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NCT03288220Recruiting

Influence of Brain Oscillation-Dependent TMS on Motor Function

Source: ClinicalTrials.gov · Last updated 5 Oct 2026

Brief summary (registry, in English)

Background: When people have a stroke, they often have difficulty moving their arms and hands. Transcranial magnetic stimulation (TMS) can improve how well people with and without stroke can move their arms and hands. But the effects of TMS are minor, and it doesn t work for everyone. Researchers want to study how to time brain stimulation so that the effects are more consistent. Objective: To understand how the brain responds to transcranial magnetic stimulation so that treatments for people with stroke can be improved. Eligibility: Adults ages 18 and older who had a stroke at least 6 months ago Healthy volunteers ages 50 and older Design: Participants will have up to 5 visits. At visit 1, participants will be screened with medical history and physical exam. Participants with stroke will also have TMS and surface electromyography (sEMG). For TMS, a brief electrical current will pass through a wire coil on the scalp. Participants may hear a click and feel a pull. Muscles may twitch. Participants may be asked to do simple movements during TMS. For sEMG, small electrodes will be attached to the skin and muscle activity will be recorded. At visit 2, participants will have magnetic resonance imaging (MRI). They will lie on a table that slides into a metal cylinder in a strong magnetic field. They will get earplugs for the loud noise. At visit 3, participants will have TMS, sEMG, and electroencephalography (EEG). For EEG, small electrodes on the scalp will record brainwaves. Participants will sit still, watch a movie, or do TMS. Participants may be asked to have 2 extra visits to redo procedures.

Status (registry)
Recruiting
Study type
Observational
Enrollment
114 (estimated)
First submitted
19 Sept 2017
Start date
11 Sept 2018
Primary completion date
30 Mar 2030
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
Diseases
Stroke
NCT number
NCT03288220

What you commit to

  • Study type: Observational
  • Planned participants: 114
  • From 11 Sept 2018 to the primary completion date, 30 Mar 2030
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

  • Healthy younger and older adults:
    • Presence of severe neurological or medical disorder (e.g., Parkinson s disease or multiple sclerosis).
    • History of seizures.
    • Chronic use of antipsychotic drugs (e.g., chlorpromazine or clozapine), tri-cyclic or other anti-depressants, benzodiazepines, or prescription stimulants.
    • TMS contraindications, such as:
    • Pacemaker, implanted pump, stimulator, cochlear implant, or metal objects inside the eye or skull.
    • Diagnosed severe hearing loss.
    • Current pregnancy.
    • Staff from our section.
  • Stroke patients:
    • Presence of severe neurological or medical disorder, other than stroke (e.g., Parkinson s disease or multiple sclerosis).
    • History of brainstem stroke.
    • History of seizures.
    • Chronic use of antipsychotic drugs (e.g., chlorpromazine or clozapine), benzodiazepines, or prescription stimulants.
    • TMS contraindications, such as:
    • Pacemaker, implanted pump, stimulator, cochlear implant, or metal objects inside
    • the eye or skull.
    • ---Diagnosed severe hearing loss.

Other

  • Current pregnancy.
  • Staff from our section.

Criteria the registry did not label

  • INCLUSION CRITERIA:
  • Healthy younger adults:
    • Ages 18 years to less than 50 years. (18 to 49)
    • Willingness/ability to provide informed consent.
    • Ability to induce a motor evoked potential in the muscle target of the upper extremity, as evaluated during the TMS Screening.
  • Healthy older adults:
    • Age 50 and over
    • Willingness/ability to provide informed consent.
    • Ability to induce a motor evoked potential in the muscle target of the upper extremity, as evaluated during the TMS Screening.
  • Stroke patients:
    • Age 18 and over.
    • Unilateral or bilateral upper limb paresis with the ability to voluntarily contract a finger, hand, wrist, or elbow muscle in the affected arm(s).
    • Stroke onset \> 6 months prior to participation.
    • Intact M1 sufficient to induce motor evoked potentials in the affected upper extremity following ipsilesional TMS, as evaluated during the TMS Screening.
    • Willingness/ability to provide informed consent.
    • If the investigator feels the individual s capacity to provide informed consent is questionable, the NIH Human Subjects Protection Unit (HSPU) will be requested to determine the individual s ability to consent.

Age in the registry: 18 years to 120 years · Sex: All · Accepts healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
National Institutes of Health Clinical Center
Coordinator of this site? Confirm its status		BethesdaUnited StatesRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.