NCT03079999Active, not recruitingPhase 2
Study of Aspirin in Patients With Vestibular Schwannoma
Prospective, Randomized, Placebo-Controlled Phase II Trial of Aspirin for Vestibular Schwannomas
Source: ClinicalTrials.gov · Last updated 16 Oct 2026
Brief summary (registry, in English)
This is a phase II prospective, randomized, double-blind, longitudinal study evaluating whether the administration of aspirin can delay or slow tumor growth and maintain or improve hearing in VS patients.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 97 (actual)
- First submitted
- 6 Mar 2017
- Start date
- 1 Mar 2018
- Primary completion date
- 31 Mar 2027
- Lead sponsor
- Massachusetts Eye and Ear Infirmary
- NCT number
- NCT03079999
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 97
- From 1 Mar 2018 to the primary completion date, 31 Mar 2027
- 5 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Known allergy to aspirin.
- Impairment of gastrointestinal function or gastrointestinal disease that may significantly alter the absorption of aspirin.
- Patients with serious medical illnesses (e.g. severe asthma) that in the option of the investigator could prevent participation in the trial.
- Active bleeding diathesis.
Age
- Febrile illness or flu-like illness in children and adolescents less than 18 years of age.
Other
- Inability to perform volumetric measurements of vestibular schwannoma(s).
- Inability to tolerate MRI with contrast.
- Daily use of aspirin within the last two months. Occasional use of aspirin for pain relief is not exclusionary.
- Pregnant or lactating women.
- Hydrocephalus from brainstem compression.
Who the study is looking for
- Radiographic diagnosis of vestibular schwannoma (NF2-associated or sporadic).
- Age≥12 years.
- Ability to provide informed consent.Pediatric patients must provide assent in addition to their parents'/guardians' consent. Adult patients who cannot consent for themselves will not be eligible to participate in this study.
- Ability to swallow tablets.
Age in the registry: 12 years to - · Sex: All · Does not accept healthy volunteers
Sites (5)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Massachusetts Eye and Ear Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| University of Miami Coordinator of this site? Confirm its status | Miami | United States | Unknown status |
| Mayo Clinic Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
| University of Utah Coordinator of this site? Confirm its status | Salt Lake City | United States | Unknown status |
| Stanford Otolaryngology/HNS Coordinator of this site? Confirm its status | Stanford | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.