NCT03089983Completed
Addiction, HIV and Tuberculosis in Malaysian Criminal Justice Settings
Source: ClinicalTrials.gov · Last updated 9 Feb 2026
Brief summary (registry, in English)
The purpose of this study is to conduct empiric studies of tuberculosis (TB) among people in prison with and without a history of opioid dependence. A RCT of latent TB infection prevention strategies among HIV+ and HIV- prisoners with high prevalence of hepatitis C (HCV) using standard 40-week daily isoniazid (40H) vs short-course weekly isoniazid + rifapentine (12HR). Investigators will also use this data, and publicly available data to complete agent-based modeling for comparative and cost-effectiveness of various TB screening and treatment strategies among prisoners.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 316 (actual)
- First submitted
- 16 Feb 2017
- Start date
- 21 Aug 2017
- Primary completion date
- 4 Apr 2024
- Lead sponsor
- Yale University
- Diseases
- Tuberculosis, HIV
- NCT number
- NCT03089983
What you commit to
- Study type: Interventional
- Participants enrolled: 316
- From 21 Aug 2017 to the primary completion date, 4 Apr 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- On a protease inhibitor
Other
- Unable to provide informed consent
- Women who are pregnant or are planning on becoming pregnant
Who the study is looking for
- Age ≥ 18 years
- Newly admitted inmate at Kajang Prison
- Age ≥ 18 years HIV-1 seropositivity
- Confirmed LTBI (TST ≥ 5mm if HIV+; TST ≥ 10 mm if HIV-)
- Meets DSM-V criteria for opioid dependence
- \>9 months before release (to ensure treatment completion in prison)
- AST/ALT \< 3x upper limit normal
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Kajang Prison Coordinator of this site? Confirm its status | Kajang | Malaysia | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.