NCT03391362Active, not recruiting
Stereotactic Radiation in Patients With Small Cell Lung Cancer and 1-10 Brain Metastases
Stereotactic Radiation in Patients With Small Cell Lung Cancer and 1-10 Brain Metastases: A Single Arm, Phase II Trial
Source: ClinicalTrials.gov · Last updated 29 Sept 2026
Brief summary (registry, in English)
This research study is studying stereotactic radiation (focused/pinpoint radiation that targets each individual tumor but not the surrounding brain) instead of whole-brain radiation (radiation targeting the entire brain) as a possible treatment for patients with small cell lung cancer and 1-10 brain metastases. The intervention involved in this study is: -Stereotactic (focused, pinpoint) radiation
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 100 (actual)
- First submitted
- 21 Dec 2017
- Start date
- 23 Feb 2018
- Primary completion date
- 10 Apr 2024
- Lead sponsor
- Brigham and Women's Hospital
- Diseases
- Lung cancer
- NCT number
- NCT03391362
What you commit to
- Study type: Interventional
- Participants enrolled: 100
- From 23 Feb 2018 to the primary completion date, 10 Apr 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Participants who have undergone prior radiation for brain metastases.
- Participants who have received prophylactic cranial radiation for prevention of brain metastases
Other illness
- Participants with stage IV-V chronic kidney disease or end stage renal disease
- Participants with widespread, definitive leptomeningeal disease
Other
- Participants who cannot receive gadolinium
- Participants with a maximum tumor diameter exceeding 5 cm (if not resected)
- Participants with \>6 definitive lesions consistent with brain metastases
- Participants with inadequate mental capacity to complete quality of life questionnaires
Who the study is looking for
- Participants must have a biopsy-proven tumor consistent with small cell lung cancer and intracranial lesions radiographically consistent with or pathologically proven to be brain metastases. Patients who have undergone prior systemic therapy are eligible. Patients who have undergone resection of one or more brain metastases but who have not yet started adjuvant radiotherapy are eligible for the study.
- 1-10 definitive intracranial lesions must be present on MRI of the brain.
- Age \>=18 years at diagnosis of brain metastases.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Dana-Farber Cancer Institute Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.