NCT03464344Completed
Cortical Superficial Siderosis and Risk of Recurrent Intracerebral Hemorrhage in Cerebral Amyloid Angiopathy.
COrtical Superficial Siderosis and REcurrent Lobar Intracerebral Hemorrhage in Cerebral Amyloid Angiopathy.
Source: ClinicalTrials.gov · Last updated 31 Dec 2025
Brief summary (registry, in English)
Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage (ICH) in the elderly with high risk of recurrence. The investigators aim to determine the relationship between cortical superficial siderosis (cSS), a MRI hemorrhagic marker of CAA and the risk of symptomatic ICH recurrence in a multicentric prospective cohort of patients with acute lobar ICH related to CAA. The investigators hypothesize that patients with cSS have an increased risk of recurrent symptomatic ICH relative to those without cSS.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 170 (actual)
- First submitted
- 7 Mar 2018
- Start date
- 12 Oct 2018
- Primary completion date
- 11 Feb 2025
- Lead sponsor
- University Hospital, Toulouse
- NCT number
- NCT03464344
What you commit to
- Study type: Interventional
- Participants enrolled: 170
- From 12 Oct 2018 to the primary completion date, 11 Feb 2025
- 4 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Secondary brain hemorrhage : vascular malformation (arteriovenous malformation, aneurysm, cavernous); cerebral veinous thrombosis; brain tumor; coagulopathy; vasculitis; hemorrhagic infarction,
Other
- Infratentorial siderosis
- Contraindications to MRI
- Neurosurgical intervention before inclusion,
- Progressive neoplasm
- Patient without affiliation to the french social security
- Patient under guardianship
Who the study is looking for
- Lobar ICH within 30 days after onset
- Available brain MRI sequences of adequate quality including fluid-attenuated inversion recovery (FLAIR) and T2\*-weighted gradient-recalled echo (T2\*-GRE) sequences.
- Modified Boston criteria for probable or possible CAA
- Age ≥ 55 years
- Written consent
Age in the registry: 55 years to - · Sex: All · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Pellegrin Hospital Coordinator of this site? Confirm its status | Bordeaux | France | Unknown status |
| Gui de Chauliac Hospital Coordinator of this site? Confirm its status | Montpellier | France | Unknown status |
| Lariboisière Hospital Coordinator of this site? Confirm its status | Paris | France | Unknown status |
| CHU Purpan. Hôpital Pierre-Paul Riquet Coordinator of this site? Confirm its status | Toulouse | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.