NCT03347786RecruitingPhase 1/2
Verapamil for Neuroprotection in Stroke
Intraarterial Verapamil for Neuroprotection in Ischemic Stroke
Source: ClinicalTrials.gov · Last updated 17 Jan 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The purpose of this research study is to test an experimental procedure called intra-arterial delivery of verapamil in patients diagnosed with acute ischemic stroke. This study investigates the safety of intra-arterial delivery of verapamil, a drug used to treat vasospasm (spasm of a blood vessel), and how it affects recovery from stroke. Recruitment is limited to patients that have received mechanical thrombectomy as standard of care.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 1/2
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 9 Nov 2017
- Start date
- 20 Apr 2017
- Primary completion date
- 31 Aug 2026
- Lead sponsor
- Global Neurosciences Institute
- Diseases
- Stroke
- NCT number
- NCT03347786
What you commit to
- Study type: Interventional · Phase 1/2
- Planned participants: 60
- From 20 Apr 2017 to the primary completion date, 31 Aug 2026
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous functional disability (modified Rankin \> 1)
Other illness
- Hepatic and/or renal insufficiency (LFT's\>3× upper limit of normal; CrCl \< 30ml/min)
- History of intolerance to verapamil
- Severe stroke (NIHSS\>22)
Lab values
- Thrombocytopenia (platelet count \<75,000/mm3)
Other
- Pregnancy or suspected pregnancy (pregnancy test will be done on women of child-bearing potential)
- Stuporous or comatose
- Unlikely to be available for 90 day follow-up
Who the study is looking for
- Written informed consent
- 18 years of age and over
- Acute onset focal neurologic deficit consistent with acute ischemic stroke, or computed tomographic scan consistent with acute cerebral ischemia
- Candidate for mechanical thrombectomy procedure
- Onset of symptoms less than 8 hours
- Measurable neurologic deficit (NIHSS ≥4)
- Willingness to follow up with rehabilitation therapy
- Anticipated life expectancy of at least 3 months
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| AtlantiCare Regional Medical Center Coordinator of this site? Confirm its status | Atlantic City | United States | Recruiting |
| St Mary Medical Center Coordinator of this site? Confirm its status | Langhorne | United States | Not yet recruiting |
| Crozer-Chester Medical Center Coordinator of this site? Confirm its status | Upland | United States | Completed |
This page is information, not medical advice. Discuss any trial with your doctor.