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NCT03043872Active, not recruitingPhase 3

Durvalumab ± Tremelimumab in Combination With Platinum Based Chemotherapy in Untreated Extensive-Stage Small Cell Lung Cancer (CASPIAN)

A Phase III, Randomized, Multicenter,Open-Label, Comparative Study to Determine the Efficacy of Durvalumab or Durvalumab and Tremelimumab in Combination With Platinum-Based Chemotherapy for the First-Line Treatment in Patients With Extensive Disease Small-Cell Lung Cancer (SCLC) (CASPIAN)

Source: ClinicalTrials.gov · Last updated 16 Jul 2026

Brief summary (registry, in English)

This is a phase III, randomized, open-label, multicenter, global study to determine the efficacy and safety of combining durvalumab ± tremelimumab with platinum based chemotherapy (EP) followed by durvalumab ± tremelimumab maintenance therapy versus EP alone as first-line treatment in patients with extensive-stage small-cell lung cancer

Status (registry)
Active, not recruiting
Phase (registry)
Phase 3
Study type
Interventional
Enrollment
987 (actual)
First submitted
18 Jan 2017
Start date
27 Mar 2017
Primary completion date
27 Jan 2020
Lead sponsor
AstraZeneca
Diseases
Lung cancer
NCT number
NCT03043872
EudraCT number
2016-001203-23

What you commit to

  • Study type: Interventional · Phase 3
  • Participants enrolled: 987
  • From 27 Mar 2017 to the primary completion date, 27 Jan 2020
  • 171 sites in 23 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Any history of radiotherapy to the chest prior to systemic therapy or planned consolidation chest radiation therapy (except paliative care outside of the chest).
  • Active or prior documented autoimmune or inflammatory disorders

Other illness

  • Paraneoplastic syndrome of autoimmune nature, requiring systemic treatment or clinical symptomatology suggesting worsening of PNS
  • Uncontrolled intercurrent illness, including but not limited to interstitial lung disease.

Lab values

  • Active infection including tuberculosis, HIV, hepatitis B anc C

Who the study is looking for

  • Histologically or cytologically documented extensive disease. Brain metastases; must be asymptomatic or treated and stable off steroids and anti-convulsants for at least 1 month prior to study treatment.
  • Suitable to receive a platinum-based chemotherapy regimen as 1st line treatment.
  • Life expectancy ≥12 weeks at Day 1.
  • ECOG 0 or 1 at enrolment.
  • No prior exposure to immune-mediated therapy excluding therapeutic anticancer vaccines.

Age in the registry: 18 years to 130 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (171)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
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Buenos AiresArgentinaUnknown status
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Ciudad de Buenos AiresArgentinaUnknown status
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Mar del PlataArgentinaUnknown status
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RosarioArgentinaUnknown status
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San Miguel de TucumánArgentinaUnknown status
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LinzAustriaUnknown status
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SalzburgAustriaUnknown status
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ViennaAustriaUnknown status
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PanagyurishteBulgariaUnknown status
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PlovdivBulgariaUnknown status
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SofiaBulgariaUnknown status
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VarnaBulgariaUnknown status
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BarretosBrazilUnknown status
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CuritibaBrazilUnknown status
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Passo FundoBrazilUnknown status
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Porto AlegreBrazilUnknown status
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Ribeirão PretoBrazilUnknown status
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Rio de JaneiroBrazilUnknown status
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SalvadorBrazilUnknown status
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Santo AndréBrazilUnknown status
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São José do Rio PretoBrazilUnknown status
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São PauloBrazilUnknown status
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BeijingChinaUnknown status
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BengbuChinaUnknown status
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ChangchunChinaUnknown status
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ChangshaChinaUnknown status
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ChengduChinaUnknown status
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ChongqingChinaUnknown status
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HangzhouChinaUnknown status
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HefeiChinaUnknown status
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NanchangChinaUnknown status
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NanjingChinaUnknown status
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ShanghaiChinaUnknown status
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ShenyangChinaUnknown status
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ÜrümqiChinaUnknown status
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WenzhouChinaUnknown status
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WuhanChinaUnknown status
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Xi'anChinaUnknown status
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ZhanjiangChinaUnknown status
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ZhengzhouChinaUnknown status
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ZhuhaiChinaUnknown status
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BrnoCzechiaUnknown status
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OlomoucCzechiaUnknown status
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Ostrava - VitkoviceCzechiaUnknown status
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PragueCzechiaUnknown status
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AachenGermanyUnknown status
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BerlinGermanyUnknown status
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GautingGermanyUnknown status
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GeraGermanyUnknown status
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HamburgGermanyUnknown status
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HeidelbergGermanyUnknown status
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MainzGermanyUnknown status
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RegensburgGermanyUnknown status
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A CoruñaSpainUnknown status
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BadajozSpainUnknown status
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BadalonaSpainUnknown status
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BarcelonaSpainUnknown status
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MadridSpainUnknown status
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SantanderSpainUnknown status
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ValenciaSpainUnknown status
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ZaragozaSpainUnknown status
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AvignonFranceUnknown status
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BrestFranceUnknown status
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CréteilFranceUnknown status
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La TroncheFranceUnknown status
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Pierre-BéniteFranceUnknown status
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RennesFranceUnknown status
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BudapestHungaryUnknown status
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DeszkHungaryUnknown status
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GyulaHungaryUnknown status
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KaposvárHungaryUnknown status
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KecskemétHungaryUnknown status
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MiskolcHungaryUnknown status
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PécsHungaryUnknown status
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SzékesfehérvárHungaryUnknown status
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JerusalemIsraelUnknown status
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Kfar SabaIsraelUnknown status
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Petah TikvaIsraelUnknown status
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Ramat GanIsraelUnknown status
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BergamoItalyUnknown status
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MeldolaItalyUnknown status
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MilanItalyUnknown status
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PalermoItalyUnknown status
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RomaItalyUnknown status
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TerniItalyUnknown status
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ChūōkuJapanUnknown status
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FukuokaJapanUnknown status
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FukushimaJapanUnknown status
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Himeji-shiJapanUnknown status
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Iwakuni-shiJapanUnknown status
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KashiwaJapanUnknown status
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KōtokuJapanUnknown status
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Kurume-shiJapanUnknown status
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KyotoJapanUnknown status
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MatsuyamaJapanUnknown status
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NagoyaJapanUnknown status
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OkayamaJapanUnknown status
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SakaishiJapanUnknown status
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SayamaJapanUnknown status
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TokushimaJapanUnknown status
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Ube-shiJapanUnknown status
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YokohamaJapanUnknown status
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ChangwonSouth KoreaUnknown status
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Cheongju-siSouth KoreaUnknown status
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DaeguSouth KoreaUnknown status
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IncheonSouth KoreaUnknown status
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JinjuSouth KoreaUnknown status
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Seongnam-siSouth KoreaUnknown status
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SeoulSouth KoreaUnknown status
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AmsterdamNetherlandsUnknown status
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ArnhemNetherlandsUnknown status
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GroningenNetherlandsUnknown status
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HengeloNetherlandsUnknown status
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MaastrichtNetherlandsUnknown status
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RotterdamNetherlandsUnknown status
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BialystokPolandUnknown status
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LublinPolandUnknown status
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OlsztynPolandUnknown status
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WarsawPolandUnknown status
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Cluj-NapocaRomaniaUnknown status
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FloreştiRomaniaUnknown status
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SuceavaRomaniaUnknown status
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MoscowRussiaUnknown status
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OmskRussiaUnknown status
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Rostov-on-DonRussiaUnknown status
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Saint PetersburgRussiaUnknown status
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UfaRussiaUnknown status
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Banská BystricaSlovakiaUnknown status
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BardejovSlovakiaUnknown status
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BratislavaSlovakiaUnknown status
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KošiceSlovakiaUnknown status
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Nové ZámkySlovakiaUnknown status
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TrnavaSlovakiaUnknown status
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ChanghuaTaiwanUnknown status
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Kaohsiung CityTaiwanUnknown status
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TaichungTaiwanUnknown status
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TainanTaiwanUnknown status
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TaipeiTaiwanUnknown status
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DniproUkraineUnknown status
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Ivano-FrankivskUkraineUnknown status
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KirovohradUkraineUnknown status
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Kryvyi RihUkraineUnknown status
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KyivUkraineUnknown status
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LvivUkraineUnknown status
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OdesaUkraineUnknown status
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SumyUkraineUnknown status
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VinnytsiaUkraineUnknown status
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ZaporizhzhyaUkraineUnknown status
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AthensUnited StatesUnknown status
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BirminghamUnited StatesUnknown status
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ClevelandUnited StatesUnknown status
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ColumbusUnited StatesUnknown status
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Fort WayneUnited StatesUnknown status
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Grand RapidsUnited StatesUnknown status
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HarrisburgUnited StatesUnknown status
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KennewickUnited StatesUnknown status
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LeawoodUnited StatesUnknown status
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MineolaUnited StatesUnknown status
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MuncieUnited StatesUnknown status
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NashvilleUnited StatesUnknown status
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New HavenUnited StatesUnknown status
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PaducahUnited StatesUnknown status
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RogersUnited StatesUnknown status
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Santa MonicaUnited StatesUnknown status
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ScottsdaleUnited StatesUnknown status
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Sioux FallsUnited StatesUnknown status
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WichitaUnited StatesUnknown status
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AnkaraTurkey (Türkiye)Unknown status
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EdirneTurkey (Türkiye)Unknown status
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IstanbulTurkey (Türkiye)Unknown status
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IzmirTurkey (Türkiye)Unknown status

This page is information, not medical advice. Discuss any trial with your doctor.