Improving Hypertension Control in CHina and ARGEntina With a Mobile APP-based Telecare System

Other illness

• Severe uncontrolled hypertension (i.e. BP ≥200/120 mmHg despite treatment);
• Known secondary hypertension;
• Unstable clinical conditions or severe disease with short life expectation;
• History of gastrointestinal surgery or disorders which could interfere with drug absorption
• History of malignancy including leukaemia and lymphoma (but not basal cell skin cancer) within the last 5 years;
• History of clinically significant autoimmune disorders such as systemic lupus erythematosus;
• History of drug or alcohol abuse within the last 5 years;
• History of non-compliance to medical regimens and/or patients who are considered potentially unreliable;
• Dementia (clinical diagnosis);

Lab values

• eGFR \<45 mL/min/1.73 m2 (CKD-EPI creatinine equation 2009);
• Hepatic disease as determined by either AST or ALT values \> 2 times the upper limit of normal;

Other

• Orthostatic hypotension (SBP fall \> 20 mmHg on standing);
• Known atrial fibrillation;
• Inability or unwillingness to give free informed consent;
• Inability to use even simple communication technologies;
• Pregnancy or planned pregnancy during study period

• Male and female subjects;
• Age 18-80 years;
• Either the patient or another person close to him/her should possess a smartphone compatible with the ESH CARE app and be capable of using it;
• Uncontrolled (untreated or treated) hypertension, defined as office BP ≥140/90 mmHg, and Ambulatory 24h ABP ≥130/80 mmHg