NCT03012022Active, not recruiting
Cleveland Heart and Metabolic Prevention Study
Nitrative Stress in Heart Failure: The Cleveland Heart and Metabolic Prevention Study (CHAMPS)
Source: ClinicalTrials.gov · Last updated 25 Jun 2026
Brief summary (registry, in English)
The purpose of this research study is to investigate the role of chemical reactions, such as inflammation and oxidation, in the cause of cardiac dysfunction (the heart does not function properly). The investigators are interested in studying the various chemical pathways for cell damage to determine which are the most prevalent and/or most important. The investigators also want to determine whether waste products of oxidative damage or other chemicals can be monitored in the blood or urine and serve as an indication of the existence and severity of overall heart disease activity. The investigators further want to determine whether certain proteins, called enzymes, affect this cell damage, or whether the presence or absence of certain genes which create different forms of these enzymes correlate with the development of heart failure or cardiomyopathy (weakening of the heart muscle or a change in heart muscle structure) or other cardiovascular diseases.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 1208 (actual)
- First submitted
- 15 Dec 2016
- Start date
- 8 Nov 2010
- Primary completion date
- 30 Jun 2027
- Lead sponsor
- The Cleveland Clinic
- Diseases
- Heart failure
- NCT number
- NCT03012022
What you commit to
- Study type: Observational
- Participants enrolled: 1208
- From 8 Nov 2010 to the primary completion date, 30 Jun 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Major cardiovascular event (myocardial infarction, unstable angina, stroke, transient ischemic attack, pulmonary embolism), or major surgery \<1 month of enrollment of present study (subject can be considered enrollment after 1 month if deemed clinically stable)
Lab values
- Known history of heart failure or cardiomyopathy (LVSD, defined by left ventricular ejection fraction ≤45%) at the time of enrollment
Other
- Any hospitalization or emergency room visits for any cause \<1 month of enrollment present study
- Known life expectancy \<6 months at the time of enrollment.
Who the study is looking for
- Either age 40 years or older OR age 18 years or older with a family history of heart failure or cardiac dysfunction (the heart does not function properly).
- Able and willing to consent to the study protocol, including an overnight (≥10 hour) fast.
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Cleveland Clinic Coordinator of this site? Confirm its status | Cleveland | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.