NCT03102125RecruitingPhase 4
Allograft Dysfunction in Heart Transplant
Defining Mechanisms for Cardiac Allograft Dysfunction to Improve Allograft Longevity and Survival in Heart-Transplant Patients
Source: ClinicalTrials.gov · Last updated 1 May 2026
Brief summary (registry, in English)
The investigators will evaluate for early evidence of cardiac allograft dysfunction by cardiac MRI and single cell sequencing to determine underlying molecular and macroscopic causes.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 376 (estimated)
- First submitted
- 29 Mar 2017
- Start date
- 1 Oct 2019
- Primary completion date
- 1 Jan 2027
- Lead sponsor
- Paul Kim
- NCT number
- NCT03102125
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 376
- From 1 Oct 2019 to the primary completion date, 1 Jan 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior adverse reaction to either regadenoson or gadolinium contrast. Prior adverse reaction to adenosine or dipyridamole will be assessed on a case-by-case basis.
Other illness
- Patients with symptoms or signs of acute myocardial ischemia or recent acute coronary syndrome in the past 3 months.
- Uncontrolled obstructive ventilatory disease including asthma and COPD.
- History of generalized tonic-clonic seizures.
- Resting heart rate greater than 120 or less than 45 beats per minute. - Severe claustrophobia.
Lab values
- Renal dysfunction with an estimated GFR less than 30 mL/min/1.73m2.
Other
- Biopsy proven acute rejection episode in the past 3 months.
- Second or third degree AV nodal block.
- Sinus node dysfunction.
- Contraindications to MRI including cardiovascular implantable electronic devices.
- Systolic blood pressure greater than 180 or less than 85 mmHg.
- Diastolic blood pressure greater than 120 or less than 40 mmHg.
Who the study is looking for
- Age greater than or equal to 18 years old.
- At least three months status post heart transplantation.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| UC San Diego Coordinator of this site? Confirm its status | La Jolla | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.