NCT03248284Recruiting
Immune-Competent Cell Manifestations in Psoriatic Arthritis Achilles Tendons
Stereological Quantification of Immune-Competent Cells in Biopsies From Painful Achilles Tendons of Psoriatic Arthritis Patients With Ultrasonic Verified Enthesitis: An Exploratory Prospective Cohort Study
Source: ClinicalTrials.gov · Last updated 5 Dec 2025
Brief summary (registry, in English)
Tendon pathologies (enthesitis) are a characteristic component of psoriatic arthritis (PsA), and are observed in 35% to 50% of PsA patients. The Achilles tendon is one of the most commonly affected sites. This condition often causes great morbidity and loss of quality of life, and response only suboptimal to current intervention strategies. One of the main obstacles for the development of effective treatment methods is that the disease mechanisms remain poorly understood. To our knowledge, no one has yet ascertained the presence and function of immune-competent cells and inflammatory markers in tendons tissue from PsA patients suffering from Achilles enthesitis.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 30 (estimated)
- First submitted
- 9 Aug 2017
- Start date
- 21 Aug 2017
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- Odense University Hospital
- Diseases
- Psoriasis, Psoriatic arthritis
- NCT number
- NCT03248284
What you commit to
- Study type: Observational
- Planned participants: 30
- From 21 Aug 2017 to the primary completion date, 31 Dec 2026
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Other inflammatory rheumatic diseases than PsA
Other
- Ultrasonic signs of complete rupture of the Achilles tendon
- Not wishing to participate or not suited for project evaluation
Who the study is looking for
- Fulfilling the CASPAR criteria
- Insertional Achilles tendon pain
- Ultrasonic findings of inflammatory disease at the painful Achilles tendon insertion (= enthesitis) defined as abnormally hypoechoic (loss of normal fibrillar architecture) and/or thickened tendon at its bony attachment, seen in two perpendicular planes that may exhibit a Doppler signal or bony changes, including enthesophytes, and erosions.
Age in the registry: 18 years to 70 years · Sex: All
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Odense University Hospital Coordinator of this site? Confirm its status | Odense | Denmark | Recruiting |
| Diagnostic Center Coordinator of this site? Confirm its status | Silkeborg | Denmark | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.