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NCT02978521Recruiting

Pulmonary Rehabilitation in Advanced Non-small Cell Lung Cancer Patients

Effect of a Pulmonary Rehabilitation Program on Skeletal Muscle Mass, Pulmonary Function, Inflammatory Response and Overall Survival on Patients Diagnosed With Non-small-cell Advanced Cancer

Source: ClinicalTrials.gov · Last updated 8 Apr 2026

Brief summary (registry, in English)

Lung cancer (LC) is usually diagnosed in advanced stages and continues to be the leading cause of cancer related deaths worldwide. Cancer cachexia are frequent among patients with LC affecting up to 80% of patients with advanced stage disease, and it has been related with higher risk of complications, length of hospital stay, and worst overall survival. During cancer cachexia, both muscle and fat mass can be wasted, however, the loss of muscle mass has been associated to higher treatment related toxicity, loss of functional status, shorter progression free survival and overall survival in different types of cancer under various treatments. Hence, preservation of muscle mass and function should be an important focus of the multidisciplinary treatment of patients with LC. Pulmonary rehabilitation (PR) has been known to improve pulmonary function, reduce fatigue and improve exercise tolerance in patients with LC undergoing curative surgery. However, few studies have focused on the efficacy of PR on patients with advanced cancer undergoing palliative care with chemotherapy or targeted therapies.

Status (registry)
Recruiting
Study type
Interventional
Enrollment
94 (estimated)
First submitted
18 Nov 2016
Start date
5 Aug 2016
Primary completion date
5 Dec 2026
Lead sponsor
Instituto Nacional de Cancerologia de Mexico
Diseases
Lung cancer
NCT number
NCT02978521

What you commit to

  • Study type: Interventional
  • Planned participants: 94
  • From 5 Aug 2016 to the primary completion date, 5 Dec 2026
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study design.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Not residents of Mexico City or unable to attend to therapy sessions

Other illness

  • Uncontrolled hypertension (\>140/100mmHg)

Other

  • Symptomatic brain metastasis
  • Uncontrolled pain (Visual Analog Scale \>5)
  • Practice of regular moderate to intense physical activity at least 3 day/week

Who the study is looking for

  • Confirmed diagnosis of advanced non-small-cell lung cancer
  • Good performance status (ECOG 0-1)
  • Life expectancy \>12 weeks
  • Eligible to receive treatment with chemotherapy or tyrosinkinase inhibitors
  • Recent electrocardiogram without evidence of arrythmia

Age in the registry: 18 years to 70 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Save your city in your profile to sort them by distance.

SiteCityCountrySite status
Instituto Nacional de Cancerologia
Coordinator of this site? Confirm its status
Mexico CityMexicoRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.