NCT03244722Completed
Maternal Metabolic and Molecular Changes Induced by Preconception Weight Loss and Their Effects on Birth Outcomes
Source: ClinicalTrials.gov · Last updated 4 Sept 2026
Brief summary (registry, in English)
Our hypothesis is that aggressive preconception weight loss in obese women will improve the metabolic health of the mother and the intrauterine environment. An optimized developmental environment will normalize fetal growth and improve clinical fetal and infant outcomes, and theoretically reduce future susceptibility to obesity and cardiometabolic disease.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 147 (actual)
- First submitted
- 5 Aug 2017
- Start date
- 10 Apr 2018
- Primary completion date
- 14 Jun 2025
- Lead sponsor
- University of Michigan
- Diseases
- Obesity
- NCT number
- NCT03244722
What you commit to
- Study type: Interventional
- Participants enrolled: 147
- From 10 Apr 2018 to the primary completion date, 14 Jun 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Recent use of anti-obesity drugs or appetite suppressants
- Previous bariatric surgery
Other illness
- Significant medical co-morbidities (e.g. heart, kidney, liver, autoimmune disease)
- Cancer other than minor skin cancers
- Conditions that would complicate pregnancy
Other
- Significant anemia
- Endometriosis AFS (American Fertility Society classification class III or IV)
- Progesterone \> 10 IU/ml
- Current pregnancy
- Use of sperm donor
Who the study is looking for
- BMI \> 30 ≤ 45 for obese participants OR
- BMI ≤ 25 for healthy body weight participants
- No known infertility
- No known risk factors for tubal disease
Age in the registry: 18 years to 40 years · Sex: Female · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Michigan Coordinator of this site? Confirm its status | Ann Arbor | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.