NCT03243539Active, not recruiting
Implementation of Neuro Lung Protective Ventilation
Implementation of Neuro Lung Protective Ventilation in Patients With Acute Brain Injury
Source: ClinicalTrials.gov · Last updated 8 Apr 2026
Brief summary (registry, in English)
Patients who experience lung injury are often placed on a ventilator to help them heal; however, if the ventilator volume settings are too high, it can cause additional lung injury. It is proven that using lower ventilator volume settings improves outcomes. In patients with acute brain injury, it is proven that maintaining a normal partial pressure of carbon dioxide in the arterial blood improves outcomes. Mechanical ventilator settings with higher volumes and higher breathing rates are sometimes required to maintain a normal partial pressure of carbon dioxide. These 2 goals of mechanical ventilation, using lower volumes to prevent additional lung injury but maintaining a normal partial pressure of carbon dioxide, are both important for patients with acute brain injury. The investigators have designed a computerized ventilator protocol in iCentra that matches the current standard of care for mechanical ventilation of patients with acute brain injury by targeting a normal partial pressure of carbon dioxide with the lowest ventilator volume required. This is a quality improvement study with the purpose of observing and measuring the effects of implementation of a standard of care mechanical ventilation protocol for patients with acute brain injury in the iCentra electronic medical record system at Intermountain Medical Center. We hypothesize that implementation of a standardized neuro lung protective ventilation protocol will be feasible, will achieve a target normal partial pressure of carbon dioxide, will decrease tidal volumes toward the target 6 mL/kg predicted body weight, and will improve outcomes.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 728 (estimated)
- First submitted
- 14 Jul 2017
- Start date
- 31 Aug 2017
- Primary completion date
- 31 Dec 2018
- Lead sponsor
- Colin Grissom
- Diseases
- Stroke
- NCT number
- NCT03243539
What you commit to
- Study type: Interventional
- Planned participants: 728
- From 31 Aug 2017 to the primary completion date, 31 Dec 2018
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Transition to comfort care in the emergency department or on the same day of admission to the ICU
- Death on the same day of admission to the emergency department or ICU
Who the study is looking for
- Acute brain injury due to non-traumatic causes (stroke, spontaneous intracranial hemorrhage, cerebral edema, anoxic brain injury) or traumatic brain injury.
- Initiation of mechanical ventilation in the emergency department or intensive care unit at an Intermountain Healthcare hospital
- Age ≥ 18 years
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Intermountain Medical Center Coordinator of this site? Confirm its status | Murray | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.