NCT03198494Active, not recruiting
Acoustic Stimulation for Seizure Suppression
Low Frequency Acoustic Stimulation During Sleep for Seizure Suppression
Source: ClinicalTrials.gov · Last updated 27 Feb 2026
Brief summary (registry, in English)
The objective of this study is to test the feasibility and physiological effect of low-frequency (1 Hz) acoustic stimulation delivered during nocturnal NREM sleep in epilepsy patients. The long-term goal is to develop this protocol for daily, long-term use in a home setting, for nocturnal seizure and IED suppression
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 36 (estimated)
- First submitted
- 16 Jun 2017
- Start date
- 17 Aug 2017
- Primary completion date
- 21 Nov 2028
- Lead sponsor
- NYU Langone Health
- Diseases
- Epilepsy
- NCT number
- NCT03198494
What you commit to
- Study type: Interventional
- Planned participants: 36
- From 17 Aug 2017 to the primary completion date, 21 Nov 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Psychoactive medication use (other than AEDs, for example SSRIs, antipsychotics, BDZ, or stimulants)
- Seizures ≤ 24 hours prior to study.
- Alcohol or recreational drug use in the 24 hours prior to the study
- History of recent travel across time zones within the 1 month prior to study activities
- Shift work for 1 month prior to study activities Additional Exclusion Criteria for Aim 3
- No medication changes at least 1 month before study, and during 3 months of study activities
Other illness
- Hearing impairment
- Diagnosis of a sleep disorder (sleep apnea, periodic limb movements of sleep, or other medical conditions with frequent arousals)
Other
- BMI ≥ 30
- MOCA \<26
Who the study is looking for
- 18-60 years old
- Able to provide informed consent
- MOCA ≥26
- Fluent in English
- Frequent nocturnal IEDs (≥ 10% of the sleep record)
- Monitored on the adult epilepsy monitoring unit (EMU, for Aim 1 only) Additional inclusion criteria for Aim 3
- Frequent nocturnal seizures (≥1 per week)
Age in the registry: 18 years to 60 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| New York University School of Medicine Coordinator of this site? Confirm its status | New York | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.