NCT03386045Active, not recruiting
Optimal Prostate Study
Optimal Prostate Fractionation Study
Source: ClinicalTrials.gov · Last updated 29 Jan 2026
Brief summary (registry, in English)
To compare the toxicity, rate of local control, biochemical failure rate and quality of life of three different radiotherapy techniques (moderate hypofractionation, stereotactic body radiotherapy (SBRT) and standard radiotherapy plus 2 fractions of SBRT (BOOSTER)
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 503 (actual)
- First submitted
- 11 Dec 2017
- Start date
- 2 Oct 2018
- Primary completion date
- 1 Aug 2028
- Lead sponsor
- Royal North Shore Hospital
- Diseases
- Prostate cancer
- NCT number
- NCT03386045
What you commit to
- Study type: Interventional
- Participants enrolled: 503
- From 2 Oct 2018 to the primary completion date, 1 Aug 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous pelvic radiotherapy
- Prior total prostatectomy
Other
- Unwilling or unable to give informed consent
Who the study is looking for
- Histologically proven prostate adenocarcinoma
- PSA obtained within three months prior to enrolment
- ECOG performance status 0 to 2
- Ability to understand and the willingness to sign a written consent
- Suitable for high dose irradiation to the prostate
- To be eligible for the arm containing Stereotactic Booster alone approach patient must have the following
- No contraindication to MRI such as pacemaker and severe claustrophobia
- Patient must be able to have fiducial markers placed in the prostate
- Patient must be able to have hydrogel insertion at the same time as fiducial markers
- Must have IPSS less than 15
Age in the registry: 18 years to - · Sex: Male · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Royal North Shore Hospital Coordinator of this site? Confirm its status | St Leonards | Australia | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.