Unknown status |
| Lady Davis Carmel Medical Center Coordinator of this site? Confirm its status | Haifa | Israel | Unknown status |
| Rabin Medical Center-Beilinson Campus Coordinator of this site? Confirm its status | Petah Tikva | Israel | Unknown status |
| Assuta Medical Center Coordinator of this site? Confirm its status | Tel Aviv | Israel | Unknown status |
| Assaf Harofe Medical Center Coordinator of this site? Confirm its status | Tsrifin | Israel | Unknown status |
| Centro di Riferimento Oncologico di Aviano Coordinator of this site? Confirm its status | Aviano | Italy | Completed |
| Azienda Ospedaliera Santa Croce E Carle Coordinator of this site? Confirm its status | Cuneo | Italy | Completed |
| IRCCS Ospedale Policlinico San Martino Coordinator of this site? Confirm its status | Genoa | Italy | Completed |
| Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST S.r.l Coordinator of this site? Confirm its status | Meldola | Italy | Completed |
| Ospedale San Raffaele S.r.l. Coordinator of this site? Confirm its status | Milan | Italy | Completed |
| European Institute Of Oncology S.r.l. Coordinator of this site? Confirm its status | Milan | Italy | Completed |
| Azienda Ospedaliero Universitaria Parma Coordinator of this site? Confirm its status | Parma | Italy | Completed |
| Azienda Unita Sanitaria Locale Della Romagna Coordinator of this site? Confirm its status | Rimini | Italy | Completed |
| Fondazione Policlinico Universitario Campus Bio-Medico Coordinator of this site? Confirm its status | Rome | Italy | Completed |
| Azienda Ospedaliero-Universitaria Policlinico Umberto I Coordinator of this site? Confirm its status | Rome | Italy | Completed |
| Azienda Ospedaliera Universitaria Citta Della Salute E Della Scienza Di Torino Coordinator of this site? Confirm its status | Turin | Italy | Completed |
| Gelre Hospitals Coordinator of this site? Confirm its status | Apeldoorn | Netherlands | Completed |
| Leids Universitair Medisch Centrum (LUMC) Coordinator of this site? Confirm its status | Leiden | Netherlands | Completed |
| Maasstad Ziekenhuis Stichting Coordinator of this site? Confirm its status | Rotterdam | Netherlands | Completed |
| St. Elisabeth Hospital Tilburg Coordinator of this site? Confirm its status | Tilburg | Netherlands | Completed |
| Pratia S.A. Coordinator of this site? Confirm its status | Cracow | Poland | Completed |
| Copernicus Podmiot Leczniczy Sp. z o.o Coordinator of this site? Confirm its status | Gdansk | Poland | Completed |
| Szpitale Pomorskie Sp z o o Coordinator of this site? Confirm its status | Gdynia | Poland | Completed |
| Centrum Onkologii Ziemi Lubelskiej im sw Jana z Dukli Coordinator of this site? Confirm its status | Lublin | Poland | Completed |
| Uniwersytecki Szpital Kliniczny im Jana Mikulicza Radeckiego we Wroclawiu Coordinator of this site? Confirm its status | Wroclaw | Poland | Completed |
| Unidade Local de Saude de Sao Joao E.P.E. Coordinator of this site? Confirm its status | Porto | Portugal | Completed |
| Instituto Portugues de Oncologia do Porto Francisco Gentil, E.P.E. Coordinator of this site? Confirm its status | Porto | Portugal | Completed |
| Unidade Local De Saude De Santo Antonio E.P.E. Coordinator of this site? Confirm its status | Porto | Portugal | Completed |
| Unidade Local De Saude De Matosinhos E.P.E. Coordinator of this site? Confirm its status | Senhora Da Hora | Portugal | Completed |
| Regional Clinical Hospital Coordinator of this site? Confirm its status | Krasnoyarsk | Russia | Unknown status |
| Russian Oncology Research Center n a N N Blokhin Coordinator of this site? Confirm its status | Moscow | Russia | Unknown status |
| Nizhegorodskaya Regional Clinical Hospital n.a. Semashko Coordinator of this site? Confirm its status | Nizhny Novgorod | Russia | Unknown status |
| City Hospital #31 Coordinator of this site? Confirm its status | Saint Petersburg | Russia | Unknown status |
| North-West Federal Medical Research Center n.a. V.A. Almazov Coordinator of this site? Confirm its status | Saint Petersburg | Russia | Unknown status |
| Kaohsiung Medical University Hospital Coordinator of this site? Confirm its status | Kaohsiung City | Taiwan | Unknown status |
| Chang Gung Medical Foundation Kaohsiung Chang Gung Memorial Hospital Coordinator of this site? Confirm its status | Kaohsiung City | Taiwan | Unknown status |
| Chi Mei Medical Center, Liouying Coordinator of this site? Confirm its status | Liuying | Taiwan | Unknown status |
| Taipei Veterans General Hospital Coordinator of this site? Confirm its status | Taipei | Taiwan | Unknown status |
| National Taiwan University Hospital Coordinator of this site? Confirm its status | Taipei | Taiwan | Unknown status |
| OHSU Knight Cancer Institute Beaverton Clinic Coordinator of this site? Confirm its status | Beaverton | United States | Unknown status |
| Oncology and Hematology Associates of Southwest Virginia (Blacksburg) Coordinator of this site? Confirm its status | Blacksburg | United States | Unknown status |
| SCRI Tennessee Oncology Chattanooga Coordinator of this site? Confirm its status | Chattanooga | United States | Unknown status |
| Rush University Medical Center Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| Texas Oncology - Medical City Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Texas Oncology-Dallas Presbyterian Hospital Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| City of Hope Coordinator of this site? Confirm its status | Duarte | United States | Unknown status |
| SCRI Florida Cancer Specialists South Coordinator of this site? Confirm its status | Fort Myers | United States | Unknown status |
| SCRI The Center For Cancer and Blood Disorders Coordinator of this site? Confirm its status | Fort Worth | United States | Unknown status |
| Greenville Health System Coordinator of this site? Confirm its status | Greenville | United States | Unknown status |
| MD Anderson Cancer Center Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| Goldschmidt Cancer Center Coordinator of this site? Confirm its status | Jefferson City | United States | Unknown status |
| Southeast Nebraska Cancer Center Coordinator of this site? Confirm its status | Lincoln | United States | Unknown status |
| Norton Cancer Institute Coordinator of this site? Confirm its status | Louisville | United States | Unknown status |
| Southern Cancer Center Coordinator of this site? Confirm its status | Mobile | United States | Unknown status |
| W VA University Mary Babb Randolph Cancer Center Coordinator of this site? Confirm its status | Morgantown | United States | Unknown status |
| SCRI Tennessee Oncology - Nashville Coordinator of this site? Confirm its status | Nashville | United States | Unknown status |
| Helen F. Graham Cancer Center and Research Institute Coordinator of this site? Confirm its status | Newark | United States | Unknown status |
| Florida Cancer Affiliates Coordinator of this site? Confirm its status | Ocala | United States | Unknown status |
| Sansum Clinic Coordinator of this site? Confirm its status | Santa Barbara | United States | Unknown status |
| UCLA Hematology/Oncology Coordinator of this site? Confirm its status | Santa Monica | United States | Unknown status |
| Swedish Cancer Institute Coordinator of this site? Confirm its status | Seattle | United States | Unknown status |
| Medical Oncology Associates Coordinator of this site? Confirm its status | Spokane | United States | Unknown status |
| SCRI Florida Cancer Specialists North Coordinator of this site? Confirm its status | St. Petersburg | United States | Unknown status |
| Texas Oncology - Tyler Coordinator of this site? Confirm its status | Tyler | United States | Unknown status |
| Gazi Universitesi Tip Fakultesi Hastanesi Coordinator of this site? Confirm its status | Ankara | Turkey (Türkiye) | Unknown status |
| Ege Universitesi Tip Fakultesi Hastanesi Coordinator of this site? Confirm its status | Bornova | Turkey (Türkiye) | Unknown status |
| Mersin Universitesi Tip Fakultesi Hastanesi Coordinator of this site? Confirm its status | Gaziantep | Turkey (Türkiye) | Unknown status |
| Erciyes Universitesi Tip Fakultesi Hastanesi Coordinator of this site? Confirm its status | Kayseri | Turkey (Türkiye) | Unknown status |
| Kocaeli Universitesi Tip Fakultesi Arastirma ve Uygulama Hastanesi Coordinator of this site? Confirm its status | Kocaeli | Turkey (Türkiye) | Unknown status |
| Ondokuz Mayis Universitesi Tip Fakultesi Hastanesi Coordinator of this site? Confirm its status | Samsun | Turkey (Türkiye) | Unknown status |
| Namik Kemal Universitesi Tip Fakultesi Hastanesi Coordinator of this site? Confirm its status | Tekirdağ | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.