NCT03466346Completed
SMART-DAPPER: Leveraging the Depression And Primary-care Partnership for Effectiveness-implementation Research Project
A Sequential, Multiple Assignment Randomized Trial (SMART) for Non-specialist Treatment of Common Mental Disorders in Kenya: Leveraging the Depression And Primary-care Partnership for Effectiveness-implementation Research (DAPPER) Project
Source: ClinicalTrials.gov · Last updated 2 Dec 2025
Brief summary (registry, in English)
Despite carrying the vast majority of the global mental disorder burden, 75% of adults with mental disorders in Low and Middle Income Countries have no access to services. This study will test strategies for integrating first and second line evidence-based depression and trauma-related disorder treatments with primary care services at a large public sector hospital and conduct robust cost and cost-benefit analyses of each treatment to produce a "menu" of cost-benefit options for personalized, integrated mental health care with corresponding effectiveness and implementation values.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 2162 (actual)
- First submitted
- 2 Mar 2018
- Start date
- 31 Aug 2020
- Primary completion date
- 6 May 2024
- Lead sponsor
- University of California, San Francisco
- Diseases
- Depression
- NCT number
- NCT03466346
What you commit to
- Study type: Interventional
- Participants enrolled: 2162
- From 31 Aug 2020 to the primary completion date, 6 May 2024
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- drug/alcohol use disorders requiring substance use treatment (AUDIT score of 8 or higher, DAST score of 3 or higher)
- history of mania or requiring treatment for hypomania
Other
- Cognitive dysfunction compromising ability to participate in IPT or accurately take fluoxetine (lack of orientation to person, place, time and situation)
- acute suicidality requiring higher level of care
- Outside mental health treatment during the study treatment phases (any mental health treatment is allowed during follow-up phases and is recorded by study team).
Who the study is looking for
- Kisumu County Hospital (KCH) adult primary care outpatient clinic attendees who screen positive for depression and/or PTSD
- Ability to attend weekly IPT sessions/fluoxetine monitoring; (3) 18 years or older
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Lumumba Health Center Coordinator of this site? Confirm its status | Kisumu | Kenya | Unknown status |
| Jaramogi Oginga Odinga Teaching and Referral Hospital (JOOTRH) Coordinator of this site? Confirm its status | Kisumu | Kenya | Unknown status |
| Kisumu County Hospital Coordinator of this site? Confirm its status | Kisumu | Kenya | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.