NCT02967848Active, not recruiting
Liver Function Investigation With SPECT
Liver Function Investigation With Single Photon Emission Computed Tomography After Radiotherapy
Source: ClinicalTrials.gov · Last updated 5 Feb 2026
Brief summary (registry, in English)
This is a Phase 1 pilot study to assess feasibility and utility of 99mTc-mebrofenin hepatobiliary scintigraphy for measurement of functional liver change due to radiotherapy.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 20 (estimated)
- First submitted
- 16 Nov 2016
- Start date
- 19 Oct 2016
- Primary completion date
- Dec 2020
- Lead sponsor
- Royal North Shore Hospital
- Diseases
- Liver and biliary tract cancer
- NCT number
- NCT02967848
What you commit to
- Study type: Observational
- Planned participants: 20
- From 19 Oct 2016 to the primary completion date, Dec 2020
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous high-dose radiotherapy to the liver
- Previous SIRT
Other illness
- History of allergic reactions attributed to compounds of similar chemical or biologic composition to indocyanine green, including those patients with a history of iodide or seafood allergy (excluded from ICG testing only)
Other
- Women who are pregnant or lactating
- Unwilling or unable to give informed consent
- No venous access
- Inability to lie supine and still for 30 minutes
- Pacemaker (excluded from Fibroscan elasticity test only)
Who the study is looking for
- Aged 18 or older
- Has provided written Informed Consent for participation in this trial and is willing to comply with the study
- Patients undergoing external beam radiotherapy at Northern Sydney Cancer Centre
- Histologically proven hepatocellular carcinoma or oligometastatic liver metastases (3 or less). Histological diagnosis will be obtained if clinically indicated.
- ECOG performance status 0-2
Age in the registry: 18 years to 100 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Royal North Shore Hospital Coordinator of this site? Confirm its status | St Leonards | Australia | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.