NCT03203603Completed
VCSIP Follow-up Study
Vitamin C to Decrease the Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP): Follow-up of a Randomized Trial
Source: ClinicalTrials.gov · Last updated 25 Mar 2025
Brief summary (registry, in English)
The overall aims of this protocol are to determine whether prenatal supplementation with vitamin C to pregnant smokers can improve pulmonary function and decrease wheeze at 5 years of age in their offspring. This is a continuation of the VCSIP trial, to follow the offspring through 5 years of age. The hypothesis for this protocol is an extension of the VCSIP trial that supplemental vitamin C in pregnant smokers can significantly improve their children's PFTs and decrease the incidence of wheeze.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 242 (actual)
- First submitted
- 28 Mar 2017
- Start date
- 27 Mar 2017
- Primary completion date
- 31 Dec 2021
- Lead sponsor
- Oregon Health and Science University
- Diseases
- Asthma
- NCT number
- NCT03203603
What you commit to
- Study type: Observational
- Participants enrolled: 242
- From 27 Mar 2017 to the primary completion date, 31 Dec 2021
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Patients specifically withdrawing consent.
Who the study is looking for
- Women and their offspring randomized to vitamin C versus placebo during pregnancy as well as pregnant nonsmokers and their offspring enrolled as the reference group in the current RCT.
Age in the registry: 6 months to 4 years · Sex: All
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Indiana University Coordinator of this site? Confirm its status | Indianapolis | United States | Unknown status |
| Oregon Health and Science University Coordinator of this site? Confirm its status | Portland | United States | Unknown status |
Related publications
- Vitamin C supplementation to pregnant smokers alters asthma- and allergy-associated CpGs in child buccal DNA at 5 years of age.Clin Epigenetics · 2025 · PMID 41044653
This page is information, not medical advice. Discuss any trial with your doctor.