NCT03313895Completed
The Combined Aerobic Exercise and Cognitive Training (ACT) Trial: The ACT Trial
Efficacy and Mechanisms of Combined Aerobic Exercise and Cognitive Training (ACT) in MCI
Source: ClinicalTrials.gov · Last updated 25 Apr 2025
Brief summary (registry, in English)
This multi-site clinical trial occurs at the University of Minnesota and University of Rochester. It tests the efficacy and additive/synergistic effects of an ACT intervention on cognition and relevant mechanisms (aerobic fitness, Alzheimer's disease \[AD\] signature cortical thickness, and default mode network \[DMN\]) in older adults with amnestic MCI (aMCI).
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 146 (actual)
- First submitted
- 6 Oct 2017
- Start date
- 5 Jul 2018
- Primary completion date
- 17 Jul 2024
- Lead sponsor
- Arizona State University
- Diseases
- Alzheimer disease
- NCT number
- NCT03313895
What you commit to
- Study type: Interventional
- Participants enrolled: 146
- From 5 Jul 2018 to the primary completion date, 17 Jul 2024
- 4 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Resting heart rate (HR) ≤50 due to arrhythmia or ≥100 beats/min
- Neurological (e.g., dementia, head trauma), psychiatric (e.g., bipolar, schizophrenia, or depression), or substance dependency (alcohol or chemical dependency) in the past 5 years that are the main contributor to MCI
- Contraindications to exercise, e.g. unstable angina, recent surgery
- New symptoms or diseases that have not been evaluated by a health care provider
Other
- Geriatric Depression Scale \< 5
- Current enrollment in another intervention study related to cognitive improvement (reduce confounding effects on outcomes)
- Abnormal MRI findings
Who the study is looking for
- A clinical diagnosis of MCI
- Community-dwelling
- Age 65 years and older
- English-speaking
- Adequate visual acuity
- Verified exercise safety by medical provider
- Stable on drugs affecting cognitive and psychological status
- Verified MRI safety
- Capacity to consent
Age in the registry: 65 years to - · Sex: All · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Minnesota Coordinator of this site? Confirm its status | Minneapolis | United States | Unknown status |
| Arizona State University Coordinator of this site? Confirm its status | Phoenix | United States | Unknown status |
| University of Rochester Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
| Stanford University Coordinator of this site? Confirm its status | Stanford | United States | Unknown status |
Related publications
- Efficacy of sequential aerobic exercise and cognitive training in older adults with amnestic mild cognitive impairment.Aging Health Res · 2026 · PMID 42524288
This page is information, not medical advice. Discuss any trial with your doctor.