NCT03423758Recruiting
Investigating the Genetic Basis of Pseudoexfoliation Syndrome, Angle-closure Glaucoma and Primary Open-angle Glaucoma
Source: ClinicalTrials.gov · Last updated 23 May 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
There is increasing evidence that there are genetic risk factors for several forms of glaucoma, such as glaucoma caused by pseudoexfoliation syndrome (PXF) ,primary angle closure glaucoma (PACG) and primary open-angle glaucoma (POAG). The aim of the present prospective, multi-center, case-control study is to identify susceptibility genes/loci for PXF, PACG and POAG using a whole genome association (WGA) approach.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 300 (estimated)
- First submitted
- 8 Jan 2018
- Start date
- 30 May 2017
- Primary completion date
- 30 Jan 2026
- Lead sponsor
- Medical University of Vienna
- Diseases
- Glaucoma
- NCT number
- NCT03423758
What you commit to
- Study type: Observational
- Planned participants: 300
- From 30 May 2017 to the primary completion date, 30 Jan 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Active or history of uveitis
- Secondary angle closure such as neovascular glaucoma or uveitis/inflammatory eye disease
Other
- Patients and subjects will be excluded if one or more of the following criteria apply:
- Neovascular glaucoma
- Inability to give informed consent
Who the study is looking for
- For patients with PXF:
- Patients with confirmed pseudoexfoliation syndrome (exfoliation glaucoma / pseudoexfoliation of the lens) in the medical history
- Informed consent
- Age 50 years or more
- For patients with PACG:
- Patients with confirmed acute primary angle closure (PAC) or primary angle closure glaucoma (PACG) in the medical history
- Informed consent
- Age 21 years or more
- For healthy controls:
- No evidence of PXF, glaucoma or uveitis during clinical examination or in the medical history
- No evidence of major ocular disease such as diabetic retinopathy, age related macular degeneration or conditions with genetic background during clinical examination or in the medical history
- Age more than 60 years
- Informed consent
- For patients with POAG:
- Patients with confirmed primary open angle glaucoma (POAG)
- No evidence of exfoliation glaucoma / pseudoexfoliation of the lens or pigment glaucoma
- Informed consent
- Age 30 or more
Age in the registry: 21 years to 105 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Department of Clinical Pharmacology, Medical University of Vienna Coordinator of this site? Confirm its status | Vienna | Austria | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.