NCT03470922Active, not recruitingPhase 2/3
A Study of Relatlimab Plus Nivolumab Versus Nivolumab Alone in Participants With Advanced Melanoma
A Randomized, Double-Blind Phase 2/3 Study of Relatlimab Combined With Nivolumab Versus Nivolumab in Participants With Previously Untreated Metastatic or Unresectable Melanoma
Source: ClinicalTrials.gov · Last updated 9 Sept 2025
Brief summary (registry, in English)
The purpose of this study is to determine whether relatlimab in combination with nivolumab is more effective than nivolumab monotherapy in treating unresectable melanoma or melanoma that has spread.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 2/3
- Study type
- Interventional
- Enrollment
- 714 (actual)
- First submitted
- 14 Mar 2018
- Start date
- 11 Apr 2018
- Primary completion date
- 25 Jan 2021
- Lead sponsor
- Bristol-Myers Squibb
- Diseases
- Melanoma, Childhood cancers
- NCT number
- NCT03470922
- EU CT number
- 2024-510913-13-00
- EudraCT number
- 2017-003583-12
What you commit to
- Study type: Interventional · Phase 2/3
- Participants enrolled: 714
- From 11 Apr 2018 to the primary completion date, 25 Jan 2021
- 113 sites in 25 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Participants must not have an active, known, or suspected autoimmune disease
- Other protocol defined inclusion/exclusion criteria could apply
Other
- Participants must not have active brain metastases or leptomeningeal metastases
- Participants must not have uveal melanoma
Who the study is looking for
- Participants must have histologically confirmed Stage III (unresectable) or Stage IV melanoma, per the AJCC staging system
- Participants must not have had prior systemic anticancer therapy for unresectable or metastatic melanoma
- Tumor tissue from an unresectable or metastatic site of disease must be provided for biomarker analyses
Criteria the registry did not label
- For more information regarding Bristol-Myers Squibb Clinical Trial participation, please visit www.BMSStudyConnect.com
Age in the registry: 12 years to - · Sex: All · Does not accept healthy volunteers
Sites (113)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Local Institution - 0004 Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| Local Institution - 0135 Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| Local Institution - 0005 Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| Local Institution - 0003 Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| Local Institution - 0002 Coordinator of this site? Confirm its status | Capital Federal | Argentina | Unknown status |
| Medical University of Graz Coordinator of this site? Confirm its status | Graz | Austria | Active, not recruiting |
| Gemeinnutzige Salzburger Landes kliniken Betriebsgesellschaft mbH Coordinator of this site? Confirm its status | Salzburg | Austria | Active, not recruiting |
| Medical University of Vienna Coordinator of this site? Confirm its status | Vienna | Austria | Active, not recruiting |
| Local Institution - 0133 Coordinator of this site? Confirm its status | Bedford Park | Australia | Unknown status |
| Local Institution - 0041 Coordinator of this site? Confirm its status | Greenslopes | Australia | Unknown status |
| Local Institution - 0044 Coordinator of this site? Confirm its status | Murdoch | Australia | Unknown status |
| Local Institution - 0042 Coordinator of this site? Confirm its status | North Sydney | Australia | Unknown status |
| Local Institution - 0045 Coordinator of this site? Confirm its status | Southport | Australia | Unknown status |
| Local Institution - 0043 Coordinator of this site? Confirm its status | Waratah | Australia | Unknown status |
| Universitair Ziekenhuis Gent Coordinator of this site? Confirm its status | Gent | Belgium | Active, not recruiting |
| Local Institution - 0058 Coordinator of this site? Confirm its status | Belo Horizonte | Brazil | Unknown status |
| Local Institution - 0061 Coordinator of this site? Confirm its status | Porto Alegre | Brazil | Unknown status |
| Local Institution - 0057 Coordinator of this site? Confirm its status | Porto Alegre | Brazil | Unknown status |
| Local Institution - 0059 Coordinator of this site? Confirm its status | Rio de Janiro | Brazil | Unknown status |
| Local Institution - 0073 Coordinator of this site? Confirm its status | Santa Cruz do Sul | Brazil | Unknown status |
| Local Institution - 0063 Coordinator of this site? Confirm its status | São Paulo | Brazil | Unknown status |
| Local Institution - 0060 Coordinator of this site? Confirm its status | São Paulo | Brazil | Unknown status |
| Local Institution - 0062 Coordinator of this site? Confirm its status | São Paulo | Brazil | Unknown status |
| Local Institution - 0124 Coordinator of this site? Confirm its status | Halifax | Canada | Unknown status |
| Local Institution - 0075 Coordinator of this site? Confirm its status | Montreal | Canada | Unknown status |
| Local Institution - 0123 Coordinator of this site? Confirm its status | Montreal | Canada | Unknown status |
| Local Institution - 0068 Coordinator of this site? Confirm its status | Ottawa | Canada | Unknown status |
| Local Institution - 0128 Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| Local Institution - 0001 Coordinator of this site? Confirm its status | Santiago | Chile | Unknown status |
| Local Institution - 0095 Coordinator of this site? Confirm its status | Bogotá | Colombia | Unknown status |
| Local Institution - 0096 Coordinator of this site? Confirm its status | Medellín | Colombia | Unknown status |
| Elbe Kliniken Stade-Buxtehude Elbe Klinikum Buxtehude gGmbH Coordinator of this site? Confirm its status | Buxtehude | Germany | Active, not recruiting |
| University Hospital Cologne AöR Coordinator of this site? Confirm its status | Cologne | Germany | Active, not recruiting |
| HELIOS Klinikum Erfurt GmbH Coordinator of this site? Confirm its status | Erfurt | Germany | Active, not recruiting |
| Medizinische Hochschule Hannover Coordinator of this site? Confirm its status | Hanover | Germany | Active, not recruiting |
| Universitaetsklinikum Heidelberg AöR Coordinator of this site? Confirm its status | Heidelberg | Germany | Active, not recruiting |
| Universitaetsklinikum Schleswig-Holstein AöR Coordinator of this site? Confirm its status | Luebeck | Germany | Active, not recruiting |
| Universitat Heidelberg Coordinator of this site? Confirm its status | Mannheim | Germany | Active, not recruiting |
| Klinikum rechts der Isar der TU Muenchen AöR Coordinator of this site? Confirm its status | Munich | Germany | Active, not recruiting |
| Harzklinikum Dorothea Christiane Erxleben GmbH Coordinator of this site? Confirm its status | Quedlinburg | Germany | Active, not recruiting |
| Universitaetsklinikum Tuebingen AöR Coordinator of this site? Confirm its status | Tuebingen | Germany | Active, not recruiting |
| Universitaetsklinikum Wuerzburg AöR Coordinator of this site? Confirm its status | Wuerzburg | Germany | Active, not recruiting |
| Region Hovedstaden Coordinator of this site? Confirm its status | Herlev | Denmark | Active, not recruiting |
| Hospital Clinic de Barcelona Coordinator of this site? Confirm its status | Barcelona | Spain | Active, not recruiting |
| Vall D'hebron Institut De Recerca Coordinator of this site? Confirm its status | Barcelona | Spain | Active, not recruiting |
| Fundacion Onkologikoa Fundazioa Coordinator of this site? Confirm its status | Donostia | Spain | Active, not recruiting |
| Hospital Universitario Virgen De La Macarena Coordinator of this site? Confirm its status | Sevilla | Spain | Active, not recruiting |
| HUS-Yhtymae Coordinator of this site? Confirm its status | Helsinki | Finland | Active, not recruiting |
| Oulu University Hospital Coordinator of this site? Confirm its status | Oulu | Finland | Active, not recruiting |
| Tampere University Hospital Coordinator of this site? Confirm its status | Tampere | Finland | Active, not recruiting |
| Turku University Hospital Coordinator of this site? Confirm its status | Turku | Finland | Active, not recruiting |
| Centre Hospitalier Universitaire Amiens - Picardie Coordinator of this site? Confirm its status | Amiens | France | Active, not recruiting |
| Centre hospitalier Universitaire de Bordeaux Coordinator of this site? Confirm its status | Bordeaux | France | Active, not recruiting |
| Centre Hospitalier Universitaire De Lille Coordinator of this site? Confirm its status | Lille Cedex | France | Active, not recruiting |
| Centre Hospitalier Regional De Marseille Coordinator of this site? Confirm its status | Marseille | France | Active, not recruiting |
| Hopital Saint Louis Coordinator of this site? Confirm its status | Paris | France | Active, not recruiting |
| Centre Hospitalier Lyon-Sud Coordinator of this site? Confirm its status | Pierre-Bénite | France | Active, not recruiting |
| Centre Hospitalier Universitaire de Poitiers Coordinator of this site? Confirm its status | Poitiers | France | Active, not recruiting |
| Centre De Lutte Contre Le Cancer Eugene Marquis Coordinator of this site? Confirm its status | Rennes Cedex | France | Active, not recruiting |
| Local Institution - 0052 Coordinator of this site? Confirm its status | Bristol | United Kingdom | Unknown status |
| Local Institution - 0054 Coordinator of this site? Confirm its status | Glasgow | United Kingdom | Unknown status |
| Local Institution - 0126 Coordinator of this site? Confirm its status | Inverness | United Kingdom | Unknown status |
| Local Institution - 0051 Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| Local Institution - 0056 Coordinator of this site? Confirm its status | Swansea | United Kingdom | Unknown status |
| Laiko General Hospital of Athens Coordinator of this site? Confirm its status | Athens | Greece | Active, not recruiting |
| Local Institution - 0086 Coordinator of this site? Confirm its status | Haifa | Israel | Unknown status |
| Local Institution - 0088 Coordinator of this site? Confirm its status | Jerusalem | Israel | Unknown status |
| Local Institution - 0087 Coordinator of this site? Confirm its status | Ramat Gan | Israel | Unknown status |
| Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII Coordinator of this site? Confirm its status | Bergamo | Italy | Active, not recruiting |
| Fondazione IRCCS - Istituto Nazionale dei Tumori Coordinator of this site? Confirm its status | Milan | Italy | Active, not recruiting |
| IRCCS Istituto Nazionale Tumori Fondazione Pascale Coordinator of this site? Confirm its status | Naples | Italy | Active, not recruiting |
| Istituto Oncologico Veneto Coordinator of this site? Confirm its status | Padova | Italy | Active, not recruiting |
| Azienda Ospedaliera Universitaria Senese Coordinator of this site? Confirm its status | Siena | Italy | Active, not recruiting |
| Local Institution - 0093 Coordinator of this site? Confirm its status | Cancún | Mexico | Unknown status |
| Local Institution - 0092 Coordinator of this site? Confirm its status | Mérida | Mexico | Unknown status |
| Local Institution - 0091 Coordinator of this site? Confirm its status | Monterrey | Mexico | Unknown status |
| Local Institution - 0129 Coordinator of this site? Confirm its status | Veracruz | Mexico | Unknown status |
| Local Institution - 0094 Coordinator of this site? Confirm its status | Zapopan | Mexico | Unknown status |
| Oslo University Hospital HF Coordinator of this site? Confirm its status | Oslo | Norway | Active, not recruiting |
| Local Institution - 0090 Coordinator of this site? Confirm its status | Dunedin | New Zealand | Unknown status |
| Local Institution - 0125 Coordinator of this site? Confirm its status | Hamilton | New Zealand | Unknown status |
| Local Institution - 0089 Coordinator of this site? Confirm its status | Tauranga | New Zealand | Unknown status |
| Uniwersytecki Szpital Kliniczny w Poznaniu Coordinator of this site? Confirm its status | Poznan | Poland | Active, not recruiting |
| Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy Coordinator of this site? Confirm its status | Warsaw | Poland | Active, not recruiting |
| Institute Of Oncology Prof. Dr. Ion Chiricuta Cluj-Napoca Coordinator of this site? Confirm its status | Cluj-Napoca | Romania | Active, not recruiting |
| Centrul De Oncologie SF Nectarie S.R.L. Coordinator of this site? Confirm its status | Craiova | Romania | Active, not recruiting |
| Local Institution - 0113 Coordinator of this site? Confirm its status | Krasnodar | Russia | Unknown status |
| Local Institution - 0127 Coordinator of this site? Confirm its status | Krasnoyarsk | Russia | Unknown status |
| Local Institution - 0112 Coordinator of this site? Confirm its status | Moscow | Russia | Unknown status |
| Sahlgrenska University Hospital-Vaestra Goetalandsregionen Coordinator of this site? Confirm its status | Goteborg | Sweden | Active, not recruiting |
| Region Skane Skanes Universitetssjukhus Coordinator of this site? Confirm its status | Lund | Sweden | Active, not recruiting |
| Local Institution - 0019 Coordinator of this site? Confirm its status | Allentown | United States | Unknown status |
| Local Institution - 0015 Coordinator of this site? Confirm its status | Ann Arbor | United States | Unknown status |
| Local Institution - 0038 Coordinator of this site? Confirm its status | Atlanta | United States | Unknown status |
| Local Institution - 0120 Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| Local Institution - 0077 Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| Local Institution - 0014 Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Local Institution - 0134 Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Local Institution - 0018 Coordinator of this site? Confirm its status | Charlotte | United States | Unknown status |
| Local Institution - 0016 Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| Local Institution - 0076 Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Local Institution - 0114 Coordinator of this site? Confirm its status | Fort Wayne | United States | Unknown status |
| Local Institution - 0008 Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| Local Institution - 0013 Coordinator of this site? Confirm its status | Jacksonville | United States | Unknown status |
| Local Institution - 0020 Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| Local Institution - 0009 Coordinator of this site? Confirm its status | Minneapolis | United States | Unknown status |
| Local Institution - 0117 Coordinator of this site? Confirm its status | Orlando | United States | Unknown status |
| Local Institution - 0011 Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
| Coastal Integrative Cancer Care Coordinator of this site? Confirm its status | San Luis Obispo | United States | Unknown status |
| Local Institution - 0116 Coordinator of this site? Confirm its status | Santa Barbara | United States | Unknown status |
| Local Institution - 0007 Coordinator of this site? Confirm its status | Tampa | United States | Unknown status |
| Local Institution - 0010 Coordinator of this site? Confirm its status | Tucson | United States | Unknown status |
| Local Institution - 0012 Coordinator of this site? Confirm its status | Washington D.C. | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.