NCT03032627Active, not recruiting
Identifying Targets of Maladaptive Metabolic Responses in Heart Failure
Source: ClinicalTrials.gov · Last updated 13 Mar 2025
Brief summary (registry, in English)
The purpose of the research is to help researchers understand changes in metabolism in patients that develop heart failure.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 55 (actual)
- First submitted
- 17 Jan 2017
- Start date
- 20 Mar 2017
- Primary completion date
- 28 Jun 2019
- Lead sponsor
- AdventHealth Translational Research Institute
- Diseases
- Heart failure
- NCT number
- NCT03032627
What you commit to
- Study type: Interventional
- Participants enrolled: 55
- From 20 Mar 2017 to the primary completion date, 28 Jun 2019
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Samples collected from non-failing hearts deemed unsuitable for transplantation by TransLife because of either acute recipient issues or post-harvest evidence of pathology or positive but benign serology.
Other illness
- Normal cardiac function from medical records
- Abnormal or impaired cardiac function from medical records, which are self determinants for rejection as a donor organ.
Lab values
- Diagnosed with following co-morbidities: cancer, chronic kidney disease (GFR≤30 or serum creatinine \>2.1), active infection or treatment with antibiotics or persistent infectious disease (hepatitis, HIV, etc), cirrhosis, active substance abuse and/or alcohol dependence (≥ 14 alcoholic beverages per week).
- Control Myocardial Tissue from Donor Hearts Inclusion Criteria
Other
- Life expectancy less than 2 weeks
- Pathological remodeling and extensive infarction with limited non-pathological regions of myocardium.
Who the study is looking for
- Subjects are capable of giving informed consent.
- Age 19-89
- Diagnosis of chronic heart failure
- Any patients scheduled for at least one of the following procedures:
- LVAD implantation or as recipient for cardiac transplantation.
- LVAD placement both as bridge to transplant and as destination therapy.
- LVAD explantation
- Valve replacement or repair
- Catheterization and myocardial biopsy for idiopathic cardiomyopathy
- Coronary artery bypass graft (CABG)
Age in the registry: 19 years to 89 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Translational Research Institute for Metabolism and Diabetes Coordinator of this site? Confirm its status | Orlando | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.