NCT03298659Active, not recruiting
iFR Guided Multi-vessel Revascularization During Percutaneous Coronary Intervention for Acute Myocardial Infarction
Instantaneous Wave-free Ratio Guided Multi-vessel revascularizatiOn During Percutaneous Coronary intervEntion for Acute myocaRdial iNfarction (iMODERN)
Source: ClinicalTrials.gov · Last updated 14 Aug 2026
Brief summary (registry, in English)
In patients with acute ST-elevation myocardial infarction (STEMI), 40-60% have multi-vessel disease with an increased cardiovascular morbidity and mortality. Although it is not recommended to revascularize noninfarct lesions during the acute intervention, recent investigations suggest the opposite and show improved outcome after direct revascularization of noninfarct lesions. It is undesirable to risk procedure-related complications by treating noninfarct lesions without impaired flow. It is currently unknown whether pressure guided revascularization of noninfarct lesions in the acute phase improves outcome compared to the current guidelines. The iMODERN trial aims to compare an iFR-guided intervention of noninfarct lesions during the acute intervention with a deferred stress perfusion CMR-guided strategy during the outpatient follow-up, to determine the optimal therapeutic approach for STEMI patients with multivessel lesions.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 1146 (actual)
- First submitted
- 18 Sept 2017
- Start date
- 21 Dec 2017
- Primary completion date
- 28 Oct 2025
- Lead sponsor
- Radboud University Medical Center
- Diseases
- Coronary artery disease
- NCT number
- NCT03298659
What you commit to
- Study type: Interventional
- Participants enrolled: 1146
- From 21 Dec 2017 to the primary completion date, 28 Oct 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of ST-elevation myocardial infarction or coronary artery bypass graft
- Hemodynamic instability, respiratory failure, Kilips class ≥III
- Known contra-indications for stress CMR (e.g.: severe claustrophobia, metal implants, severe renal failure, severe astma)
Lab values
- Known GFR\<30 ml/min
Other
- Refusal or inability to provide informed consent
- Life expectancy due to noncardiovascular co-morbidity of less than 12 months
- Chronic total occlusion
- Left main stem stenosis (\>50%)
- Residual noninfarct lesion in infarct coronary artery
- Complex noninfarct target lesions
- Pregnancy
Who the study is looking for
- Age 18 years and older
- Clinical presentation of STEMI and successful primary PCI within 12 hours from onset of symptoms
- One or more other, noninfarct coronary artery lesions of \>50% stenosis and feasible to be revascularized (i.e., minimal diameter 2mm)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Radboudumc Coordinator of this site? Confirm its status | Nijmegen | Netherlands | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.