NCT03400332CompletedPhase 1/2
A Study of BMS-986253 in Combination With Nivolumab or Nivolumab Plus Ipilimumab in Advanced Cancers
A Phase 1/2 Study of BMS-986253 in Combination With Nivolumab or Nivolumab Plus Ipilimumab in Advanced Cancers
Source: ClinicalTrials.gov · Last updated 24 Feb 2026
Brief summary (registry, in English)
The purpose of this study is to investigate experimental medication BMS-986253 in combination with Nivolumab or Nivolumab plus Ipilimumab in participants with advanced cancers.
- Status (registry)
- Completed
- Phase (registry)
- Phase 1/2
- Study type
- Interventional
- Enrollment
- 281 (actual)
- First submitted
- 12 Jan 2018
- Start date
- 12 Feb 2018
- Primary completion date
- 26 Apr 2024
- Lead sponsor
- Bristol-Myers Squibb
- Diseases
- Melanoma
- NCT number
- NCT03400332
- EudraCT number
- 2023-509061-20
What you commit to
- Study type: Interventional · Phase 1/2
- Participants enrolled: 281
- From 12 Feb 2018 to the primary completion date, 26 Apr 2024
- 72 sites in 12 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Participants with conditions requiring systemic treatment with either corticosteroids (\> 10mg prednisone equivalents) or other immunosuppressive medications within 14 days of study treatment administration
- Cytotoxic agents, unless at least 4 weeks have elapsed from last dose of prior anti-cancer therapy and initiation of study therapy
- Other protocol defined inclusion/exclusion criteria could apply
Other illness
- Participants with CNS metastases as the only site of active disease (Participants with controlled brain metastases; however, will be allowed to enroll)
- Participants with active, known or suspected autoimmune disease
- Participants with a known history of testing positive for Human Immunodeficiency Virus (HIV) or known Acquired Immunodeficiency Syndrome (AIDS)
Who the study is looking for
- Histologic or cytologic confirmation of a solid tumor that is advanced (metastatic, recurrent and/or unresectable) with measurable disease per RECIST v1.1
- At least 1 lesion accessible for biopsy
- Eastern Cooperative Oncology Group Performance Status of 0 or 1
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (72)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Local Institution - 0096 Coordinator of this site? Confirm its status | Adelaide | Australia | Unknown status |
| Local Institution - 0091 Coordinator of this site? Confirm its status | Ballarat Central | Australia | Unknown status |
| Local Institution - 0090 Coordinator of this site? Confirm its status | Melbourne | Australia | Unknown status |
| Local Institution - 0095 Coordinator of this site? Confirm its status | Melbourne | Australia | Unknown status |
| Local Institution - 0097 Coordinator of this site? Confirm its status | Perth | Australia | Unknown status |
| Local Institution - 0088 Coordinator of this site? Confirm its status | Wollstonecraft | Australia | Unknown status |
| Local Institution - 0037 Coordinator of this site? Confirm its status | Brussels | Belgium | Unknown status |
| Local Institution - 0036 Coordinator of this site? Confirm its status | Ghent | Belgium | Unknown status |
| Local Institution - 0082 Coordinator of this site? Confirm its status | Kortrijk | Belgium | Unknown status |
| Local Institution - 0030 Coordinator of this site? Confirm its status | Edmonton | Canada | Unknown status |
| Local Institution - 0056 Coordinator of this site? Confirm its status | Montreal | Canada | Unknown status |
| Local Institution - 0020 Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| Local Institution - 0055 Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| Local Institution - 0029 Coordinator of this site? Confirm its status | Vancouver | Canada | Unknown status |
| Local Institution - 0078 Coordinator of this site? Confirm its status | Victoria | Canada | Unknown status |
| Local Institution - 0040 Coordinator of this site? Confirm its status | Lausanne | Switzerland | Unknown status |
| Local Institution - 0041 Coordinator of this site? Confirm its status | Sankt Gallen | Switzerland | Unknown status |
| Local Institution - 0039 Coordinator of this site? Confirm its status | Zurich | Switzerland | Unknown status |
| Local Institution - 0034 Coordinator of this site? Confirm its status | Berlin | Germany | Unknown status |
| Local Institution - 0053 Coordinator of this site? Confirm its status | Hamburg | Germany | Unknown status |
| Local Institution - 0052 Coordinator of this site? Confirm its status | Mainz | Germany | Unknown status |
| Local Institution - 0054 Coordinator of this site? Confirm its status | Tübingen | Germany | Unknown status |
| Local Institution - 0022 Coordinator of this site? Confirm its status | Madrid | Spain | Unknown status |
| Local Institution - 0045 Coordinator of this site? Confirm its status | Madrid | Spain | Unknown status |
| Local Institution - 0023 Coordinator of this site? Confirm its status | Madrid | Spain | Unknown status |
| Local Institution - 0044 Coordinator of this site? Confirm its status | Málaga | Spain | Unknown status |
| Local Institution - 0021 Coordinator of this site? Confirm its status | Pamplona | Spain | Unknown status |
| Local Institution - 0047 Coordinator of this site? Confirm its status | Santiago de Compostela | Spain | Unknown status |
| Local Institution - 0067 Coordinator of this site? Confirm its status | Marseille | France | Unknown status |
| Local Institution - 0085 Coordinator of this site? Confirm its status | Nantes | France | Unknown status |
| Local Institution - 0068 Coordinator of this site? Confirm its status | Paris | France | Unknown status |
| Local Institution - 0102 Coordinator of this site? Confirm its status | Toulouse | France | Unknown status |
| Local Institution - 0069 Coordinator of this site? Confirm its status | Villejuif | France | Unknown status |
| Local Institution - 0019 Coordinator of this site? Confirm its status | Birmingham | United Kingdom | Unknown status |
| Local Institution - 0083 Coordinator of this site? Confirm its status | Glasgow | United Kingdom | Unknown status |
| Local Institution - 0024 Coordinator of this site? Confirm its status | Manchester | United Kingdom | Unknown status |
| Local Institution - 0043 Coordinator of this site? Confirm its status | Forlì | Italy | Unknown status |
| Local Institution - 0042 Coordinator of this site? Confirm its status | Milan | Italy | Unknown status |
| Local Institution - 0027 Coordinator of this site? Confirm its status | Naples | Italy | Unknown status |
| Local Institution - 0026 Coordinator of this site? Confirm its status | Rozzano-milano | Italy | Unknown status |
| Local Institution - 0071 Coordinator of this site? Confirm its status | Krakow | Poland | Unknown status |
| Local Institution - 0077 Coordinator of this site? Confirm its status | Warsaw | Poland | Unknown status |
| Local Institution - 0049 Coordinator of this site? Confirm its status | Lund | Sweden | Unknown status |
| Local Institution - 0004 Coordinator of this site? Confirm its status | Ann Arbor | United States | Unknown status |
| Local Institution - 0087 Coordinator of this site? Confirm its status | Atlanta | United States | Unknown status |
| Local Institution - 0100 Coordinator of this site? Confirm its status | Atlanta | United States | Unknown status |
| Local Institution - 0011 Coordinator of this site? Confirm its status | Austin | United States | Unknown status |
| Local Institution - 0060 Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Local Institution - 0012 Coordinator of this site? Confirm its status | Columbia | United States | Unknown status |
| Local Institution - 0010 Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Local Institution - 0017 Coordinator of this site? Confirm its status | Eugene | United States | Unknown status |
| Local Institution - 0015 Coordinator of this site? Confirm its status | Fairfax | United States | Unknown status |
| Local Institution - 0014 Coordinator of this site? Confirm its status | Fort Worth | United States | Unknown status |
| Local Institution - 0009 Coordinator of this site? Confirm its status | Greenville | United States | Unknown status |
| Local Institution - 0005 Coordinator of this site? Confirm its status | Hackensack | United States | Unknown status |
| Local Institution - 0018 Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| Local Institution - 0007 Coordinator of this site? Confirm its status | Lakewood | United States | Unknown status |
| Comprehensive Cancer Centers of Nevada Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Local Institution - 0099 Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| Local Institution - 0003 Coordinator of this site? Confirm its status | Lutherville | United States | Unknown status |
| Local Institution - 0101 Coordinator of this site? Confirm its status | Marietta | United States | Unknown status |
| Local Institution - 0032 Coordinator of this site? Confirm its status | New Brunswick | United States | Unknown status |
| Local Institution - 0002 Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Local Institution - 0025 Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Local Institution - 0008 Coordinator of this site? Confirm its status | Norfolk | United States | Unknown status |
| Local Institution - 0028 Coordinator of this site? Confirm its status | Oklahoma City | United States | Unknown status |
| Local Institution - 0076 Coordinator of this site? Confirm its status | Omaha | United States | Unknown status |
| Local Institution - 0001 Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
| Local Institution - 0058 Coordinator of this site? Confirm its status | Salt Lake City | United States | Unknown status |
| Local Institution - 0006 Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| Local Institution - 0059 Coordinator of this site? Confirm its status | Springdale | United States | Unknown status |
| Local Institution - 0013 Coordinator of this site? Confirm its status | Tyler | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.