NCT03442101Active, not recruiting
Trajectories of Treatment Response as Window Into the Heterogeneity of Psychosis: a Longitudinal Multimodal Imaging Study
Trajectories of Treatment Response as Window Into the Heterogeneity of Psychosis: a Longitudinal Multimodal Imaging Study in Medication-naïve First Episode Psychosis Patients
Source: ClinicalTrials.gov · Last updated 12 Jan 2026
Brief summary (registry, in English)
Psychosis is a heterogeneous disorder and present treatment only works for a limited number of patients. In order to identify new therapeutic targets, this study will longitudinally characterize the underlying pathologies in those with poor treatment response using complimentary brain imaging modalities.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 156 (actual)
- First submitted
- 9 Feb 2018
- Start date
- 1 Apr 2018
- Primary completion date
- 30 Dec 2026
- Lead sponsor
- University of Alabama at Birmingham
- Diseases
- Schizophrenia
- NCT number
- NCT03442101
What you commit to
- Study type: Observational
- Participants enrolled: 156
- From 1 Apr 2018 to the primary completion date, 30 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Treatment with drugs known to affect brain glutamate levels
Other illness
- Poorly controlled acute or chronic medical and neurological conditions
- History of head trauma with loss of consciousness for \>2 minutes
Other
- Inability to sign informed consent assessed by the Evaluation to sign - - Consent form
- Clinically significant depression, hypomania, or mania
- Active substance abuse or dependence (except for nicotine)
- Suspected substance-induced psychosis
- Pregnant females
Who the study is looking for
- A diagnosis of first episode psychosis
- Never been treated with an antipsychotic medication
- Between the age of 17 and 35
Age in the registry: 17 years to 35 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Sparks Center Coordinator of this site? Confirm its status | Birmingham | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.