NCT03246802Recruiting
Partial Prostate Salvage High Dose Rate Brachytherapy
High Dose Rate Partial Prostate Brachytherapy as Salvage Treatment for Local Failures After Previous External Beam Radiotherapy
Source: ClinicalTrials.gov · Last updated 29 Jun 2026
Brief summary (registry, in English)
A dose-response relationship for radiation in the management of prostate cancer is well established. Local recurrence of prostate cancer after external beam radiotherapy occurs in at least 40% of patients treated because of inability to deliver sufficient dose through external beam techniques. These patients respond well to re-irradiation using brachytherapy with about 50% of selected patients remaining free of recurrence 5 years after salvage. Advanced imaging using multiparametric Magnetic Resonance Imaging (mpMRI) allows identification of the site of recurrence, permitting partial prostate salvage brachytherapy. There is extensive literature on Low Dose Rate salvage brachytherapy but less on High Dose Rate.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- First submitted
- 3 Aug 2017
- Start date
- 1 Jan 2018
- Primary completion date
- 1 Jan 2032
- Lead sponsor
- British Columbia Cancer Agency
- Diseases
- Prostate cancer
- NCT number
- NCT03246802
What you commit to
- Study type: Interventional
- Planned participants: 30
- From 1 Jan 2018 to the primary completion date, 1 Jan 2032
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Not compliant with criteria above
- Unable to give informed consent
Who the study is looking for
- Age \>45 and Life expectancy \>10 years
- Previous External Beam Radiotherapy (EBRT) or LDR brachytherapy w
- \> 3 year interval since EBRT or LDR Brachytherapy
- No late toxicity from prior EBRT ≥ grade 2
- PSA \> nadir + 2 ng/ml and \< 10 ng/ml
- PSA Doubling time \> 6 months
- Radiographic evidence corresponding with site of recurrence in an under-dosed or untreated site. The recurrence should correspond to the site of original disease or be located in the seminal vesical +/- adjacent prostate as only area of recurrence (i.e. unifocal recurrence).
- Per Investigator, recurrence is suitable for implant with HDR brachytherapy and patient is suitable for procedure under anesthesia, spinal or general.
- Negative staging of the abdomen/pelvis and bones.
- Willing to provide informed consent
Age in the registry: 45 years to - · Sex: Male · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| BCCA Center for the Southern Interior Coordinator of this site? Confirm its status | Kelowna | Canada | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.