Image Fusion of SPECT MPI and Fluoroscopy Venography to Guide LV Lead Placement for Improved CRT Response (GUIDE-CRT II)

Prior treatment

• Patient is on continuous or intermittent (i.e., more than two infusions per week) intravenous inotropic drug therapy
• Patient with CRT device implanted previously

Other illness

• Patient has mechanical right heart valve
• Patient has experienced unstable angina, acute MI, CABG or PCI within the past 3 months
• Patient known to have chronic permanent atrial arrhythmias (i.e., cases of long-standing atrial fibrillation of greater than 1 year, including those in which cardioversion has not been indicated or attempted).
• Patient has had a heart transplant
• Patient has third degree AVB with normal cardiac function

Age

• Patient is under a minimum age requirement (\<18 years old)

Other

• Patient is enrolled in any other study
• Patient has a life expectancy of less than 12 months
• Women who are pregnant, or with child-bearing potential and who are not on a form of birth control

• Patient has signed informed consent
• moderate to severe HF (NYHA Class II, III or IV)
• LVEF ≤35%
• QRS duration ≥130 ms
• sinus rhythm