NCT03068442Active, not recruitingPhase 2
The Role of Large Artery Plaque Imaging Features in Predicting Inflammation and Cognition
Amyloid Deposition and Preexisting Vulnerable Carotid Plaque Features Predicting Cognitive Improvement After Surgery
Source: ClinicalTrials.gov · Last updated 13 May 2026
Brief summary (registry, in English)
The invesigators propose a clinical study on patients undergoing carotid surgery (endarterectomy). The invesigators will determine carotid artery imaging features associated with (1) vessel wall inflammation, (2) downstream brain inflammation, and (3) cognitive benefit from surgery. This project will uncover links between inflamed carotid plaque and downstream brain inflammation. The invesigators will also determine carotid plaque imaging features predicting cognitive benefit from carotid surgery.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 45 (estimated)
- First submitted
- 22 Feb 2017
- Start date
- 17 Feb 2017
- Primary completion date
- 10 Sept 2030
- Lead sponsor
- Scott Mcnally
- NCT number
- NCT03068442
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 45
- From 17 Feb 2017 to the primary completion date, 10 Sept 2030
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- \[18F\]Flutemetamol contraindications per manufacturer guidelines, including patients with prior reactions
Other illness
- Other known sources of cardioembolism, including atrial fibrillation, mechanical heart valve, left atrial or ventricular thrombus or intracardiac mass, endocarditis, EF \<30%
- Known stroke mimics including multiple sclerosis or brain tumor
- Known stage IV malignancy
Lab values
- MRI contraindications per ACR guidelines, including patients with pacemakers, renal failure with eGFR\<30 ml/min/1.73m2, and contrast allergy
Other
- Patients with carotid occlusion will be excluded, due to one carotid contributing to both right and left brain blood supply.
- Pregnancy
Who the study is looking for
- Patients ≥18 years old and plans for carotid endarterectomy.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| George E. Wahlen Department of Veterans Affairs Medical Center Coordinator of this site? Confirm its status | Salt Lake City | United States | Unknown status |
| University of Utah Coordinator of this site? Confirm its status | Salt Lake City | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.