NCT03165734Active, not recruitingPhase 3
A Phase 3 Study of Pacritinib in Patients With Primary Myelofibrosis, Post Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis
A Randomized, Controlled Phase 3 Study of Pacritinib Versus Physician's Choice in Patients With Primary Myelofibrosis, Post Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis With Severe Thrombocytopenia (Platelet Count <50,000/μL)(PACIFICA)
Source: ClinicalTrials.gov · Last updated 30 Apr 2026
Brief summary (registry, in English)
This study (study ID PAC203 North America; PAC303 ex-North America) is evaluating 200 mg BID of pacritinib compared to physician's choice (P/C) therapy in patients with MF and severe thrombocytopenia (platelet count \<50,000/μL). Approximately 399 patients in total will be enrolled, randomized 2:1 to either pacritinib (approximately 266 patients) or to P/C therapy (approximately 133 patients) Condition or disease: Primary Myelofibrosis/Post-Polycythemia Vera Myelofibrosis/ Post-essential Thrombocythemia Myelofibrosis Intervention/treatment: Drug-Pacritinib
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 407 (actual)
- First submitted
- 17 May 2017
- Start date
- 26 Jun 2017
- Primary completion date
- 5 Oct 2026
- Lead sponsor
- Swedish Orphan Biovitrum
- Diseases
- Myeloproliferative neoplasms
- NCT number
- NCT03165734
- EU CT number
- 2024-515953-52-00
- EudraCT number
- 2020-000111-69
What you commit to
- Study type: Interventional · Phase 3
- Participants enrolled: 407
- From 26 Jun 2017 to the primary completion date, 5 Oct 2026
- 193 sites in 24 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Completed allogeneic stem cell transplant or are eligible for and willing to complete other approved available therapy including allogeneic stem cell transplant
- Splenic irradiation within the last 6 months
- Previously treated with pacritinib
- Treatment with any MF-directed therapy within 14 days prior to treatment Day 1
- Prior treatment with more than one JAK2 inhibitor
- Prior treatment with with ruxolitinib, if BOTH of the following conditions are met:
- exposure to higher-dose ruxolitinib (\>10 mg daily) within 120 days prior to treatment Day 1 AND ii. total duration of treatment with higher-dose ruxolitinib (\>10 mg daily) was \>90 days, from first to last exposure (i.e., this 90-day period starts on the date of first administration of ruxolitinib at a total daily dose of \>10 mg and continues for 90 calendar days, regardless of whether higher-dose ruxolitinib is administered continuously or intermittently).
- Prior treatment with any JAK2 inhibitor other than ruxolitinib, irrespective of dose, with a duration of \>90 days. The 90-day period starts on the date of first administration of JAK2 inhibitor therapy and continues for 90 calendar days, regardless of whether therapy is administered continuously or intermittently.
- Treatment with an experimental therapy, including MF-directed experimental therapies within 28 days prior to treatment Day 1
- Systemic treatment with a strong cytochrome P450 3A4 (CYP 3A4) inhibitor or a strong CYP 3A4 inducer within 14 days prior to treatment Day 1. Shorter washout periods may be permitted with approval of the Medical Monitor, provided that the washout period is at least five half-lives of the drug prior to treatment Day 1
- Significant recent bleeding history defined as National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) grade ≥2 within 3 months prior to treatment Day 1, unless precipitated by an inciting event (eg, surgery, trauma, or injury)
- Systemic treatment with medications that increase the risk of bleeding, including anticoagulants, antiplatelet agents (except for aspirin dosages of ≤100 mg per day),and daily use of cyclooxygenase-1 (COX-1) inhibiting non-steroidal anti-inflammatory drugs (NSAIDs) within 14 days prior to treatment Day 1. Treatment with systemic anti-vascular endothelial growth factor (anti-VEGF) agents within 28 days prior to treatment Day 1.
- Any history of CTCAE grade ≥2 non-dysrhythmia cardiac conditions within 6 months prior to treatment Day 1. Patients with asymptomatic grade 2 non-dysrhythmia cardiovascular conditions may be considered for inclusion, with the approval of the Medical Monitor, if stable and unlikely to affect patient safety.
- Other malignancy within 3 years prior to treatment Day 1. The following patients may be eligible despite having had a malignancy within the prior 3 years: patients with curatively treated squamous or basal cell carcinoma of the skin; patients with curatively treated non-invasive cancers; patients with organ-confined prostate cancer with prostate specific antigen (PSA) \<20 ng/mL and National Comprehensive Cancer Network risk of Very Low, Low, or Favorable Intermediate; and patients with curatively treated non-metastatic prostate cancer with negative PSA.
- Concurrent enrollment in another interventional trial
Other illness
- History of splenectomy or planning to undergo splenectomy
- New York Heart Association Class II, III, or IV congestive heart failure
- Any active gastrointestinal or metabolic condition that could interfere with absorption of oral medication
- Active or uncontrolled inflammatory or chronic functional bowel disorder such as Crohn's Disease, inflammatory bowel disease, chronic diarrhea, or chronic constipation
- Uncontrolled intercurrent illness, including, but not limited to, ongoing active infection, psychiatric illness, or social situation that, in the judgment of the treating physician, would limit compliance with study requirements
- Known seropositivity for human immunodeficiency (HIV) virus. For patients in Czech Republic, France and Italy only: testing for HIV is required during Screening.
- Known active hepatitis A, B, or C virus infection. For patients in Czech Republic, France and Italy only: testing for hepatitis B and C is required during Screening.
- Severe thrombocytopenia due to vitamin B12 deficiency, folate deficiency, or viral infection in the opinion of the investigator
Lab values
- Systemic treatment with medications that can prolong the QT interval within 14 days prior to treatment Day 1. Shorter washout periods may be permitted with approval of the Medical Monitor, provided that the washout period is at least five half-lives of the drug prior to treatment Day 1
- Any history of CTCAE grade ≥2 cardiac dysrhythmias within 6 months prior to treatment Day 1. Patients with non-corrected QT interval CTCAE grade 2 cardiac dysrhythmias may be considered for inclusion, with the approval of the Medical Monitor, if the dysrhythmias are stable, asymptomatic, and unlikely to affect patient safety.
- QT corrected by the Fridericia method (QTcF) prolongation \>450 ms or other factors that increase the risk for QT interval prolongation (eg, hypokalemia \[defined as serum potassium \<3.0 mEq/L that is persistent and refractory to correction\], or history of long QT interval syndrome).
- Known hypersensitivity to pacritinib or any of the following inactive ingredients: microcrystalline cellulose, polyethylene glycol, and magnesium stearate; any contraindication to the "physician's choice" medicinal product selected by the investigator to be used as the comparator or to loperamide or equivalent antidiarrheal medication
Other
- Life expectancy \<6 months
- Women who are pregnant or lactating
- Persons deprived of their liberty by a judicial or administrative decision
- Persons subject to legal protection measures or unable to express their consent
- Temporarily incapacitated persons
Criteria the registry did not label
- Diagnosis and Inclusion Criteria
- Primary MF, post-polycythemia vera MF, or post-essential thrombocythemia MF (as defined by Tefferi and Vardiman 2008)
- Platelet count of \<50,000/μL at Screening (Day -35 to Day -3)
- Dynamic International Prognostic Scoring System Intermediate-1, Intermediate-2, or High-Risk (Passamonti et al 2010)
- Palpable splenomegaly ≥5 cm below the lower costal margin in the midclavicular line as assessed by physical examination
- TSS of ≥10 on the MPN-SAF TSS 2.0 or a single symptom score of ≥5 or two symptoms of ≥3, including only the symptoms of left upper quadrant pain, bone pain, itching, or night sweats. The TSS criteria need only to be met on a single day.
- Age ≥18 years
- Eastern Cooperative Oncology Group performance status 0 to 2
- Peripheral blast count of \<10% throughout the Screening period prior to randomization
- Absolute neutrophil count of ≥500/µL
- Left ventricular cardiac ejection fraction of ≥50% by echocardiogram or multigated acquisition scan
- Adequate liver and renal function, defined by liver transaminases (aspartate aminotransferase \[AST\]/serum glutamic-oxaloacetic transaminase \[SGOT\] and alanine aminotransferase \[ALT\]/serum glutamic pyruvic transaminase \[SGPT\]) ≤3 × the upper limit of normal (ULN) (AST/ALT ≤5 × ULN if transaminase elevation is related to MF), total bilirubin ≤4 x ULN (in cases where total bilirubin is elevated, direct bilirubin ≤4 × ULN, is required) and creatinine ≤2.5 mg/dL
- Adequate coagulation defined by prothrombin time/international normalized ratio and partial thromboplastin time ≤1.5 × ULN
- If fertile, willing to use highly effective birth control methods during the study (see Section 7.1.2.6 for acceptable birth control methods)
- Willing to undergo and able to tolerate frequent MRI or CT scan assessments during the study
- Able to understand and willing to complete symptom assessments using a patient-reported outcome instrument
- Provision of signed informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (193)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Alfred Hospital, Malignant Hematology and Stem Cell Transplantation Service Coordinator of this site? Confirm its status | Melbourne | Australia | Unknown status |
| The Perth Blood Institute Coordinator of this site? Confirm its status | Perth | Australia | Unknown status |
| Westmead Hospital Coordinator of this site? Confirm its status | Sydney | Australia | Unknown status |
| University Multiprofile Hospital for Active Treatment Dr Georgi Stranski EAD Coordinator of this site? Confirm its status | Pleven | Bulgaria | Active, not recruiting |
| University Multiprofile Hospital For Active Treatment Saint Georgi EAD Coordinator of this site? Confirm its status | Plovdiv | Bulgaria | Active, not recruiting |
| National Specialised Hospital For Active Treatment Of Haematological Diseases Coordinator of this site? Confirm its status | Sofia | Bulgaria | Active, not recruiting |
| Military Medical Academy Coordinator of this site? Confirm its status | Sofiya | Bulgaria | Active, not recruiting |
| Cetus Oncology Inc. Coordinator of this site? Confirm its status | Belo Horizonte | Brazil | Unknown status |
| State University of Campinas (UNICAMP) - Hemocenter Coordinator of this site? Confirm its status | Campinas | Brazil | Unknown status |
| Clinical Hospital of the Federal University of Parana (HC - UFPR) Coordinator of this site? Confirm its status | Curitiba | Brazil | Unknown status |
| Santa Catarina Health Research and Education Center (CEPEN) Coordinator of this site? Confirm its status | Florianópolis | Brazil | Unknown status |
| Integrare Therapeutics Coordinator of this site? Confirm its status | Fortaleza | Brazil | Unknown status |
| Clinics Hospital, Federal University of Goias - (UFG) Coordinator of this site? Confirm its status | Goiânia | Brazil | Unknown status |
| Hospital Amaral Carvalho Coordinator of this site? Confirm its status | Jaú | Brazil | Unknown status |
| Humane Clinic / Atena Research Institute Coordinator of this site? Confirm its status | Mossoró | Brazil | Unknown status |
| Hospital Moinhos de Vento Coordinator of this site? Confirm its status | Porto Alegre | Brazil | Unknown status |
| Integrated Oncology Center of Rio Grande do Sul - Mother of God Hospital Coordinator of this site? Confirm its status | Porto Alegre | Brazil | Unknown status |
| Saint Lucas Hospital of Copacabana Coordinator of this site? Confirm its status | Rio de Janeiro | Brazil | Unknown status |
| Hospital Sao Rafael Coordinator of this site? Confirm its status | Salvador | Brazil | Unknown status |
| Samaritano Hospital Coordinator of this site? Confirm its status | São Paulo | Brazil | Unknown status |
| Sao Paulo University Clinical Hospital Coordinator of this site? Confirm its status | São Paulo | Brazil | Unknown status |
| Jewish Hospital Albert Einstein Coordinator of this site? Confirm its status | São Paulo | Brazil | Unknown status |
| Grodno University Hospital Coordinator of this site? Confirm its status | Grodno | Belarus | Unknown status |
| Republican Research Center for Radiation Medicine and Human Ecology Coordinator of this site? Confirm its status | Homyel | Belarus | Unknown status |
| Minsk Scientific and Practical Center of Surgery, Transplantology and Hematology Coordinator of this site? Confirm its status | Minsk | Belarus | Unknown status |
| Tom Baker Cancer Center, Internal Medicine/Hematology Coordinator of this site? Confirm its status | Calgary | Canada | Unknown status |
| University of Alberta Coordinator of this site? Confirm its status | Edmonton | Canada | Unknown status |
| Nova Scotia Health Authority, Centre for Clinical Research Coordinator of this site? Confirm its status | Halifax | Canada | Unknown status |
| Jewish General Hospital; Clinical Research Unit Coordinator of this site? Confirm its status | Montreal | Canada | Unknown status |
| Eastern Regional Health Authority Coordinator of this site? Confirm its status | St. John's | Canada | Unknown status |
| Princess Margaret Cancer Centre Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| Providence Hematology - Vancouver Coordinator of this site? Confirm its status | Vancouver | Canada | Unknown status |
| Fakultni nemocnice Brno Coordinator of this site? Confirm its status | Brno | Czechia | Active, not recruiting |
| University Hospital Olomouc Coordinator of this site? Confirm its status | Olomouc | Czechia | Active, not recruiting |
| Fakultni Nemocnice Plzen Coordinator of this site? Confirm its status | Plzen 23 | Czechia | Active, not recruiting |
| Fakultni nemocnice Kralovske Vinohrady Coordinator of this site? Confirm its status | Prague | Czechia | Active, not recruiting |
| Hospital Clinic de Barcelona Coordinator of this site? Confirm its status | Barcelona | Spain | Active, not recruiting |
| Hospital Universitario Ramón y Cajal Coordinator of this site? Confirm its status | Madrid | Spain | Active, not recruiting |
| Hospital Universitario 12 de Octubre Coordinator of this site? Confirm its status | Madrid | Spain | Active, not recruiting |
| Hospital General Universitario Morales Meseguer Coordinator of this site? Confirm its status | Murcia | Spain | Active, not recruiting |
| Hospital Universitario De Salamanca Coordinator of this site? Confirm its status | Salamanca | Spain | Active, not recruiting |
| University Hospital Virgen Del Rocio S.L. Coordinator of this site? Confirm its status | Sevilla | Spain | Active, not recruiting |
| Centre hospitalier Universitaire de Bordeaux Coordinator of this site? Confirm its status | Bordeaux | France | Active, not recruiting |
| Centre Hospitalier Universitaire De Nimes Coordinator of this site? Confirm its status | Nimes Cedex 9 | France | Active, not recruiting |
| Assistance Publique Hopitaux de Paris Coordinator of this site? Confirm its status | Paris | France | Active, not recruiting |
| Hospices Civils de Lyon Coordinator of this site? Confirm its status | Pierre-Bénite | France | Active, not recruiting |
| Centre Hospitalier Universitaire de Poitiers Coordinator of this site? Confirm its status | Poitiers | France | Active, not recruiting |
| Beatson West of Scotland Cancer Centre Coordinator of this site? Confirm its status | Glasgow | United Kingdom | Unknown status |
| Gloucestershire Royal Hospital Coordinator of this site? Confirm its status | Gloucester | United Kingdom | Unknown status |
| Guy's and St Thomas' NHS Foundation Trust - Guy's Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| Barts Health NHS Trust , The Royal London Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| Imperial College Healthcare Nhs Trust - Hammersmith Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| Oxford University Hospitals NHS Trust - Churchill Hospital Coordinator of this site? Confirm its status | Oxford | United Kingdom | Unknown status |
| Royal Hallamshire Hospital, Department of Hematology Coordinator of this site? Confirm its status | Sheffield | United Kingdom | Unknown status |
| JSC K. Eristavi National Center For Experimental and Clinical Surgery Coordinator of this site? Confirm its status | Tbilisi | Georgia | Unknown status |
| Malkhaz Katsiashvili Multiprofile Emergency Medicine Center LTD Coordinator of this site? Confirm its status | Tbilisi | Georgia | Unknown status |
| LTD M.Zodelava's Hematology Center, Department of Hematology Coordinator of this site? Confirm its status | Tbilisi | Georgia | Unknown status |
| Tbilisi State Medical University and Ingorokva High Medical Technology University Clinic LLC Coordinator of this site? Confirm its status | Tbilisi | Georgia | Unknown status |
| LTD S.Khechinashvili University Hospital Coordinator of this site? Confirm its status | Tbilisi | Georgia | Unknown status |
| Somogy Vármegyei Kaposi Mór Oktató Kórház Coordinator of this site? Confirm its status | Kaposvár | Hungary | Completed |
| Fejer Varmegyei Szent Gyoergy Egyetemi Oktato Korhaz Coordinator of this site? Confirm its status | Szekesfehervar | Hungary | Completed |
| Lady Davis Carmel Medical Center, Department of Hematology, Coordinator of this site? Confirm its status | Haifa | Israel | Unknown status |
| Hadassah Medical Center, Department of Hematology Coordinator of this site? Confirm its status | Jerusalem | Israel | Unknown status |
| Meir Medical Center, Hematology Institute and Blood Bank Coordinator of this site? Confirm its status | Kfar Saba | Israel | Unknown status |
| Rabin Medical Center, Clinic for Myeloproliferative Disorders Coordinator of this site? Confirm its status | Petah Tikva | Israel | Unknown status |
| The Tel Aviv Sourasky Medical Center, Department of Internal Medicine Coordinator of this site? Confirm its status | Tel Aviv | Israel | Unknown status |
| St. John's Medical College Hospital Coordinator of this site? Confirm its status | Bengaluru | India | Unknown status |
| Postgraduate Institute of Medical Education and Research (PGIMER) Coordinator of this site? Confirm its status | Chandigarh | India | Unknown status |
| All India Institute of Medical Sciences Coordinator of this site? Confirm its status | Dehradun | India | Unknown status |
| Max Super Speciality Hospital Saket (A Unit of Max Healthcare Institute Limited) Coordinator of this site? Confirm its status | Delhi | India | Unknown status |
| Fortis Memorial Research Institute(FMRI) Coordinator of this site? Confirm its status | Gurgaon | India | Unknown status |
| Gauhati Medical college and Hospital Coordinator of this site? Confirm its status | Guwahati | India | Unknown status |
| Yashoda Hospitals Coordinator of this site? Confirm its status | Hyderabad | India | Unknown status |
| Shri Ram Cancer Centre, Mahatma Gandhi Medical College & Hospital Coordinator of this site? Confirm its status | Jaipur | India | Unknown status |
| Tata Medical Center Coordinator of this site? Confirm its status | Kolkata | India | Unknown status |
| Netaji Subhash Chandra Bose Cancer Research Institute Coordinator of this site? Confirm its status | Kolkata | India | Unknown status |
| Meenakshi Mission Hospital And Research Centre (MMHRC) Coordinator of this site? Confirm its status | Madurai | India | Unknown status |
| Sahyadri Super Speciality Hospital Coordinator of this site? Confirm its status | Pune | India | Unknown status |
| Nirmal Hospital Pvt Ltd. Coordinator of this site? Confirm its status | Surat | India | Unknown status |
| Istituto Tumori Bari Giovanni Paolo II Coordinator of this site? Confirm its status | Bari | Italy | Active, not recruiting |
| Azienda Ospedaliero-Universitaria Di Bologna IRCCS Istituto Di Ricerca E Di Cura A Carattere Scientifico Coordinator of this site? Confirm its status | Bologna | Italy | Active, not recruiting |
| Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia Coordinator of this site? Confirm its status | Brescia | Italy | Active, not recruiting |
| Careggi University Hospital Coordinator of this site? Confirm its status | Florence | Italy | Active, not recruiting |
| Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST S.r.l Coordinator of this site? Confirm its status | Meldola | Italy | Active, not recruiting |
| Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico Coordinator of this site? Confirm its status | Milan | Italy | Active, not recruiting |
| Fondazione IRCCS San Gerardo dei Tintori Coordinator of this site? Confirm its status | Monza | Italy | Active, not recruiting |
| Azienda Ospedaliera Universitaria Federico II Di Napoli Coordinator of this site? Confirm its status | Naples | Italy | Active, not recruiting |
| Azienda Ospedaliero Universitaria Maggiore della Carità Coordinator of this site? Confirm its status | Novara | Italy | Active, not recruiting |
| Azienda Ospedaliera Ospedali Riuniti Villa Sofia - Cervello Coordinator of this site? Confirm its status | Palermo | Italy | Active, not recruiting |
| Azienda Ospedaliero-Universitaria Policlinico Umberto I Coordinator of this site? Confirm its status | Rome | Italy | Active, not recruiting |
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS Coordinator of this site? Confirm its status | Rome | Italy | Active, not recruiting |
| Azienda Ospedaliera Universitaria Citta Della Salute E Della Scienza Di Torino Coordinator of this site? Confirm its status | Turin | Italy | Active, not recruiting |
| Azienda Sanitaria Universitaria Friuli Centrale Coordinator of this site? Confirm its status | Udine | Italy | Active, not recruiting |
| Azienda Socio Sanitaria Territoriale Dei Sette Laghi Coordinator of this site? Confirm its status | Varese | Italy | Active, not recruiting |
| University of Yamanashi Hospital Coordinator of this site? Confirm its status | Chūō | Japan | Unknown status |
| Kyushu University Hospital Coordinator of this site? Confirm its status | Fukuoka | Japan | Unknown status |
| Fukushima Medical University Hospital Coordinator of this site? Confirm its status | Fukushima | Japan | Unknown status |
| Tohoku University Hospital Coordinator of this site? Confirm its status | Miyagi | Japan | Unknown status |
| University of Miyazaki Hospital Coordinator of this site? Confirm its status | Miyazaki | Japan | Unknown status |
| Tokyo Medical University Hospital Coordinator of this site? Confirm its status | Tokyo | Japan | Unknown status |
| Juntendo University Hospital Coordinator of this site? Confirm its status | Tokyo | Japan | Unknown status |
| Nippon Medical School Hospital Coordinator of this site? Confirm its status | Tokyo | Japan | Unknown status |
| Ehime University Hospital Coordinator of this site? Confirm its status | Tōon | Japan | Unknown status |
| Mie University Hospital Coordinator of this site? Confirm its status | Tsu | Japan | Unknown status |
| Pusan National University Hospital Coordinator of this site? Confirm its status | Busan | South Korea | Unknown status |
| Kyungpook National University Hospital Coordinator of this site? Confirm its status | Daegu | South Korea | Unknown status |
| Samsung Medical Center Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
| Seoul National University Hospital Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
| Severance hospital Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
| The Catholic University of Korea, St. Mary's Hospital Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
| Aktobe Medical Center, Department of Hematology Coordinator of this site? Confirm its status | Aktobe | Kazakhstan | Unknown status |
| City Clinical Hospital #7, Hematology Department Coordinator of this site? Confirm its status | Almaty | Kazakhstan | Unknown status |
| Center for Hematology Coordinator of this site? Confirm its status | Astana | Kazakhstan | Unknown status |
| National Research Oncology, Oncohematology Center Coordinator of this site? Confirm its status | Astana | Kazakhstan | Unknown status |
| Hematology Center Coordinator of this site? Confirm its status | Karaganda | Kazakhstan | Unknown status |
| City Oncological Center Coordinator of this site? Confirm its status | Shymkent | Kazakhstan | Unknown status |
| Center for Hematology Coordinator of this site? Confirm its status | Ust-Kamenogorsk | Kazakhstan | Unknown status |
| Uniwersytecki Szpital Kliniczny w Bialymstoku Coordinator of this site? Confirm its status | Bialystok | Poland | Active, not recruiting |
| Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki W Krakowie Coordinator of this site? Confirm its status | Cracow | Poland | Active, not recruiting |
| Uniwersyteckie Centrum Kliniczne Coordinator of this site? Confirm its status | Gdansk | Poland | Active, not recruiting |
| Pratia Hematologia Sp. Z o. o Coordinator of this site? Confirm its status | Katowice | Poland | Active, not recruiting |
| Samodzielny Publiczny Szpital Kliniczny Im.Andrzeja Mieleckiego Slaskiego Uniwersytetu Medycznego W Katowicach Coordinator of this site? Confirm its status | Katowice | Poland | Active, not recruiting |
| Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi Coordinator of this site? Confirm its status | Lodz | Poland | Active, not recruiting |
| Uniwersytecki Szpital Kliniczny Nr 1 w Lublinie Coordinator of this site? Confirm its status | Lublin | Poland | Active, not recruiting |
| Szpital Specjalistyczny Im. Jedrzeja Sniadeckiego W Nowym Saczu SPZOZ Coordinator of this site? Confirm its status | Nowy Sacz | Poland | Active, not recruiting |
| Uniwersytecki Szpital Kliniczny im Jana Mikulicza Radeckiego we Wroclawiu Coordinator of this site? Confirm its status | Wroclaw | Poland | Active, not recruiting |
| Onco Card S.R.L. Coordinator of this site? Confirm its status | Brasov | Romania | Active, not recruiting |
| Spitalul Clinic Colțea Coordinator of this site? Confirm its status | Bucharest | Romania | Active, not recruiting |
| Institutul Clinic Fundeni Coordinator of this site? Confirm its status | Bucharest | Romania | Active, not recruiting |
| Institute Of Oncology Prof. Dr. Ion Chiricuta Cluj-Napoca Coordinator of this site? Confirm its status | Cluj-Napoca | Romania | Active, not recruiting |
| Clinical Center of Serbia, Clinic of Hematology Coordinator of this site? Confirm its status | Belgrade | Serbia | Unknown status |
| Clinical Center of Vojvodina, Clinic of Hematology Coordinator of this site? Confirm its status | Novi Sad | Serbia | Unknown status |
| S.P. Botkin City Clinical Hospital Coordinator of this site? Confirm its status | Moscow | Russia | Unknown status |
| City Clinical Hospital n.a. V.V. Veresaev of the Moscow City Health Coordinator of this site? Confirm its status | Moscow | Russia | Unknown status |
| City Clinical Hospital # 40 Coordinator of this site? Confirm its status | Moscow | Russia | Unknown status |
| Clinic UZI 4D, LLC Coordinator of this site? Confirm its status | Pyatigorsk | Russia | Unknown status |
| Research Institute of Hematology and Transfusiology Coordinator of this site? Confirm its status | Saint Petersburg | Russia | Unknown status |
| S.M. Kirov Military Medical Academy, Department and Clinic for Intermediate-Level Training in Internal Medicine, Hematology Division Coordinator of this site? Confirm its status | Saint Petersburg | Russia | Unknown status |
| V.A. Almazov North-West Federal Medical Research Center, Institute of Oncology and Hematology, Scientific Department of Clinical Oncology Coordinator of this site? Confirm its status | Saint Petersburg | Russia | Unknown status |
| Bashkiria State Medical University, Department of Internal Medicine Coordinator of this site? Confirm its status | Ufa | Russia | Unknown status |
| Volgograd Regional Clinical Oncology Center Coordinator of this site? Confirm its status | Volgograd | Russia | Unknown status |
| Cherkasy Regional Oncology Dispensary of Cherkasy Oblast Council, Regional Treatment and Diagnostic Hematology Center, Department of Hematology Coordinator of this site? Confirm its status | Cherkasy | Ukraine | Unknown status |
| City Clinical Hospital #4" under Dnipro City Council Coordinator of this site? Confirm its status | Dnipro | Ukraine | Unknown status |
| Communal Non-profit Enterprise Regional Center of Oncology, Department of Hematology Coordinator of this site? Confirm its status | Kharkiv | Ukraine | Unknown status |
| Kyiv Regional Oncology Center, Department of Hematology, Coordinator of this site? Confirm its status | Kyiv | Ukraine | Unknown status |
| Limited Liability Company "City Doctor" Coordinator of this site? Confirm its status | Kyiv | Ukraine | Unknown status |
| Kyiv City Clinical Hospital #9, Hematology Department #1 Coordinator of this site? Confirm its status | Kyiv | Ukraine | Unknown status |
| Institute of Blood Pathology and Transfusion Medicine, Department of Hematology Coordinator of this site? Confirm its status | Lviv | Ukraine | Unknown status |
| Poltava M.V. Sklifosovskyi Regional Clinical Hospital under Poltava Regional Council, Department of Hematology Coordinator of this site? Confirm its status | Poltava | Ukraine | Unknown status |
| Michigan Medicine Hematology Clinic-Rogel Cancer Center Coordinator of this site? Confirm its status | Ann Arbor | United States | Unknown status |
| University of Colorado Cancer Center Coordinator of this site? Confirm its status | Aurora | United States | Unknown status |
| Johns Hopkins University Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| Saint Agnes Hospital Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| American Oncology Partners of Maryland, PA Coordinator of this site? Confirm its status | Bethesda | United States | Unknown status |
| Regional Cancer Care Associates LLC - CCBD Division Coordinator of this site? Confirm its status | Bethesda | United States | Unknown status |
| University of Alabama at Birmingham, (UAB) Hospital, Comprehensive Cancer Center Coordinator of this site? Confirm its status | Birmingham | United States | Unknown status |
| Rocky Mountain Cancer Centers (US Oncology/McKesson) Coordinator of this site? Confirm its status | Boulder | United States | Unknown status |
| Rush University Medical Center Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| Northwestern Memorial Hospital Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| The University of Chicago Medical Center Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| Cleveland Clinic Coordinator of this site? Confirm its status | Cleveland | United States | Unknown status |
| Maryland Oncology Hematology, PA- Columbia Coordinator of this site? Confirm its status | Columbia | United States | Unknown status |
| The James Cancer Hospital and Solove Research Institute Coordinator of this site? Confirm its status | Columbus | United States | Unknown status |
| City of Hope Coordinator of this site? Confirm its status | Duarte | United States | Unknown status |
| Duke University Hospital Coordinator of this site? Confirm its status | Durham | United States | Unknown status |
| Cancer and Hematology Centers of Western Michigan Coordinator of this site? Confirm its status | Grand Rapids | United States | Unknown status |
| Hackensack University Medical Center Coordinator of this site? Confirm its status | Hackensack | United States | Unknown status |
| The University of Texas MD Anderson Cancer Center Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| Comprehensive Cancer Centers of Nevada - Twain Office Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| USC / Norris Comprehensive Cancer Center Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| UCLA David Geffen School of Medicine Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| The Sarah Cannon Research Institute/Tennessee Oncology Coordinator of this site? Confirm its status | Nashville | United States | Unknown status |
| Yale School of Medicine Coordinator of this site? Confirm its status | New Haven | United States | Unknown status |
| Ochsner Medical Center Coordinator of this site? Confirm its status | New Orleans | United States | Unknown status |
| Memorial Sloan-Kettering Cancer Center Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Icahn School of Medicine at Mount Sinai Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Columbia University Medical Center Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Weill Cornell Medical College Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Mayo Clinic Hospital Coordinator of this site? Confirm its status | Phoenix | United States | Unknown status |
| UPMC Hillman Cancer Center Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
| Oregon Health and Science University Coordinator of this site? Confirm its status | Portland | United States | Unknown status |
| University of Rochester Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
| University of Utah - Huntsman Cancer Institute Coordinator of this site? Confirm its status | Salt Lake City | United States | Unknown status |
| Mays Cancer Center Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| Texas Oncology - San Antonio Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| Fred Hutchinson Cancer Research Center Coordinator of this site? Confirm its status | Seattle | United States | Unknown status |
| Washington University School of Medicine - Siteman Cancer Center Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Georgetown University Hospital Coordinator of this site? Confirm its status | Washington D.C. | United States | Unknown status |
| George Washington University- Medical Faculty Associates Coordinator of this site? Confirm its status | Washington D.C. | United States | Unknown status |
| Cleveland Clinic Florida Coordinator of this site? Confirm its status | Weston | United States | Unknown status |
| University of Kansas Cancer Center and Medical Pavilion Coordinator of this site? Confirm its status | Westwood | United States | Unknown status |
| University Clinical Centre of the Republic of Srpska Coordinator of this site? Confirm its status | Banja Luka | Bosnia and Herzegovina | Unknown status |
| University Clinical Center of Sarajevo Coordinator of this site? Confirm its status | Sarajevo | Bosnia and Herzegovina | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.