NCT03281889Active, not recruiting
Proton Craniospinal Irradiation With Bone Sparing to Decrease Growth Decrement From Radiation
Craniospinal Irradiation Using Proton Beam Scanning With Selective Vertebral Body/Bone Sparing to Improve Marrow Reserve and Decrease Growth Decrement for Children
Source: ClinicalTrials.gov · Last updated 7 Aug 2026
Brief summary (registry, in English)
This research study is studying proton radiation as a possible treatment for brain tumor that requires radiation. The radiation involved in this study is: -Proton Radiation
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 20 (actual)
- First submitted
- 8 Sept 2017
- Start date
- 4 Jan 2018
- Primary completion date
- 30 Jun 2027
- Lead sponsor
- Massachusetts General Hospital
- Diseases
- Childhood cancers
- NCT number
- NCT03281889
What you commit to
- Study type: Interventional
- Participants enrolled: 20
- From 4 Jan 2018 to the primary completion date, 30 Jun 2027
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Any prior therapeutic radiation therapy \> 500 cGy has been delivered.
- Pregnant females are excluded. Females of childbearing age/menstruating must confirm that either they are not sexually active or have a negative pregnancy test prior to initiation of radiation therapy.
- Patients that receive concurrent chemotherapy with the exception of concurrent Vincristine.
Other illness
- Individuals with a history of a different malignancy are ineligible except for the following circumstances: if they have been disease-free for at least 5 years and are deemed by the investigator to be a low-risk for recurrence of that malignancy; or, have had only cervical cancer in situ, or basal cell or squamous cell carcinoma of the skin.
- Any major uncontrolled or poorly controlled intercurrent illness that would limit compliance with study requirements.
Who the study is looking for
- Age ≥ 3 years and ≤ 18 years at the time of registration
- Histologically proven malignancy necessitating cranio-spinal irradiation. This will include patients with a diagnosis of medulloblastoma, Supratentorial primitive neuroectodermal tumor (SPNET), germ cell tumor (GCT), disseminated ependymoma, embryonal tumor with abundant neuropil and true rosettes (ETANTR), Atypical Teratoid/Rhabdoid Tumor (ATRT), and disseminated low-grade glioma (LGG).
- Life expectancy ≥ 12 months.
- Signed informed consent document and assent when appropriate.
- HGB of \> 10 g/L and PLT count \> 80 K/uL
Age in the registry: 3 years to 18 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Massachusetts General Hospital Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| MD Anderson Cancer Center Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.