NCT03447938Active, not recruiting
The Minimally Invasive Coronary Surgery Compared to STernotomy Coronary Artery Bypass Grafting Trial
The Minimally Invasive Coronary Surgery Compared to STernotomy Coronary Artery Bypass Grafting Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 12 May 2026
Brief summary (registry, in English)
MICS CABG (Minimally invasive coronary surgery), where coronary artery bypass grafting (CABG) is completed through a small incision over the left chest, has evolved to become a safe and less invasive alternative to conventional sternotomy CABG. Several observational studies have suggested significantly shorter time to return to physical activity for MICS CABG patients compared to sternotomy CABG patients. A randomized study is warranted to validate these findings, provide higher level of evidence, and potentially lead to changes in practice. The MIST Trial is a multi-centre, prospective, open label, randomized control trial comparing quality of life and recovery in the early post-operative period, between patients undergoing MICS CABG versus patients undergoing sternotomy CABG. Patients referred for isolated CABG for multi-vessel coronary artery disease and deemed technically suitable for sternotomy CABG as well as for MICS CABG are considered for enrollment into the trial. Quality of life questionnaires (The SF-36, Seattle Angina Questionnaire and EQ-5D-5L) will be used to assess the quality of life and recovery in patients undergoing sternotomy CABG or MICS CABG at 1 month, 3 months, 6 months and 12 months follow up.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 176 (estimated)
- First submitted
- 6 Feb 2018
- Start date
- 1 Sept 2018
- Primary completion date
- 31 Jan 2025
- Lead sponsor
- Ottawa Heart Institute Research Corporation
- Diseases
- Coronary artery disease
- NCT number
- NCT03447938
What you commit to
- Study type: Interventional
- Planned participants: 176
- From 1 Sept 2018 to the primary completion date, 31 Jan 2025
- 13 sites in 9 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- concomitant cardiac procedure with CABG (e.g. valve repair or replacement)
- Previous cardiac surgery, mediastinal irradiation, or significant trauma to the chest
- Concomitant life-threatening disease likely to limit life expectancy to \<2 years
Other illness
- Contra-indications for MICS CABG, including: severe pectus excavatum; severe pulmonary disease; hemodynamically significant left subclavian stenosis; morbid obesity; severe left ventricular (LV) dysfunction; no adequate PDA or marginal branch target; absence of femoral pulse bilaterally.
Age
- \<18 years of age
Other
- Contraindications for conventional CABG via sternotomy
- Emergency CABG with hemodynamic compromise
- Inability to provide informed consent.
Who the study is looking for
- 18 years of age or older
- Angiographically-confirmed multi-vessel coronary artery disease lesions with \>=70% in at least 2 major epicardial vessels in 2 or more coronary artery territories (left anterior descending (LAD), circumflex (CX) and right coronary artery (RCA)) OR lesions \>=50% in the left main (LM)
- Patients who, in the opinion of the investigator, are amenable for coronary surgery through either median sternotomy or minimally-invasive approach.
- Patients who are willing and able to comply with all follow-up study visits.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (13)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Universitaire Ziekenhuizen Leuven Coordinator of this site? Confirm its status | Leuven | Belgium | Unknown status |
| Division of Cardiac Surgery, University of Ottawa Heart Institute Coordinator of this site? Confirm its status | Ottawa | Canada | Unknown status |
| University Health Network Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| Jilin Heart Hospital Coordinator of this site? Confirm its status | Jilin City | China | Unknown status |
| Leipzig Heart Institute GmbH Coordinator of this site? Confirm its status | Leipzig | Germany | Unknown status |
| Robert-Bosch-Hospital Coordinator of this site? Confirm its status | Stuttgart | Germany | Unknown status |
| Apollo Hospital, Bangalore Coordinator of this site? Confirm its status | Bangalore | India | Unknown status |
| Manipal Hospitals Coordinator of this site? Confirm its status | New Delhi | India | Unknown status |
| Tokyo Bay Urayasu Ichikawa Medical Center Coordinator of this site? Confirm its status | Urayasu | Japan | Unknown status |
| National University Hospital (NUH) - Singapore Coordinator of this site? Confirm its status | Singapore | Singapore | Unknown status |
| Far Eastern Memorial Hospital Coordinator of this site? Confirm its status | Taipei | Taiwan | Unknown status |
| Gundersen Lutheran Medical Center Coordinator of this site? Confirm its status | La Crosse | United States | Unknown status |
| University of Pittsburgh Medical Center Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.