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NCT03003962Active, not recruitingPhase 3

Study of Durvalumab Alone or Chemotherapy for Patients With Advanced Non Small-Cell Lung Cancer (PEARL)

A Phase III Randomized, Open-Label, Multi-Center Study of Durvalumab (MEDI4736) Versus Standard of Care (SoC) Platinum-Based Chemotherapy as First Line Treatment in Patients With PD-L1-High Expression Advanced Non Small-Cell Lung Cancer

Source: ClinicalTrials.gov · Last updated 11 Jun 2026

Brief summary (registry, in English)

This is a randomized, open-label, multi-center Phase III study to determine the efficacy and safety of durvalumab versus platinum-based SoC chemotherapy in the first-line treatment of advanced NSCLC in patients who are epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) wild-type and with PD-L1 high expression (PEARL)

Status (registry)
Active, not recruiting
Phase (registry)
Phase 3
Study type
Interventional
Enrollment
669 (actual)
First submitted
15 Dec 2016
Start date
2 Jan 2017
Primary completion date
27 Oct 2022
Lead sponsor
AstraZeneca
Diseases
Lung cancer
NCT number
NCT03003962
EudraCT number
2018-001375-21

What you commit to

  • Study type: Interventional · Phase 3
  • Participants enrolled: 669
  • From 2 Jan 2017 to the primary completion date, 27 Oct 2022
  • 69 sites in 12 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Prior chemotherapy or any other systemic therapy for advanced NSCLC
  • Brain metastases or spinal cord compression unless the patient is stable and off steroids for at least 14 days prior to start of study treatment
  • Active or prior documented autoimmune or inflammatory disorders (e.g., colitis or Crohn's disease\]

Other illness

  • Mixed small-cell lung cancer and NSCLC histology, sarcomatoid variant

Lab values

  • Prior exposure to immune-mediated therapy, including, but not limited to, other anti-cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), anti-programmed cell death1 (PD-1), anti-programmed cell death ligand 1 (PD-L1), or anti PD-L2 antibodies, excluding therapeutic anticancer vaccines

Who the study is looking for

  • Aged at least 18 years
  • Documented evidence of Stage IV NSCLC
  • No sensitizing EGFR mutation and ALK rearrangement
  • PD-L1 high expression
  • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1

Age in the registry: 18 years to 130 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (69)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
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Box HillAustraliaUnknown status
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GosfordAustraliaUnknown status
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KogarahAustraliaUnknown status
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St LeonardsAustraliaUnknown status
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BeijingChinaUnknown status
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BengbuChinaUnknown status
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ChangchunChinaUnknown status
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ChangshaChinaUnknown status
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ChengduChinaUnknown status
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ChongqingChinaUnknown status
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GuangzhouChinaUnknown status
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HaikouChinaUnknown status
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HangzhouChinaUnknown status
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JinanChinaUnknown status
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LinhaiChinaUnknown status
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NanchangChinaUnknown status
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NanjingChinaUnknown status
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NingboChinaUnknown status
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ShanghaiChinaUnknown status
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ShenyangChinaUnknown status
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ShijiazhuangChinaUnknown status
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ÜrümqiChinaUnknown status
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WanzhouChinaUnknown status
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WenzhouChinaUnknown status
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WuhanChinaUnknown status
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Xi'anChinaUnknown status
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ZhengzhouChinaUnknown status
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ZhuhaiChinaUnknown status
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BudapestHungaryUnknown status
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DeszkHungaryUnknown status
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FarkasgyepüHungaryUnknown status
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Gyöngyös - MátraházaHungaryUnknown status
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SzékesfehérvárHungaryUnknown status
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TörökbálintHungaryUnknown status
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Changwon-siSouth KoreaUnknown status
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Cheongju-siSouth KoreaUnknown status
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DaeguSouth KoreaUnknown status
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IncheonSouth KoreaUnknown status
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JinjuSouth KoreaUnknown status
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SeoulSouth KoreaUnknown status
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SuwonSouth KoreaUnknown status
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AlmeloNetherlandsUnknown status
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BialystokPolandUnknown status
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GrudziądzPolandUnknown status
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KoszalinPolandUnknown status
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LublinPolandUnknown status
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MrozyPolandUnknown status
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WarsawPolandUnknown status
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WroclawPolandUnknown status
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ArkhangelskRussiaUnknown status
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MoscowRussiaUnknown status
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NovosibirskRussiaUnknown status
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OmskRussiaUnknown status
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Rostov-on-DonRussiaUnknown status
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Saint PetersburgRussiaUnknown status
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VolgogradRussiaUnknown status
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BangkokThailandUnknown status
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MuangThailandUnknown status
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SongkhlaThailandUnknown status
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TaichungTaiwanUnknown status
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TaipeiTaiwanUnknown status
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AnaheimUnited StatesUnknown status
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Can ThoVietnamUnknown status
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HanoiVietnamUnknown status
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Ho Chi Minh CityVietnamUnknown status
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AnkaraTurkey (Türkiye)Unknown status
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IstanbulTurkey (Türkiye)Unknown status
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MalatyaTurkey (Türkiye)Unknown status
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PamukkaleTurkey (Türkiye)Unknown status

This page is information, not medical advice. Discuss any trial with your doctor.