NCT03228537Active, not recruitingPhase 1
Atezolizumab, Pemetrexed Disodium, Cisplatin, and Surgery With or Without Radiation Therapy in Treating Patients With Stage I-III Pleural Malignant Mesothelioma
A Feasibility Trial of Neoadjuvant Cisplatin-Pemetrexed With Atezolizumab in Combination and in Maintenance for Resectable Malignant Pleural Mesothelioma
Source: ClinicalTrials.gov · Last updated 22 Oct 2026
Brief summary (registry, in English)
This phase I pilot trial studies how well atezolizumab, pemetrexed disodium, cisplatin, and surgery with or without radiation therapy works in treating patients with stage I-III pleural malignant mesothelioma. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Pemetrexed disodium may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving atezolizumab, pemetrexed disodium, and cisplatin before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. Giving atezolizumab after surgery may kill any remaining tumor cells.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 28 (actual)
- First submitted
- 24 Jul 2017
- Start date
- 16 Jul 2018
- Primary completion date
- 1 Oct 2022
- Lead sponsor
- National Cancer Institute (NCI)
- Diseases
- Mesothelioma, Lung cancer
- NCT number
- NCT03228537
What you commit to
- Study type: Interventional · Phase 1
- Participants enrolled: 28
- From 16 Jul 2018 to the primary completion date, 1 Oct 2022
- 174 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Who the study is looking for
- STEP 1: NEOADJUVANT
- Patient must have stage I-III malignant pleural mesothelioma that is deemed resectable and must be planning to undergo pleurectomy decortication (P/D) or extrapleural pneumonectomy (EPP)
- Patient must have epithelioid or biphasic histology (sarcomatoid histology is excluded); histologic diagnosis and typing of mesothelioma requires at least a core needle biopsy or surgical biopsy of the pleura via thoracoscopy and small thoracotomy; cytology only will not be regarded as sufficient for the diagnosis
- Patient must have computed tomography (CT) chest/abdomen/pelvis with contrast or fludeoxyglucose F-18 (FDG)-positron emission tomography (PET)/CT scan performed within 28 days prior to step 1 registration
- Patients must have non-measurable or measurable disease documented by CT or magnetic resonance imaging (MRI); the CT from a combined PET/CT may be used to document only non-measurable disease unless it is of diagnostic quality; measurable disease must be assessed within 28 days prior to step 1 registration; non-measurable disease must be assessed within 42 days prior to step 1 registration; all disease must be assessed and documented on the RECIST 1.1 and modified RECIST baseline tumor assessment form
- Patient must have undergone extended surgical staging including mediastinoscopy or endobronchial ultrasound; at minimum, samples must be obtained from the mediastinal stations 4R, 7 (subcarinal), and 4L; this surgical staging must be performed within 42 days prior to step 1 registration; patient must be T1-3 and N0-N2 (single station)
- Patient must undergo video-assisted thoracoscopic surgery and diagnostic laparoscopy within 28 days prior to step 1 registration to rule out peritoneal disease spread
- Patient must have consultation with a surgeon within 21 days prior to step 1 registration; the surgeon must confirm that the patient's disease is resectable by pleurectomy decortication (P/D) or extrapleural pneumonectomy (EPP) and that the patient is an appropriate candidate for the surgical procedures
- Patient must not have had prior immunotherapy or chemotherapy for malignant pleural mesothelioma
- Patient must have Zubrod performance status 0 or 1 documented within 28 days prior to step 1 registration
- Patients requiring hearing aids or reporting hearing loss must have audiogram performed within 28 days prior to step 1 registration
- Patient must have not had any major surgery or radiation within 28 days prior to step 1 registration; diagnostic thoracotomies and laparoscopies are not considered major surgeries
- Patients must not have any anticancer therapy or investigational agent within 28 days prior to step 1 registration
- Absolute neutrophil count (ANC) \>= 1,500/mcl (documented within 28 days prior to step 1 registration)
- Hemoglobin \>= 9 g/dl (documented within 28 days prior to step 1 registration)
- Platelets \>= 100,000/mcl (documented within 28 days prior to step 1 registration)
- Creatinine =\< 1.5 x upper limit of normal (ULN) (documented within 28 days prior to step 1 registration)
- Creatinine clearance \>= 45 ml/min (documented within 28 days prior to step 1 registration)
- Total bilirubin =\< 1.5 x upper limit of normal (ULN) (within 28 days prior to step 1 registration)
- Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =\< 3 x ULN (within 28 days prior to step 1 registration)
- No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for three years
- Patients must not be pregnant or nursing due to the potential teratogenic side effects of the protocol treatment; women of reproductive potential and men must have agreed to use an effective contraceptive method for the duration of study treatment and for 5 months (150 days) after the last dose of atezolizumab; a woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months; in addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation; however, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures
- Patient must NOT have a history of severe allergic, anaphylactic, or other hypersensitivity reactions to chimeric or humanized antibodies or fusion proteins
- Patient must NOT have a known hypersensitivity or allergy to biopharmaceuticals produced in Chinese hamster ovary cells or any component of the atezolizumab formulation
- Patients must not have severe infections within 28 days prior to step 1 registration, including but not limited to hospitalization for complications of infection, bacteremia, or severe pneumonia
- Patients must not have active autoimmune disease that has required systemic treatment in past two years (i.e., with use of disease modifying agents, corticosteroids or immunosuppressive drugs); replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment; autoimmune diseases include, but are not limited to, systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, vascular thrombosis associated with antiphospholipid syndrome, Wegener's granulomatosis, Sjogren's syndrome, Bell's palsy, Guillain-Barre syndrome, multiple sclerosis, autoimmune thyroid disease, vasculitis, or glomerulonephritis; this protocol includes an immunotherapy agent which can precipitate known autoimmune diseases
- Patients must not have undergone prior allogeneic bone marrow transplantation or prior solid organ transplantation
- Patient must not have active tuberculosis
- Patient must not have history of idiopathic pulmonary fibrosis, pneumonitis (including drug induced), organizing pneumonia (i.e., bronchiolitis obliterans, cryptogenic organizing pneumonia, etc.), or evidence of active pneumonitis; this protocol includes an immunotherapy agent which can precipitate known pneumonitis
- Patient must not have active (chronic or acute) hepatitis B virus (HBV) infection as evidenced by testing performed within 28 days prior to registration; patients with past or resolved HBV infection are eligible; active HBV is defined as having a positive hepatitis B surface antigen (HBsAg) test; past or resolved HBV is defined as having a negative HBsAG test and a positive total hepatitis B core antibody (HBcAb) test; patient must not have active hepatitis C virus (HCV) infection as evidenced by testing performed within 28 days prior to registration; active HCV is defined as having a positive HCV antibody test followed by a positive HCV RNA test
- Patient must NOT have a known positive test for human immunodeficiency virus (HIV); patients do not need to be screened for HIV; patients with HIV are excluded due to a potential incompetent immune system and need for medications that could interfere with the treatment and immunotherapy
- Patient must not have significant cardiovascular disease, such as New York Heart Association cardiac disease (class II or greater), myocardial infarction within 3 months prior to initiation of treatment, unstable arrhythmias, or unstable angina given the higher risks associated with surgical resection
- Patient must not receive live, attenuated influenza vaccine within 4 weeks prior to registration or at any time during the study and until 5 months after the last dose of atezolizumab
- Patient must be willing to have tissue specimens submitted for translational medicine studies
- Patient must be offered the opportunity to participate in tissue and blood banking for future studies
- Patient must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines
- As a part of the Oncology Patient Enrollment Network (OPEN) registration process, the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system
- STEP 2: SURGERY
- Patient must have a CT of chest/abdomen with contrast or FDG-PET/CT scan within 28 days prior to step 2 registration; patients must not have evidence of progression per RECIST 1.1 or modified RECIST for pleural tumors
- Patients planning to receive EPP must also be evaluated for appropriateness of radiation therapy (RT) by a radiation oncologist within 14 days prior to step 2 registration
- Patients must have a Zubrod performance status of 0-1 documented within 28 days prior to step 2 registration
- Patients must have postoperative predicted forced expiratory volume in 1 second (FEV1) \> 35% prior to surgery obtained within 28 days prior to step 2 registration; pulmonary function tests to ascertain these values must be obtained within 28 days prior to Step 2 registration
- Patients must have postoperative predicted carbon monoxide diffusing capability (DLCO) \> 35% prior to surgery obtained within 28 days prior to step 2 registration; pulmonary function tests to ascertain these values must be obtained within 28 days prior to Step 2 registration
- Patient must have received at least two cycles of triplet neoadjuvant therapy (all three drugs) during step 1
- Patient must be registered to step 2 no less than 21 days and no more than 90 days after the end of their final cycle of neoadjuvant therapy
- STEP 3: MAINTENANCE
- Patient must have received either P/D or EPP and must have recovered from all effects of surgery with adequate wound healing; patients who received radiation therapy (RT) must be registered to step 3 within 90 days after discontinuing RT; patients who did not receive RT must be registered to step 3 within 90 days after surgery
- Patient must have a CT of chest/abdomen/pelvis with contrast or FDG-PET/CT scan within 28 days prior to step 3 registration; patient must not have evidence of progression per RECIST 1.1 or modified RECIST for pleural tumors
- Patient may have discontinued RT early due to toxicity or other reasons
- Patients must have a Zubrod performance status of 0-1 documented within 28 days prior to step 3 registration
- ANC \> 1,500/mcl (documented within 28 days prior to step 3 registration)
- Hemoglobin \> 9 g/dl (documented within 28 days prior to step 3 registration)
- Platelets \> 100,000/mcl (documented within 28 days prior to step 3 registration)
- Creatinine \< 1.5 x ULN (documented within 28 days prior to step 3 registration)
- Total bilirubin =\< 1.5 x upper limit of normal (ULN) (within 28 days prior to step 3 registration)
- Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =\< 3 x ULN (within 28 days prior to step 3 registration)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (174)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Mary Greeley Medical Center Coordinator of this site? Confirm its status | Ames | United States | Unknown status |
| McFarland Clinic - Ames Coordinator of this site? Confirm its status | Ames | United States | Unknown status |
| Community Hospital of Anaconda Coordinator of this site? Confirm its status | Anaconda | United States | Unknown status |
| PCR Oncology Coordinator of this site? Confirm its status | Arroyo Grande | United States | Unknown status |
| Rush-Copley Medical Center Coordinator of this site? Confirm its status | Aurora | United States | Unknown status |
| CommonSpirit Saint Joseph Hospital - Bardstown Coordinator of this site? Confirm its status | Bardstown | United States | Unknown status |
| Overlake Medical Center Coordinator of this site? Confirm its status | Bellevue | United States | Unknown status |
| Billings Clinic Cancer Center Coordinator of this site? Confirm its status | Billings | United States | Unknown status |
| Illinois CancerCare-Bloomington Coordinator of this site? Confirm its status | Bloomington | United States | Unknown status |
| Saint Alphonsus Cancer Care Center-Boise Coordinator of this site? Confirm its status | Boise | United States | Unknown status |
| Parkland Health Center-Bonne Terre Coordinator of this site? Confirm its status | Bonne Terre | United States | Unknown status |
| McFarland Clinic - Boone Coordinator of this site? Confirm its status | Boone | United States | Unknown status |
| Bozeman Health Deaconess Hospital Coordinator of this site? Confirm its status | Bozeman | United States | Unknown status |
| Henry Ford Cancer Institute-Downriver Coordinator of this site? Confirm its status | Brownstown | United States | Unknown status |
| Saint Joseph Regional Cancer Center Coordinator of this site? Confirm its status | Bryan | United States | Unknown status |
| Saint Anne Hospital Coordinator of this site? Confirm its status | Burien | United States | Unknown status |
| Saint Alphonsus Cancer Care Center-Caldwell Coordinator of this site? Confirm its status | Caldwell | United States | Unknown status |
| Illinois CancerCare-Canton Coordinator of this site? Confirm its status | Canton | United States | Unknown status |
| Mercy Cancer Center - Cape Girardeau Coordinator of this site? Confirm its status | Cape Girardeau | United States | Unknown status |
| Saint Francis Medical Center Coordinator of this site? Confirm its status | Cape Girardeau | United States | Unknown status |
| Memorial Hospital of Carbondale Coordinator of this site? Confirm its status | Carbondale | United States | Unknown status |
| SIH Cancer Institute Coordinator of this site? Confirm its status | Carterville | United States | Unknown status |
| Illinois CancerCare-Carthage Coordinator of this site? Confirm its status | Carthage | United States | Unknown status |
| Centralia Oncology Clinic Coordinator of this site? Confirm its status | Centralia | United States | Unknown status |
| Medical University of South Carolina Coordinator of this site? Confirm its status | Charleston | United States | Unknown status |
| University of Virginia Cancer Center Coordinator of this site? Confirm its status | Charlottesville | United States | Unknown status |
| Memorial Hospital Coordinator of this site? Confirm its status | Chattanooga | United States | Unknown status |
| TriHealth Cancer Institute-Anderson Coordinator of this site? Confirm its status | Cincinnati | United States | Unknown status |
| Bethesda North Hospital Coordinator of this site? Confirm its status | Cincinnati | United States | Unknown status |
| Good Samaritan Hospital - Cincinnati Coordinator of this site? Confirm its status | Cincinnati | United States | Unknown status |
| TriHealth Cancer Institute-Westside Coordinator of this site? Confirm its status | Cincinnati | United States | Unknown status |
| Henry Ford Macomb Hospital-Clinton Township Coordinator of this site? Confirm its status | Clinton Township | United States | Unknown status |
| Mercy Cancer Center-West Lakes Coordinator of this site? Confirm its status | Clive | United States | Unknown status |
| UI Health Care Mission Cancer and Blood - West Des Moines Clinic Coordinator of this site? Confirm its status | Clive | United States | Unknown status |
| Billings Clinic-Cody Coordinator of this site? Confirm its status | Cody | United States | Unknown status |
| Kootenai Health - Coeur d'Alene Coordinator of this site? Confirm its status | Coeur d'Alene | United States | Unknown status |
| Rocky Mountain Cancer Centers-Penrose Coordinator of this site? Confirm its status | Colorado Springs | United States | Unknown status |
| Penrose-Saint Francis Healthcare Coordinator of this site? Confirm its status | Colorado Springs | United States | Unknown status |
| UT MD Anderson - The Woodlands Coordinator of this site? Confirm its status | Conroe | United States | Unknown status |
| Commonwealth Cancer Center-Corbin Coordinator of this site? Confirm its status | Corbin | United States | Unknown status |
| Alegent Health Mercy Hospital Coordinator of this site? Confirm its status | Council Bluffs | United States | Unknown status |
| Greater Regional Medical Center Coordinator of this site? Confirm its status | Creston | United States | Unknown status |
| UT Southwestern/Simmons Cancer Center-Dallas Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Carle at The Riverfront Coordinator of this site? Confirm its status | Danville | United States | Unknown status |
| Cancer Care Specialists of Illinois - Decatur Coordinator of this site? Confirm its status | Decatur | United States | Unknown status |
| Decatur Memorial Hospital Coordinator of this site? Confirm its status | Decatur | United States | Unknown status |
| AdventHealth Porter Coordinator of this site? Confirm its status | Denver | United States | Unknown status |
| UI Health Care Mission Cancer and Blood - Laurel Clinic Coordinator of this site? Confirm its status | Des Moines | United States | Unknown status |
| Mercy Medical Center - Des Moines Coordinator of this site? Confirm its status | Des Moines | United States | Unknown status |
| Henry Ford Hospital Coordinator of this site? Confirm its status | Detroit | United States | Unknown status |
| City of Hope Comprehensive Cancer Center Coordinator of this site? Confirm its status | Duarte | United States | Unknown status |
| CommonSpirit Cancer Center Mercy Coordinator of this site? Confirm its status | Durango | United States | Unknown status |
| Mercy Medical Center Coordinator of this site? Confirm its status | Durango | United States | Unknown status |
| Carle Physician Group-Effingham Coordinator of this site? Confirm its status | Effingham | United States | Unknown status |
| Crossroads Cancer Center Coordinator of this site? Confirm its status | Effingham | United States | Unknown status |
| Saint Elizabeth Hospital Coordinator of this site? Confirm its status | Enumclaw | United States | Unknown status |
| Illinois CancerCare-Eureka Coordinator of this site? Confirm its status | Eureka | United States | Unknown status |
| Saint Francis Hospital Coordinator of this site? Confirm its status | Federal Way | United States | Unknown status |
| McFarland Clinic - Trinity Cancer Center Coordinator of this site? Confirm its status | Fort Dodge | United States | Unknown status |
| Western Illinois Cancer Treatment Center Coordinator of this site? Confirm its status | Galesburg | United States | Unknown status |
| Illinois CancerCare-Galesburg Coordinator of this site? Confirm its status | Galesburg | United States | Unknown status |
| Mountain Blue Cancer Care Center Coordinator of this site? Confirm its status | Golden | United States | Unknown status |
| Nebraska Cancer Specialists/Oncology Hematology West PC Coordinator of this site? Confirm its status | Grand Island | United States | Unknown status |
| Benefis Sletten Cancer Institute Coordinator of this site? Confirm its status | Great Falls | United States | Unknown status |
| Great Falls Clinic Coordinator of this site? Confirm its status | Great Falls | United States | Unknown status |
| Saint Peter's Community Hospital Coordinator of this site? Confirm its status | Helena | United States | Unknown status |
| Comprehensive Cancer Centers of Nevada - Henderson Coordinator of this site? Confirm its status | Henderson | United States | Unknown status |
| Oncology Las Vegas - Henderson Coordinator of this site? Confirm its status | Henderson | United States | Unknown status |
| Pulmonary Medicine Center of Chattanooga-Hixson Coordinator of this site? Confirm its status | Hixson | United States | Unknown status |
| CHI Saint Vincent Cancer Center Hot Springs Coordinator of this site? Confirm its status | Hot Springs | United States | Unknown status |
| UT MD Anderson Cancer Center Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| UT MD Anderson - West Houston Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| Lyndon Baines Johnson General Hospital Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| Allegiance Health Coordinator of this site? Confirm its status | Jackson | United States | Unknown status |
| Baptist MD Anderson Cancer Center Coordinator of this site? Confirm its status | Jacksonville | United States | Unknown status |
| McFarland Clinic - Jefferson Coordinator of this site? Confirm its status | Jefferson | United States | Unknown status |
| MU Health Care Goldschmidt Cancer Center Coordinator of this site? Confirm its status | Jefferson City | United States | Unknown status |
| Logan Health Medical Center Coordinator of this site? Confirm its status | Kalispell | United States | Unknown status |
| CHI Health Good Samaritan Coordinator of this site? Confirm its status | Kearney | United States | Unknown status |
| Fred and Pamela Buffett Cancer Center - Kearney Coordinator of this site? Confirm its status | Kearney | United States | Unknown status |
| Illinois CancerCare-Kewanee Clinic Coordinator of this site? Confirm its status | Kewanee | United States | Unknown status |
| Rocky Mountain Cancer Centers-Lakewood Coordinator of this site? Confirm its status | Lakewood | United States | Unknown status |
| Saint Clare Hospital Coordinator of this site? Confirm its status | Lakewood | United States | Unknown status |
| CommonSpirit Saint Anthony Hospital Cancer Center Coordinator of this site? Confirm its status | Lakewood | United States | Unknown status |
| Radiation Oncology Centers of Nevada Southeast Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| OptumCare Cancer Care at Charleston Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| OptumCare Cancer Care at MountainView Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| OptumCare Cancer Care at Fort Apache Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Radiation Oncology Centers of Nevada Central Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Comprehensive Cancer Centers of Nevada - Northwest Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Comprehensive Cancer Centers of Nevada-Summerlin Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Comprehensive Cancer Centers of Nevada - Central Valley Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Alliance for Childhood Diseases/Cure 4 the Kids Foundation Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Comprehensive Cancer Centers of Nevada Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Lawrence Memorial Hospital Coordinator of this site? Confirm its status | Lawrence | United States | Unknown status |
| Cancer Centers of Southwest Oklahoma Research Coordinator of this site? Confirm its status | Lawton | United States | Unknown status |
| UT MD Anderson - League City Coordinator of this site? Confirm its status | League City | United States | Unknown status |
| Saint Joseph Radiation Oncology Resource Center Coordinator of this site? Confirm its status | Lexington | United States | Unknown status |
| CommonSpirit Saint Joseph Medical Center - East Lexington Coordinator of this site? Confirm its status | Lexington | United States | Unknown status |
| Saint Elizabeth Regional Medical Center Coordinator of this site? Confirm its status | Lincoln | United States | Unknown status |
| AdventHealth Littleton Coordinator of this site? Confirm its status | Littleton | United States | Unknown status |
| CommonSpirit Saint Joseph Hospital London Coordinator of this site? Confirm its status | London | United States | Unknown status |
| Longmont United Hospital Coordinator of this site? Confirm its status | Longmont | United States | Unknown status |
| Rocky Mountain Cancer Centers-Longmont Coordinator of this site? Confirm its status | Longmont | United States | Unknown status |
| Saints Mary and Elizabeth Hospital Coordinator of this site? Confirm its status | Louisville | United States | Unknown status |
| Jewish Hospital Coordinator of this site? Confirm its status | Louisville | United States | Unknown status |
| UofL Health Medical Center Northeast Coordinator of this site? Confirm its status | Louisville | United States | Unknown status |
| Illinois CancerCare-Macomb Coordinator of this site? Confirm its status | Macomb | United States | Unknown status |
| McFarland Clinic - Marshalltown Coordinator of this site? Confirm its status | Marshalltown | United States | Unknown status |
| Carle Physician Group-Mattoon/Charleston Coordinator of this site? Confirm its status | Mattoon | United States | Unknown status |
| Idaho Urologic Institute-Meridian Coordinator of this site? Confirm its status | Meridian | United States | Unknown status |
| Community Medical Center Coordinator of this site? Confirm its status | Missoula | United States | Unknown status |
| Saint Alphonsus Cancer Care Center-Nampa Coordinator of this site? Confirm its status | Nampa | United States | Unknown status |
| Ochsner Medical Center Jefferson Coordinator of this site? Confirm its status | New Orleans | United States | Unknown status |
| Cancer Care Center of O'Fallon Coordinator of this site? Confirm its status | O'Fallon | United States | Unknown status |
| University of Oklahoma Health Sciences Center Coordinator of this site? Confirm its status | Oklahoma City | United States | Unknown status |
| Alegent Health Bergan Mercy Medical Center Coordinator of this site? Confirm its status | Omaha | United States | Unknown status |
| Alegent Health Lakeside Hospital Coordinator of this site? Confirm its status | Omaha | United States | Unknown status |
| Alegent Health Immanuel Medical Center Coordinator of this site? Confirm its status | Omaha | United States | Unknown status |
| Hematology and Oncology Consultants PC Coordinator of this site? Confirm its status | Omaha | United States | Unknown status |
| Memorial GYN Plus Coordinator of this site? Confirm its status | Ooltewah | United States | Unknown status |
| Illinois CancerCare-Ottawa Clinic Coordinator of this site? Confirm its status | Ottawa | United States | Unknown status |
| Midlands Community Hospital Coordinator of this site? Confirm its status | Papillion | United States | Unknown status |
| AdventHealth Parker Coordinator of this site? Confirm its status | Parker | United States | Unknown status |
| Rocky Mountain Cancer Centers-Parker Coordinator of this site? Confirm its status | Parker | United States | Unknown status |
| OSF Saint Francis Radiation Oncology at Pekin Coordinator of this site? Confirm its status | Pekin | United States | Unknown status |
| Illinois CancerCare-Pekin Coordinator of this site? Confirm its status | Pekin | United States | Unknown status |
| Illinois CancerCare-Peoria Coordinator of this site? Confirm its status | Peoria | United States | Unknown status |
| OSF Saint Francis Medical Center Coordinator of this site? Confirm its status | Peoria | United States | Unknown status |
| OSF Saint Francis Radiation Oncology at Peoria Cancer Center Coordinator of this site? Confirm its status | Peoria | United States | Unknown status |
| Methodist Medical Center of Illinois Coordinator of this site? Confirm its status | Peoria | United States | Unknown status |
| Illinois CancerCare-Peru Coordinator of this site? Confirm its status | Peru | United States | Unknown status |
| Valley Radiation Oncology Coordinator of this site? Confirm its status | Peru | United States | Unknown status |
| Mayo Clinic Hospital in Arizona Coordinator of this site? Confirm its status | Phoenix | United States | Unknown status |
| UPMC Hillman Cancer Center Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
| Kootenai Clinic Cancer Services - Post Falls Coordinator of this site? Confirm its status | Post Falls | United States | Unknown status |
| Harrison HealthPartners Hematology and Oncology-Poulsbo Coordinator of this site? Confirm its status | Poulsbo | United States | Unknown status |
| Illinois CancerCare-Princeton Coordinator of this site? Confirm its status | Princeton | United States | Unknown status |
| Rocky Mountain Cancer Centers - Pueblo Coordinator of this site? Confirm its status | Pueblo | United States | Unknown status |
| Saint Mary Corwin Medical Center Coordinator of this site? Confirm its status | Pueblo | United States | Unknown status |
| Radiation Oncology Associates Coordinator of this site? Confirm its status | Reno | United States | Unknown status |
| Saint Mary's Regional Medical Center Coordinator of this site? Confirm its status | Reno | United States | Unknown status |
| Renown Regional Medical Center Coordinator of this site? Confirm its status | Reno | United States | Unknown status |
| Valley Medical Center Coordinator of this site? Confirm its status | Renton | United States | Unknown status |
| UT Southwestern Clinical Center at Richardson/Plano Coordinator of this site? Confirm its status | Richardson | United States | Unknown status |
| Mayo Clinic in Rochester Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
| University of California Davis Comprehensive Cancer Center Coordinator of this site? Confirm its status | Sacramento | United States | Unknown status |
| Sainte Genevieve County Memorial Hospital Coordinator of this site? Confirm its status | Sainte Genevieve | United States | Unknown status |
| Kootenai Clinic Cancer Services - Sandpoint Coordinator of this site? Confirm its status | Sandpoint | United States | Unknown status |
| Mayo Clinic in Arizona Coordinator of this site? Confirm its status | Scottsdale | United States | Unknown status |
| University of Washington Medical Center - Montlake Coordinator of this site? Confirm its status | Seattle | United States | Unknown status |
| Fred Hutchinson Cancer Center Coordinator of this site? Confirm its status | Seattle | United States | Unknown status |
| Henry Ford Macomb Health Center - Shelby Township Coordinator of this site? Confirm its status | Shelby | United States | Unknown status |
| Jewish Hospital Medical Center South Coordinator of this site? Confirm its status | Shepherdsville | United States | Unknown status |
| Welch Cancer Center Coordinator of this site? Confirm its status | Sheridan | United States | Unknown status |
| Saint Joseph Medical Center Hematology and Oncology - Silverdale Coordinator of this site? Confirm its status | Silverdale | United States | Unknown status |
| Springfield Clinic Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Southern Illinois University School of Medicine Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Springfield Memorial Hospital Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Missouri Baptist Medical Center Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| UT MD Anderson - Sugar Land Coordinator of this site? Confirm its status | Sugar Land | United States | Unknown status |
| Missouri Baptist Sullivan Hospital Coordinator of this site? Confirm its status | Sullivan | United States | Unknown status |
| Southwest Illinois Health Services LLP Coordinator of this site? Confirm its status | Swansea | United States | Unknown status |
| Franciscan Research Center-Northwest Medical Plaza Coordinator of this site? Confirm its status | Tacoma | United States | Unknown status |
| Northwest Medical Specialties PLLC Coordinator of this site? Confirm its status | Tacoma | United States | Unknown status |
| Rocky Mountain Cancer Centers-Thornton Coordinator of this site? Confirm its status | Thornton | United States | Unknown status |
| The Carle Foundation Hospital Coordinator of this site? Confirm its status | Urbana | United States | Unknown status |
| Carle Cancer Center Coordinator of this site? Confirm its status | Urbana | United States | Unknown status |
| Henry Ford West Bloomfield Hospital Coordinator of this site? Confirm its status | West Bloomfield | United States | Unknown status |
| Mercy Medical Center-West Lakes Coordinator of this site? Confirm its status | West Des Moines | United States | Unknown status |
| Cancer Center of Kansas-Wichita Medical Arts Tower Coordinator of this site? Confirm its status | Wichita | United States | Unknown status |
| Ascension Via Christi Hospitals Wichita Coordinator of this site? Confirm its status | Wichita | United States | Unknown status |
| Cancer Center of Kansas - Wichita Coordinator of this site? Confirm its status | Wichita | United States | Unknown status |
| Rush-Copley Healthcare Center Coordinator of this site? Confirm its status | Yorkville | United States | Unknown status |
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