NCT03429426Enrolling by invitation
Progression of Bone Erosions in Rheumatoid Arthritis Assessed by HR-pQCT and Conventional X-ray
An Observational Study of Bone Erosion Determination and Progression in Rheumatoid Arthritis Assessed by HR-pQCT and Conventional X-ray
Source: ClinicalTrials.gov · Last updated 13 Jan 2021 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Today, regular X-ray examination is not sufficiently sensitive for detecting progression of bone destruction in rheumatoid arthritis, but a new type of high-resolution CT scanner, the High-Resolution peripheral Quantitative Computed Tomography (HR-pQCT) can detect very early and minor joint injuries. The purpose of this study is to use HR-pQCT techniques to look at the damage and disease activity progression in the hand and wrist joints of patients with rheumatoid arthritis.
- Status (registry)
- Enrolling by invitation
- Study type
- Observational
- Enrollment
- 625 (estimated)
- First submitted
- 24 Jan 2018
- Start date
- 15 Feb 2018
- Primary completion date
- 1 Feb 2022
- Lead sponsor
- Aarhus University Hospital
- Diseases
- Rheumatoid arthritis
- NCT number
- NCT03429426
What you commit to
- Study type: Observational
- Planned participants: 625
- From 15 Feb 2018 to the primary completion date, 1 Feb 2022
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients who have previously suffered trauma in the form of fracture or luxation of the hand are excluded.
- Patients who have previously suffered trauma in the form of fracture or luxation of the hand are excluded.
- Patients who have previously suffered trauma in the form of fracture or luxation of the hand are excluded.
Other illness
- Evidence of active malignant disease.
- Evidence of malignant disease.
- Evidence of malignant disease.
- Earlier or present rheumatological disease or bone metabolic disease.
Lab values
- Impaired renal function (eGFR \<35ml/min).
- Impaired renal function (eGFR \<35ml/min).
Age
- Age over 18 years.
- Age over 18 years.
Other
- Hypo- or hyperthyroidism.
- Hypocalcaemia.
- Pregnancy. Pre-rheumatoid arthritis patients Inclusion criteria
- Anti-CCP 3 times the upper limit of the reference interval.
- Arthralgia.
- Ability and willingness to give written informed consent and to meet the requirements of the trial protocol.
- Pregnancy.
- Swelling of joints. Verified by clinical ultrasound.
- Hypo- or hyperthyroidism.
- Hypocalcaemia. Healthy subjects Inclusion criteria
- No joint complaints.
- Ability and willingness to give written informed consent and to meet the requirements of the trial protocol.
- Hypo- or hyperthyroidism.
- Hypocalcaemia.
- Positive anti-CCP.
- Pregnancy.
Criteria the registry did not label
- Rheumatoid arthritis patients Inclusion criteria
- Patients (\> 18 years) with rheumatoid arthritis ≥5 years according to the ACR/EULAR (2010) classification criteria or American Rheumatism Association 1987 revised criteria for the patients who were diagnosed before 2010.
- Patients who are receiving treatment on an outpatient basis.
- Ability and willingness to give written informed consent and to meet the requirements of the trial protocol.
Age in the registry: 18 years to - · Sex: All
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Department of Rheumatology, Aarhus University Hospital Coordinator of this site? Confirm its status | Aarhus | Denmark | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.