NCT03434678CompletedPhase 3
Use of Epidurals Intraoperatively for Patients Undergoing Pancreas Resection
Randomized Controlled Trial of Epidural-General Anesthesia Versus General Anesthesia for Open Pancreaticoduodenectomy: Influence on Complications and Overall Two Year Survival
Source: ClinicalTrials.gov · Last updated 30 Jul 2025
Brief summary (registry, in English)
The purpose of this study is to see if there is a difference in complications in patients who have an epidural started earlier (during their surgery) and used as part of the anesthetic in addition to using it for post operative pain compared with patients who receive an epidural later in the surgery to be used only for post operative pain.
- Status (registry)
- Completed
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 133 (actual)
- First submitted
- 8 Feb 2018
- Start date
- 30 Jan 2018
- Primary completion date
- 10 Jul 2024
- Lead sponsor
- Memorial Sloan Kettering Cancer Center
- Diseases
- Pancreatic cancer
- NCT number
- NCT03434678
What you commit to
- Study type: Interventional · Phase 3
- Participants enrolled: 133
- From 30 Jan 2018 to the primary completion date, 10 Jul 2024
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Use of a sustained release opioid medication such as long-acting morphine, fentanyl patches, methadone, and buprenorphine within the last 3 months
Other illness
- History of documented anaphylaxis or contraindication to any of the study medications
- Significant cognitive impairment or documented psychologic impairment
- Post randomization exclusion will occur if the patient is found to have unresectable disease at laparotomy and therefore will not have the potential for the same postoperative complications.
Other
- Pregnancy
- Contraindication to epidural per Pain Service guidelines
Who the study is looking for
- Adult patients ≥ 18 years of age who can provide informed consent
- Scheduled for pancreaticoduodenectomy
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Memorial Sloan Kettering Basking Ridge (Consent Only) Coordinator of this site? Confirm its status | Basking Ridge | United States | Unknown status |
| Memorial Sloan Kettering Commack (Consent only) Coordinator of this site? Confirm its status | Commack | United States | Unknown status |
| Memorial Sloan-Kettering Cancer Center Coordinator of this site? Confirm its status | New York | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.