Intravascular Imaging- Versus Angiography-Guided Percutaneous Coronary Intervention For Complex Coronary Artery Disease

Other illness

• Known true anaphylaxis to contrast medium (not allergic reaction but anaphylactic shock)
• Non-cardiac co-morbid conditions are present with life expectancy \<1 year or that may result in protocol non-compliance (per site investigator's medical judgment)

Other

• Target lesions not amenable for PCI by operators' decision
• Cardiogenic shock (Killip class IV) at presentation
• Intolerance to Aspirin, Clopidogrel, Prasugrel, Ticagrelor, Heparin, or Everolimus
• Pregnancy or breast feeding
• Unwillingness or inability to comply with the procedures described in this protocol.

• Subject age ≥19 years old
• Coronary artery disease requiring PCI
• Patients with complex lesion
  • True bifurcation lesion (Medina 1,1,1/1,0,1/0,1,1) with side branch ≥2.5mm size
  • Chronic total occlusion (≥3 months) as target lesion
  • Unprotected LM disease PCI (LM ostium, body, distal LM bifurcation including non-true bifurcation)
  • Long coronary lesions (implanted stent ≥38 mm in length)
  • Multi-vessel PCI (≥2 vessels treated at one PCI session)
  • Multiple stents needed (≥3 more stent per patient)
  • In-stent restenosis lesion as target lesion
  • Severely calcified lesion (encircling calcium in angiography)
  • Ostial coronary lesion (LAD, LCX, RCA)
• Subject is able to verbally confirm understandings of risks, benefits and treatment alternatives of receiving invasive physiologic evaluation and PCI and he/she or his/her legally authorized representative provides written informed consent prior to any study related procedure.