NCT03305588Active, not recruiting
RAD 1601: EDGE Radiosurgery for Intractable Essential Tremor and Tremor-Dominant Parkinson's Disease
RAD 1601: Pilot Trial of Frameless Virtual Cone Stereotactic Radiosurgical Thalamotomy for Intractable Tremor and Advanced Functional Connectivity Parcellation of the Thalamus
Source: ClinicalTrials.gov · Last updated 9 Mar 2026
Brief summary (registry, in English)
To determine the efficacy of frameless Virtual Cone Radiosurgical Thalamotomy for medically refractory tremor resulting from either Essential Tremor or Tremor-Dominant Parkinson's Disease with the Fahn-Tolosa-Marin Tremor Rating Scale (FTMTRS) in patients who are not candidates for deep brain stimulation (DBS).
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 40 (actual)
- First submitted
- 4 Oct 2017
- Start date
- 5 Dec 2017
- Primary completion date
- 1 Oct 2025
- Lead sponsor
- University of Alabama at Birmingham
- Diseases
- Parkinson disease
- NCT number
- NCT03305588
What you commit to
- Study type: Interventional
- Participants enrolled: 40
- From 5 Dec 2017 to the primary completion date, 1 Oct 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients who have had prior radiosurgery or therapeutic brain radiation therapy.
Other
- Patients with medical contra-indications to MRI imaging (e.g. pacemaker).
Who the study is looking for
- Patients with medical refractory essential tremor or tremor-dominant Parkinson's disease that are not candidates for deep brain stimulation (DBS), either by medical/surgical co-morbidities or by choice.
- Patients must have an ECOG status of 0, 1, or 2.
- Patients must be at least 18 years of age.
- All patients must be given written informed consent.
Age in the registry: 18 years to 99 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Alabama at Birmingham (UAB) Hazelrig-Salter Radiation Oncology Center Coordinator of this site? Confirm its status | Birmingham | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.