NCT03026998Active, not recruiting
MRI Screening of Second Primary Cancer Occurring Within Radiation Fields After Treatment by External Beam Radiation Therapy for Hereditary Retinoblastoma (DepiSCARRH)
MRI Screening of Second Primary Cancer Occurring Within Radiation Fields After Treatment by External Beam Radiation Therapy for Hereditary Retinoblastoma
Source: ClinicalTrials.gov · Last updated 15 Sept 2025
Brief summary (registry, in English)
The purpose of this study is to assess the benefit of MR screening for asymptomatic head \& neck (or CNS) second primary cancers occurring in hereditary retinoblastoma patients previously treated by external beam radiation therapy (EBRT).
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 88 (actual)
- First submitted
- 6 Jan 2017
- Start date
- 19 Mar 2017
- Primary completion date
- 31 Mar 2034
- Lead sponsor
- Institut Curie
- Diseases
- Childhood cancers
- NCT number
- NCT03026998
What you commit to
- Study type: Interventional
- Participants enrolled: 88
- From 19 Mar 2017 to the primary completion date, 31 Mar 2034
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Personal history of non-familial unilateral unifocal retinoblastoma without RB1 germline mutation.
- Personal history of second primary neoplasm occurring within radiation fields
- Contraindication for MRI (pacemaker, intraocular metallic foreign body, defibrillators or other implanted electronic devices, intracranial ferro-magnetic clips) or associated conditions preventing from MR examination (intraocular prostheses and implants are not a contraindication for MRI; orthodontic metallic devices are not a contraindication but might decrease the image quality and should be removed, if possible)
Other
- Patients unable to comply with follow-up study requirements, for any geographical, social or psychological reason
Who the study is looking for
- Personal history of hereditary retinoblastoma (i.e., familial history of retinoblastoma, or bilateral retinoblastoma, or unilateral multifocal retinoblastoma, or identified germline RB1 mutation or 13q deletion)
- External beam radiation therapy (EBRT) used for retinoblastoma treatment
- Age at inclusion greater or equal to 7 years old.
- Time period between the end of EBRT and inclusion date of 5 years or more
- Written informed consent signed by patient (or legal representative)
Age in the registry: 7 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Institut Curie Coordinator of this site? Confirm its status | Paris | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.