NCT03081390Terminated
Migraine and CVD Risk in Women
Mechanisms of Increased Cardiovascular Disease Risk in Women With Migraine
Source: ClinicalTrials.gov · Last updated 6 Oct 2026
Reason given: Investigator transition
Brief summary (registry, in English)
The primary goal of this study is to test the effects of a high-fat, high-carbohydrate mixed meal on candidate modulators of cardiovascular disease risk (inflammation, vascular reactivity, sympathetic nervous system tone, and response to pain) in young adult women with migraine compared with healthy young women. This is study enrolling both cases (women with migraine) and controls (women without migraine), with equal numbers of normal weight and obese women in each group. Participants will undergo a telephone screening and a single day in-person study visit.
- Status (registry)
- Terminated
- Study type
- Interventional
- Enrollment
- 23 (actual)
- First submitted
- 16 Feb 2017
- Start date
- 1 Apr 2017
- Primary completion date
- 28 Sept 2026
- Lead sponsor
- University of Pennsylvania
- Diseases
- Migraine
- NCT number
- NCT03081390
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Chronic use of medications, including oral contraceptives
- Treatment with antibiotics or steroids within the previous 3 months
- Treatment with NSAIDs within the previous 1 week
Other illness
- Major medical or psychiatry illness (e.g. diabetes, fibromyalgia, major depression/anxiety)
- Allergies or sensitivity to any of the ingredients of the meal
Other
- Smoking (current or former)
- Pregnant or nursing
- Inability to fast for 10 hours and/or abstain from caffeine intake for 24 hours
- Migraine headaches, or headaches other than tension-type headaches with a frequency of 1 or fewer days per month
Who the study is looking for
- Female 18-35 years of age, inclusive
- BMI 18.5-24.9 kg/m2, inclusive
- BMI ≥30 kg/m2
- Diagnosis of migraine per ICHD-3-beta (1-10 migraine days per month)
Age in the registry: 18 years to 35 years · Sex: Female · Accepts healthy volunteers
Sites (2)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Pennsylvania | Philadelphia | United States | Unknown status |
| Children's Hospital of Philadelphia | Philadelphia | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.