NCT03245346Completed
Effects of Epidural Anesthesia and Analgesia on the Prognosis in Patients Undergoing Pancreatic Cancer Surgery
Effects of Epidural Anesthesia and Analgesia on the Prognosis in Patients Undergoing Pancreatic Cancer Surgery: A Multi-center Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 19 May 2026
Brief summary (registry, in English)
The purpose of this randomized controlled trial is to investigate the effects of epidural anesthesia and analgesia on the overall survival，disease-free survival and recovery in patients undergoing pancreatic cancer surgery. This study will also evaluate the effects of this technique on neuroendocrine, stress and inflammatory response in these patients.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 540 (actual)
- First submitted
- 2 Aug 2017
- Start date
- 19 Dec 2017
- Primary completion date
- 30 Jun 2023
- Lead sponsor
- Fudan University
- Diseases
- Pancreatic cancer
- NCT number
- NCT03245346
What you commit to
- Study type: Interventional
- Participants enrolled: 540
- From 19 Dec 2017 to the primary completion date, 30 Jun 2023
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Laparoscopic surgery.
- Preoperative chemotherapy or radiotherapy.
- Long-term receiving β-blockers.
- Complicated with chronic inflammatory diseases, autoimmune diseases, or long-term receiving glucocorticoids or other immunosuppressants before surgery.
- Chronic opiate medication/drug abuse.
Other illness
- Allergic to any drugs used during the study.
- Complicated with severe mental illness, cognitive disorder or unable to collaborate during the study.
Lab values
- Abnormal coagulation functions (platelet count prior to surgery \<100000/ μL , APTT value is more than the normal value, INR \> 1.3 or clopidogrel that cannot be discontinued 7 days prior to surgery).
- Complicated with severe heart disease (NYHA classification \>3), severe renal insufficiency (serum creatinine \>1.8mg/dL or receiving renal replacement therapy), severe hepatic disease (Child-Pugh classification
- = C), diabetes (fasting blood glucose not in the range of 3.9-13.8 mmol/L ), or acute infectious diseases (WBC\>10000/μL) before surgery.
Other
- Pregnancy.
- BMI \> 35.
- All contraindications to epidural anesthesia and analgesia.
- Refuse to sign an informed consent form.
Who the study is looking for
- Undergoing elective pancreaticoduodenectomy for pancreatic cancer .
- ASA statusⅠ-Ⅲ.
- 18 years to 80 years （adults）.
- Able to understand, communicate and sign an informed consent form.
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Fudan University Shanghai Cancer Center Coordinator of this site? Confirm its status | Shanghai | China | Unknown status |
| Fudan University Zhongshan Hospital Coordinator of this site? Confirm its status | Shanghai | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.