NCT03345446Active, not recruiting
Circulating RNAs in Acute Congestive Heart Failure
Circulating RNAs in Acute Heart Failure
Source: ClinicalTrials.gov · Last updated 23 Oct 2025
Brief summary (registry, in English)
The purpose of this American Heart Association-funded and NIH-funded study is to examine circulating RNAs in the acute CHF setting, how they change with decongestive therapy, and their function in vitro and in vivo. The investigators are testing the hypothesis that ex-RNA levels change significantly during decongestion therapy and can be used as a marker of those individuals who respond to CHF therapy (in terms of cardiac structure or outcome). Additionally, the translational research design allows the investigators to assay the effects of these RNAs on tissue phenotypes in vitro.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 200 (estimated)
- First submitted
- 29 Aug 2017
- Start date
- 17 Aug 2016
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- Massachusetts General Hospital
- Diseases
- Heart failure
- NCT number
- NCT03345446
What you commit to
- Study type: Observational
- Planned participants: 200
- From 17 Aug 2016 to the primary completion date, 31 Dec 2026
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- End-stage non-cardiovascular diseases
- Known HIV/AIDS
- Cirrhosis
- Hemodialysis-dependent renal failure
- Post-heart transplant
- Malignancy within the last 1 year or clinically active rheumatologic or autoimmune illnesses
Other
- Hematocrit at time of consent \< 30%
- Pregnancy (as adjudicated by patient history)
- Ventricular assist device support
- Acute mechanical support on admission
Who the study is looking for
- Age \>/= 18 years of age
- Assessment of LV function within the last year or planned during hospital admission
- Acute CHF diagnosis, requiring clinical signs and/or symptoms (including exertional or rest dyspnea, orthopnea or PND) AND
- N-terminal pro-BNP level \> 1000 pg/ml or BNP \> 400 pg/ml, OR
- Clinical evidence of congestion:
- X-ray evidence of pulmonary edema or pleural effusions
- Elevated JVP, lower extremity edema, or rales on pulmonary examination
- Right heart catheterization evidence of elevated filling pressures (RA pressure \> 10 mmHg; PCWP \> 18 mmHg)
- Clinical response to IV diuretic therapy (as judged by a physician)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Beth Israel Deaconess Medical Center Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Massachusetts General Hospital Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Brigham and Women's Hospital Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.