NCT03436992Completed
Estrogen and Diabetes
Estrogen-Mediated Impairments of Vascular Health in Diabetes
Source: ClinicalTrials.gov · Last updated 17 Feb 2025
Brief summary (registry, in English)
Diabetes has recently been referred to as "the epidemic of the 21st century". The reason why women with type 1 diabetes have a 2-3 fold greater risk of cardiovascular disease (CVD) compared to men with type 1 diabetes is unknown.The purpose of this study is to investigate whether or not estrogen contributes to vascular dysfunction in premenopausal women with diabetes.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 143 (actual)
- First submitted
- 13 Feb 2018
- Start date
- 17 Apr 2018
- Primary completion date
- 1 Sept 2023
- Lead sponsor
- Augusta University
- Diseases
- Type 1 diabetes
- NCT number
- NCT03436992
What you commit to
- Study type: Interventional
- Participants enrolled: 143
- From 17 Apr 2018 to the primary completion date, 1 Sept 2023
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Direct vasoactive medications (i.e. nitrates)
Other illness
- Clinical diagnosis of hepatic, cardiovascular, or renal disease
- Uncontrolled Hypertension (\>140/90 mmHg on therapy)
- Plycystic ovarian syndrome (defined by NIH guidelines-hyperandrogenic anovulation)
Lab values
- Uncontrolled Diabetes (HbA1c\>9%)
Other
- Diabetic complications (i.e. macrovascular, microvascular, or autonomic)
- Proteinuria
- Hormonal use of birth control (past 3 months)
- Pregnancy
- Oligomenorrhea
- Anti-estrogens (i.e. SERMs)
- Undetectable Anti-Mullerian Hormone (AMH) following screening
Who the study is looking for
- Both men and premenopausal
- Normal menstrual cycle interval of 25-35 days for at least 3 previous cycles
- All races
- Clinical diagnosis of insulin-dependent type 1 diabetes (patients only)
Age in the registry: 18 years to 40 years · Sex: All · Accepts healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Augusta University Coordinator of this site? Confirm its status | Augusta | United States | Unknown status |
| Georgia prevention institute Coordinator of this site? Confirm its status | Augusta | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.