Sign in

NCT03453268Completed

Impact of Reducing Antihypertensive Treatment on Mortality in Frail Subjects With Low Systolic Blood Pressure (SBP).

Impact of Reducing Antihypertensive Treatment on Mortality in Frail Subjects With Low Systolic Blood Pressure (SBP). Multicenter, Randomized Controlled Study of Subjects Aged 80 and Over, Living in Nursing Homes and Other IMS.

Source: ClinicalTrials.gov · Last updated 20 Jul 2025

Brief summary (registry, in English)

The investigators hypothesize that a gradual reduction in antihypertensive treatment in medical-social institutions patients with low systolic blood pressure (SBP) can improve survival through a controlled increase in SBP and a decrease in secondary morbidity due to 'overmedication'. Accordingly, the investigators propose a randomized, case/control trial in NH patients ≥ 80 years with a SBP\<130 mmHg with \>1 anti-Htn drugs. This trial will consist of two parallel arms: the intervention arm will entail antihypertensive drug step-down, while the control arm will comprise the standard anti-hypertensive treatment.

Status (registry)
Completed
Study type
Interventional
Enrollment
1048 (actual)
First submitted
31 Jan 2018
Start date
2 Oct 2018
Primary completion date
15 Aug 2024
Lead sponsor
Assistance Publique - Hôpitaux de Paris
NCT number
NCT03453268

What you commit to

  • Study type: Interventional
  • Participants enrolled: 1048
  • From 2 Oct 2018 to the primary completion date, 15 Aug 2024
  • 124 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Lab values

  • Patients in whom no antihypertensive molecule can be reduced for specific reasons (heart failure with ejection fraction \<40%, fluid retention due to heart failure, coronary artery disease and diabetic nephropathy).

Other

  • Patients with an estimated life expectancy of \<3 months
  • Patients who have already been included in this study or in another study at the same time

Who the study is looking for

  • Male and female patients aged 80 and over
  • Patients living in nursing homes
  • Patients with a SBP \< 130 mmHg measured in Medical-Social Institutions using the connected blood pressure monitor supplied for the study (average of the last 2 out of 3 measurements after 10 min rest)
  • Hypertensive patients whose treatment contains at least 2 antihypertensive molecules and whose treatment has been stabilised for at least :
    • 3 weeks in the case of the introduction or discontinuation of an anti-HBP drug
    • 2 weeks in the case of a change in the dosage of one of the anti-HBP drugs.
  • Patients affiliated to a social security scheme
  • Patients who have signed the informed consent form (failing which, the legal representative)
  • Patients with dementia or with a severe reduction in physical function (impaired vision, asthenia, advanced osteoarthritis, severe tremors, etc.) and/or cognitive function may be included in this study with the agreement of their carers or family/relatives.

Age in the registry: 80 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (124)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
CHU Angoulême (Expert center)
Coordinator of this site? Confirm its status
AngoulêmeFranceUnknown status
Font Douce (Nursing Home)
Coordinator of this site? Confirm its status
AngoulêmeFranceUnknown status
Kerleano (Nursing Home)
Coordinator of this site? Confirm its status
AurayFranceUnknown status
Keriolet (Nursing Home)
Coordinator of this site? Confirm its status
AurayFranceUnknown status
Le Parc de la Plesse (Nursing Home)
Coordinator of this site? Confirm its status
AvrilléFranceUnknown status
Sentiers d'Automne (Nursing Home)
Coordinator of this site? Confirm its status
Bains-les-BainsFranceUnknown status
Parisot (Nursing Home)
Coordinator of this site? Confirm its status
Bainville-sur-MadonFranceUnknown status
EHPAD Fontarce (Nursing Home)
Coordinator of this site? Confirm its status
Bar-sur-SeineFranceUnknown status
EHPAD du CH (Nursing Home)
Coordinator of this site? Confirm its status
Bar-sur-SeineFranceUnknown status
USLD du CH (Nursing Home)
Coordinator of this site? Confirm its status
Bar-sur-SeineFranceUnknown status
Saint Charles (Nursing Home)
Coordinator of this site? Confirm its status
BayonFranceUnknown status
Argia (Nursing Home)
Coordinator of this site? Confirm its status
BayonneFranceUnknown status
Goxoki (Nursing Home)
Coordinator of this site? Confirm its status
BayonneFranceUnknown status
EHPAD du Prisse (Nursing home)
Coordinator of this site? Confirm its status
BayonneFranceUnknown status
EHPAD CH de Valence (Nursing home)
Coordinator of this site? Confirm its status
BeauvallonFranceUnknown status
USLD Espace Perréal (Nursing Home)
Coordinator of this site? Confirm its status
BéziersFranceUnknown status
Espace Perréal (Nursing Home)
Coordinator of this site? Confirm its status
BéziersFranceUnknown status
EHPAD Simone de Beauvoir (Nursing Home)
Coordinator of this site? Confirm its status
BéziersFranceUnknown status
CHU Bordeaux (Expert center)
Coordinator of this site? Confirm its status
BordeauxFranceUnknown status
La Croix Du Gue (Nursing Home)
Coordinator of this site? Confirm its status
BouguenaisFranceUnknown status
Poincaré (Nursing Home)
Coordinator of this site? Confirm its status
Bouxières-aux-DamesFranceUnknown status
Les Rives d'Ode (Nursing Home)
Coordinator of this site? Confirm its status
CarcassonneFranceUnknown status
Les jardin de Sophia (Nursing Home)
Coordinator of this site? Confirm its status
Castelnau-le-LezFranceUnknown status
EHPAD de Monges (Nursing Home)
Coordinator of this site? Confirm its status
CastresFranceUnknown status
La Villégiale Saint Jacques (Nursing Home)
Coordinator of this site? Confirm its status
CastresFranceUnknown status
Saint Martin (Nursing Home)
Coordinator of this site? Confirm its status
CharmesFranceUnknown status
Saint Jean (Nursing Home)
Coordinator of this site? Confirm its status
Charmois-l'OrgueilleuxFranceUnknown status
EHPAD CH Cotentin Pasteur (Nursing Home)
Coordinator of this site? Confirm its status
CherbourgFranceUnknown status
Centre pour Personnes Agées (Nursing Home)
Coordinator of this site? Confirm its status
ColmarFranceUnknown status
Diaconnat (Nursing home)
Coordinator of this site? Confirm its status
ColmarFranceUnknown status
Chantereine-Orpea (Nursing Home)
Coordinator of this site? Confirm its status
CoubronFranceUnknown status
Le Hameau de Saubagnacq (Nursing Home)
Coordinator of this site? Confirm its status
DaxFranceUnknown status
Les Bégonias (Nursing Home)
Coordinator of this site? Confirm its status
DijonFranceUnknown status
Les marguerites (Nursing Home)
Coordinator of this site? Confirm its status
DijonFranceUnknown status
Port du Canal (Nursing Home)
Coordinator of this site? Confirm its status
DijonFranceUnknown status
EHPAD CHU Dijon Bourgogne (Nursing Home)
Coordinator of this site? Confirm its status
DijonFranceUnknown status
CHU Dijon (Expert center)
Coordinator of this site? Confirm its status
DijonFranceUnknown status
EHPAD Simone Veil (Nursing Home)
Coordinator of this site? Confirm its status
EaubonneFranceUnknown status
Bas-Château (Nursing Home)
Coordinator of this site? Confirm its status
Essey-lès-NancyFranceUnknown status
Belfontaine (Nursing Home)
Coordinator of this site? Confirm its status
Fontaine-lès-DijonFranceUnknown status
Accueil Vologne (Nursing Home)
Coordinator of this site? Confirm its status
Granges-sur-VologneFranceUnknown status
Vallée Don (Nursing Home)
Coordinator of this site? Confirm its status
Guémené-PenfaoFranceUnknown status
EHPAD Orpéa (Nursing home)
Coordinator of this site? Confirm its status
La TalaudièreFranceUnknown status
Baudinet De Courcelles (Nursing home)
Coordinator of this site? Confirm its status
Lay-Saint-ChristopheFranceUnknown status
CHU Lille (Expert center)
Coordinator of this site? Confirm its status
LilleFranceUnknown status
Les Bateliers (Nursing Home)
Coordinator of this site? Confirm its status
LilleFranceUnknown status
Saint Antoine de Padoue (Nursing Home)
Coordinator of this site? Confirm its status
LilleFranceUnknown status
EHPAD de Lormont (Nursing Home)
Coordinator of this site? Confirm its status
LormontFranceUnknown status
Sainte Thérèse (Nursing Home)
Coordinator of this site? Confirm its status
LudresFranceUnknown status
Saint Charles (Nursing Home)
Coordinator of this site? Confirm its status
LunévilleFranceUnknown status
EHPAD Constant (Nursing Home)
Coordinator of this site? Confirm its status
LyonFranceUnknown status
CHU Lyon (Expert center)
Coordinator of this site? Confirm its status
LyonFranceUnknown status
La Renaissance-Orpea (Nursing Home)
Coordinator of this site? Confirm its status
MarseilleFranceUnknown status
Bon repos (Nursing Home)
Coordinator of this site? Confirm its status
MaxévilleFranceUnknown status
Saint Sauveur (Nursing Home)
Coordinator of this site? Confirm its status
MaxévilleFranceUnknown status
Félix Marechal (Nursing Home)
Coordinator of this site? Confirm its status
MetzFranceUnknown status
USLD Nouvielle (Nursing Home)
Coordinator of this site? Confirm its status
Mont-de-MarsanFranceUnknown status
Jeanne Callarec (Nursing Home)
Coordinator of this site? Confirm its status
MontmorencyFranceUnknown status
Coteaux de Montmorency (Nursing Home)
Coordinator of this site? Confirm its status
MontmorencyFranceUnknown status
CHU Montpellier (Expert center)
Coordinator of this site? Confirm its status
MontpellierFranceUnknown status
Antonin Balmès (Nursing Home)
Coordinator of this site? Confirm its status
MontpellierFranceUnknown status
CSPA Bellevue (Nursing Home)
Coordinator of this site? Confirm its status
MontpellierFranceUnknown status
EHPAD du CH (Nursing Home)
Coordinator of this site? Confirm its status
MuretFranceUnknown status
Notre Maison (Nursing home)
Coordinator of this site? Confirm its status
NancyFranceUnknown status
Gériatrie - CHRU de Nancy (Expert center)
Coordinator of this site? Confirm its status
NancyFranceUnknown status
Les Cygnes (Nursing Home)
Coordinator of this site? Confirm its status
NancyFranceUnknown status
Saint Charles EHPAD (Nursing Home)
Coordinator of this site? Confirm its status
NancyFranceUnknown status
Saint Joseph (Nursing Home)
Coordinator of this site? Confirm its status
NancyFranceUnknown status
Saint Stanislas (Nursing Home)
Coordinator of this site? Confirm its status
NancyFranceUnknown status
Saint Charles USLD (Nursing Home)
Coordinator of this site? Confirm its status
NancyFranceUnknown status
La Chézalière LNA Santé (Nursing Home)
Coordinator of this site? Confirm its status
NantesFranceUnknown status
CHU Nantes (Expert center)
Coordinator of this site? Confirm its status
NantesFranceUnknown status
Beauséjour (Nursing Home)
Coordinator of this site? Confirm its status
NantesFranceUnknown status
CHU Nice (Expert center)
Coordinator of this site? Confirm its status
NiceFranceUnknown status
EHPAD Cimiez du CHU (Nursing Home)
Coordinator of this site? Confirm its status
NiceFranceUnknown status
EHPAD GHAM (Nursing Home)
Coordinator of this site? Confirm its status
Nogent-sur-SeineFranceUnknown status
Bethel (Nursing Home)
Coordinator of this site? Confirm its status
OberhausbergenFranceUnknown status
Les Jardins d'Olonne (Nursing Home)
Coordinator of this site? Confirm its status
Olonne-sur-MerFranceUnknown status
Résidence Mer et Estuaire (Nursing Home)
Coordinator of this site? Confirm its status
PaimboeufFranceUnknown status
EHPAD Broca (Nursing Home)
Coordinator of this site? Confirm its status
ParisFranceUnknown status
La Collégiale (Nursing Home)
Coordinator of this site? Confirm its status
ParisFranceUnknown status
Saint Jacques Orpea (Nursing Home)
Coordinator of this site? Confirm its status
ParisFranceUnknown status
APHP (Expert center)
Coordinator of this site? Confirm its status
ParisFranceUnknown status
Trocadéro-Orpéa (Nursing Home)
Coordinator of this site? Confirm its status
ParisFranceUnknown status
CHU Périgueux (Expert center)
Coordinator of this site? Confirm its status
PérigueuxFranceUnknown status
EHPAD Parrot (Nursing Home)
Coordinator of this site? Confirm its status
PérigueuxFranceUnknown status
USLD Pessac (Nursing Home)
Coordinator of this site? Confirm its status
PessacFranceUnknown status
Avant-Garde (Nursing Home)
Coordinator of this site? Confirm its status
PompeyFranceUnknown status
La Salle (Nursing Home)
Coordinator of this site? Confirm its status
PompeyFranceUnknown status
Nazareth (Nursing Home)
Coordinator of this site? Confirm its status
Pont-Sainte-MarieFranceUnknown status
Saint Jean (Nursing Home)
Coordinator of this site? Confirm its status
PortieuxFranceUnknown status
Jacques Mellez (Nursing Home)
Coordinator of this site? Confirm its status
Raon-l'ÉtapeFranceUnknown status
Résidence Roux CHU Reims (Nursing Home)
Coordinator of this site? Confirm its status
ReimsFranceUnknown status
CHU Reims (Expert center)
Coordinator of this site? Confirm its status
ReimsFranceUnknown status
AHPAD AB2 Wilson (Nursing Home)
Coordinator of this site? Confirm its status
ReimsFranceUnknown status
Le Clos des platanes (Nursing Home)
Coordinator of this site? Confirm its status
Romilly-sur-SeineFranceUnknown status
Julien Monnard (Nursing Home)
Coordinator of this site? Confirm its status
Romilly-sur-SeineFranceUnknown status
Mer et Pins Fleur d'Ajonc (Nursing Home)
Coordinator of this site? Confirm its status
Saint-Brevin-les-PinsFranceUnknown status
EHPAD Mer Et Pins (Nursing Home)
Coordinator of this site? Confirm its status
Saint-Brevin-les-PinsFranceUnknown status
Mer et Pins les Sylphes (Nursing Home)
Coordinator of this site? Confirm its status
Saint-Brevin-les-PinsFranceUnknown status
Saint Deodat (Nursing Home)
Coordinator of this site? Confirm its status
Saint-DiéFranceUnknown status
Fauriel (Nursing Home)
Coordinator of this site? Confirm its status
Saint-EtienneFranceUnknown status
EHPAD de Saint Genest (Nursing Home)
Coordinator of this site? Confirm its status
Saint-GenestFranceUnknown status
Udazkena (Nursing Home)
Coordinator of this site? Confirm its status
Saint-Jean-de-LuzFranceUnknown status
Hotel Club (Nursing Home)
Coordinator of this site? Confirm its status
Saint-MaxFranceUnknown status
EHPAD De Senones (Nursing Home)
Coordinator of this site? Confirm its status
SenonesFranceUnknown status
EHPAD Sézanne (Nursing Home)
Coordinator of this site? Confirm its status
SézanneFranceUnknown status
EHPAD CHRU Robertsau (Nursing Home)
Coordinator of this site? Confirm its status
StrasbourgFranceUnknown status
EHPAD Bois Fleuri (Nursing Home)
Coordinator of this site? Confirm its status
StrasbourgFranceUnknown status
CHU Strasbourg (Expert center)
Coordinator of this site? Confirm its status
StrasbourgFranceUnknown status
La Christinière ACPPA (Nursing Home)
Coordinator of this site? Confirm its status
TaluyersFranceUnknown status
Sainte Sophie (Nursing Home)
Coordinator of this site? Confirm its status
Thiaucourt-RegniévilleFranceUnknown status
CHU Toulouse (Expert center)
Coordinator of this site? Confirm its status
ToulouseFranceUnknown status
Jolimont Marengo Orpea (Nursing Home)
Coordinator of this site? Confirm its status
ToulouseFranceUnknown status
Clinique les Minimes (Nursing Home)
Coordinator of this site? Confirm its status
ToulouseFranceUnknown status
Klarene-Orpea (Nursing Home)
Coordinator of this site? Confirm its status
Tournan-en-BrieFranceUnknown status
CHP Cotentin Simone Veil (Nursing Home)
Coordinator of this site? Confirm its status
ValognesFranceUnknown status
USLD Maison du Lac (Nursing Home)
Coordinator of this site? Confirm its status
VannesFranceUnknown status
EHPAD Maison du Lac (Nursing Home)
Coordinator of this site? Confirm its status
VannesFranceUnknown status
Sainte Catherine (Nursing Home)
Coordinator of this site? Confirm its status
VerdunFranceUnknown status
Montagne de Reims (Nursing home)
Coordinator of this site? Confirm its status
Villers-AllerandFranceUnknown status
Villa Saint-Pierre (Nursing Home)
Coordinator of this site? Confirm its status
Villers-lès-NancyFranceUnknown status
Saint Joseph (Nursing Home)
Coordinator of this site? Confirm its status
Ville-sur-IllonFranceUnknown status
Les Buissons (Nursing Home)
Coordinator of this site? Confirm its status
XertignyFranceUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.