NCT03347227Active, not recruiting
Characterization of Arrhythmia Substrate to Ablate Persistent Atrial Fibrillation
Characterization of Arrhythmia Substrate to Ablate Persistent Atrial Fibrillation (Coast-AF) Randomized Clinical Trial
Source: ClinicalTrials.gov · Last updated 15 Jun 2026
Brief summary (registry, in English)
A multicentre, parallel group, two arm, single-blinded randomized clinical trial, assessing the efficacy of a patient-tailored catheter ablation (CA) strategy guided by atrial low voltage area mapping in addition to pulmonary vein isolation (PVI) when compared to PVI alone in patients with persistent atrial fibrillation (AF).
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 510 (estimated)
- First submitted
- 15 Nov 2017
- Start date
- 24 Aug 2018
- Primary completion date
- 23 Apr 2026
- Lead sponsor
- Ottawa Heart Institute Research Corporation
- Diseases
- Atrial fibrillation
- NCT number
- NCT03347227
What you commit to
- Study type: Interventional
- Planned participants: 510
- From 24 Aug 2018 to the primary completion date, 23 Apr 2026
- 14 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- History of previous catheter ablation for AF or left atrial flutter;
- History of previous surgical ablation for AF;
- Contraindication to systemic oral anticoagulation therapy;
Other illness
- Severe valvular disease (mitral/aortic stenosis or regurgitation);
- Comorbid condition with life expectancy \< 1 year
Other
- Known intracardiac thrombus;
- Reversible causes of AF;
- Hypertrophic cardiomyopathy;
- Subjects that are pregnant or breastfeeding;
Who the study is looking for
- Age ≥18 years;
- Subjects with symptomatic persistent AF AND clinically indicated catheter ablation for AF;
- Persistent AF defined as a sustained episode beyond 3 months in duration;
- At least one episode of AF must have been documented on 12-lead ECG, Holter monitor, loop monitor or trans-telephonic monitor (TTM) within 36 months of enrollment in the study;
- Modified DR-FLASH score \>=3
- 4\. Subjects must be able to provide informed consent.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (14)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Libin Cardiovascular Institute Coordinator of this site? Confirm its status | Calgary | Canada | Unknown status |
| QEII Health Sciences Centre/Nova Scotia Health Authority Coordinator of this site? Confirm its status | Halifax | Canada | Unknown status |
| Hamilton General Hospital Coordinator of this site? Confirm its status | Hamilton | Canada | Unknown status |
| London Health Sciences Centre Coordinator of this site? Confirm its status | London | Canada | Unknown status |
| Centre Hospitalier de l'Universite de Montreal (CHUM) Coordinator of this site? Confirm its status | Montreal | Canada | Unknown status |
| Montreal Heart Institute Coordinator of this site? Confirm its status | Montreal | Canada | Unknown status |
| McGill University Health Centre Coordinator of this site? Confirm its status | Montreal | Canada | Unknown status |
| Southlake Regional Health Centre Coordinator of this site? Confirm its status | Newmarket | Canada | Unknown status |
| University of Ottawa Heart Institute Coordinator of this site? Confirm its status | Ottawa | Canada | Unknown status |
| Institute Universitaire de Cardiologie et Pneumologie du Quebec (IUCPQ) Coordinator of this site? Confirm its status | Québec | Canada | Unknown status |
| CIUSSS de L'Estrie - CHUS - Hopital Fleurimont Coordinator of this site? Confirm its status | Sherbrooke | Canada | Unknown status |
| St. Michael's Hospital Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| Rouge Valley Regional Heart Centre Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| Vancouver General Hospital Coordinator of this site? Confirm its status | Vancouver | Canada | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.