NCT03338790CompletedPhase 2
An Investigational Immunotherapy Study of Nivolumab in Combination With Rucaparib, Docetaxel, or Enzalutamide in Metastatic Castration-resistant Prostate Cancer
A Phase 2 Study of Nivolumab in Combination With Either Rucaparib, Docetaxel, or Enzalutamide in Men With Castration-resistant Metastatic Prostate Cancer
Source: ClinicalTrials.gov · Last updated 27 Jan 2026
Brief summary (registry, in English)
The purpose of this study is to assess safety and efficacy of nivolumab in combination with rucaparib, docetaxel, or enzalutamide in participants with castration-resistant prostate cancer that has spread.
- Status (registry)
- Completed
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 292 (actual)
- First submitted
- 8 Nov 2017
- Start date
- 19 Dec 2017
- Primary completion date
- 13 Jan 2021
- Lead sponsor
- Bristol-Myers Squibb
- Diseases
- Prostate cancer
- NCT number
- NCT03338790
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 292
- From 19 Dec 2017 to the primary completion date, 13 Jan 2021
- 66 sites in 11 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Participants must have recovered from the effects of major surgery requiring general anesthesia or significant traumatic injury at least 14 days before treatment arm assignment
- Other protocol defined inclusion/exclusion criteria could apply
Other illness
- Prior malignancy active within the previous 3 years except for locally curable cancers that have been apparently cured, such as basal or squamous cell skin cancer, superficial bladder cancer, or carcinoma in situ of the breast
Other
- Participants with active brain metastases
Who the study is looking for
- Histologic confirmation of adenocarcinoma of the prostate
- Evidence of stage IV disease on previous bone, CT, and/or MRI scan
- Ongoing androgen deprivation therapy (ADT) with a gonadotropin-releasing hormone (GnRH) analogue or bilateral orchiectomy
- Mandatory plasma and fresh or archival tumor tissue must be submitted
Age in the registry: 18 years to - · Sex: Male · Does not accept healthy volunteers
Sites (66)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Local Institution - 0044 Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| Local Institution - 0043 Coordinator of this site? Confirm its status | CABA | Argentina | Unknown status |
| Local Institution - 0052 Coordinator of this site? Confirm its status | CABA | Argentina | Unknown status |
| Local Institution - 0042 Coordinator of this site? Confirm its status | Capital Federal | Argentina | Unknown status |
| Local Institution - 0062 Coordinator of this site? Confirm its status | Villa Siburu | Argentina | Unknown status |
| Local Institution - 0015 Coordinator of this site? Confirm its status | Camperdown | Australia | Unknown status |
| Local Institution - 0050 Coordinator of this site? Confirm its status | Clayton | Australia | Unknown status |
| Local Institution - 0016 Coordinator of this site? Confirm its status | Elizabeth Vale | Australia | Unknown status |
| Local Institution - 0013 Coordinator of this site? Confirm its status | Heidelberg | Australia | Unknown status |
| Local Institution - 0014 Coordinator of this site? Confirm its status | South Brisbane | Australia | Unknown status |
| Local Institution - 0017 Coordinator of this site? Confirm its status | Westmead | Australia | Unknown status |
| Local Institution - 0020 Coordinator of this site? Confirm its status | Belo Horizonte | Brazil | Unknown status |
| Local Institution - 0074 Coordinator of this site? Confirm its status | Belo Horizonte | Brazil | Unknown status |
| Local Institution - 0022 Coordinator of this site? Confirm its status | Campinas | Brazil | Unknown status |
| Local Institution - 0075 Coordinator of this site? Confirm its status | Curitiba | Brazil | Unknown status |
| Local Institution - 0018 Coordinator of this site? Confirm its status | Ijuí | Brazil | Unknown status |
| Local Institution - 0021 Coordinator of this site? Confirm its status | Porto Alegre | Brazil | Unknown status |
| Local Institution - 0019 Coordinator of this site? Confirm its status | Rio de Janeiro | Brazil | Unknown status |
| Local Institution - 0073 Coordinator of this site? Confirm its status | São Paulo | Brazil | Unknown status |
| Local Institution - 0071 Coordinator of this site? Confirm its status | São Paulo | Brazil | Unknown status |
| Local Institution - 0055 Coordinator of this site? Confirm its status | Hamilton | Canada | Unknown status |
| Local Institution - 0067 Coordinator of this site? Confirm its status | Kelowna | Canada | Unknown status |
| Local Institution - 0059 Coordinator of this site? Confirm its status | Moncton | Canada | Unknown status |
| Local Institution - 0066 Coordinator of this site? Confirm its status | Montreal | Canada | Unknown status |
| Local Institution - 0056 Coordinator of this site? Confirm its status | Québec | Canada | Unknown status |
| Local Institution - 0034 Coordinator of this site? Confirm its status | Santiago | Chile | Unknown status |
| Local Institution - 0051 Coordinator of this site? Confirm its status | Viña del Mar | Chile | Unknown status |
| Local Institution - 0026 Coordinator of this site? Confirm its status | Medellín | Colombia | Unknown status |
| Local Institution - 0027 Coordinator of this site? Confirm its status | Montería | Colombia | Unknown status |
| Local Institution - 0001 Coordinator of this site? Confirm its status | Essen | Germany | Unknown status |
| Local Institution - 0006 Coordinator of this site? Confirm its status | Göttingen | Germany | Unknown status |
| Local Institution - 0004 Coordinator of this site? Confirm its status | Heidelberg | Germany | Unknown status |
| Local Institution - 0002 Coordinator of this site? Confirm its status | Jena | Germany | Unknown status |
| Local Institution - 0007 Coordinator of this site? Confirm its status | Koblenz | Germany | Unknown status |
| Local Institution - 0064 Coordinator of this site? Confirm its status | München | Germany | Unknown status |
| Local Institution - 0045 Coordinator of this site? Confirm its status | Madrid | Spain | Unknown status |
| Local Institution - 0046 Coordinator of this site? Confirm its status | Pamplona | Spain | Unknown status |
| Local Institution - 0047 Coordinator of this site? Confirm its status | Seville | Spain | Unknown status |
| Local Institution - 0033 Coordinator of this site? Confirm its status | Besançon | France | Unknown status |
| Local Institution - 0032 Coordinator of this site? Confirm its status | Clermont-Ferrand | France | Unknown status |
| Local Institution - 0031 Coordinator of this site? Confirm its status | Lyon | France | Unknown status |
| Local Institution - 0030 Coordinator of this site? Confirm its status | Marseille | France | Unknown status |
| Local Institution - 0029 Coordinator of this site? Confirm its status | Villejuif | France | Unknown status |
| Local Institution - 0025 Coordinator of this site? Confirm its status | Culiacán | Mexico | Unknown status |
| Local Institution - 0048 Coordinator of this site? Confirm its status | Guadalajara | Mexico | Unknown status |
| Local Institution - 0061 Coordinator of this site? Confirm its status | Guadalajara | Mexico | Unknown status |
| Local Institution - 0054 Coordinator of this site? Confirm its status | León | Mexico | Unknown status |
| Local Institution - 0038 Coordinator of this site? Confirm its status | Albany | United States | Unknown status |
| Local Institution - 0053 Coordinator of this site? Confirm its status | Allentown | United States | Unknown status |
| Boston Medical Center Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Local Institution - 0036 Coordinator of this site? Confirm its status | Daphne | United States | Unknown status |
| Local Institution - 0012 Coordinator of this site? Confirm its status | Detroit | United States | Unknown status |
| Local Institution - 0041 Coordinator of this site? Confirm its status | Durham | United States | Unknown status |
| Local Institution - 0039 Coordinator of this site? Confirm its status | Fairfax | United States | Unknown status |
| Local Institution - 0069 Coordinator of this site? Confirm its status | Jackson | United States | Unknown status |
| Local Institution - 0065 Coordinator of this site? Confirm its status | Louisville | United States | Unknown status |
| Local Institution - 0009 Coordinator of this site? Confirm its status | Marietta | United States | Unknown status |
| Local Institution - 0037 Coordinator of this site? Confirm its status | Miami | United States | Unknown status |
| Local Institution - 0049 Coordinator of this site? Confirm its status | New Haven | United States | Unknown status |
| Tulane University Coordinator of this site? Confirm its status | New Orleans | United States | Unknown status |
| Local Institution - 0068 Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Local Institution - 0035 Coordinator of this site? Confirm its status | Omaha | United States | Unknown status |
| Local Institution - 0024 Coordinator of this site? Confirm its status | Portland | United States | Unknown status |
| Local Institution - 0010 Coordinator of this site? Confirm its status | Rancho Mirage | United States | Unknown status |
| Local Institution - 0040 Coordinator of this site? Confirm its status | Rockville | United States | Unknown status |
| Local Institution - 0011 Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.